2022
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regression
2021
Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark
Xiao J, Gao Y, Yu Y, Toft G, Zhang Y, Luo J, Xia Y, Chawarska K, Olsen J, Li J, Liew Z. Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark. International Journal Of Epidemiology 2021, 50: 485-495. PMID: 33411909, PMCID: PMC8128455, DOI: 10.1093/ije/dyaa246.Peer-Reviewed Original ResearchConceptsBirth characteristicsAutism spectrum disorder (ASD) riskCohort studyOdds ratioNationwide register-based cohort studySociodemographic factorsRegister-based cohort studyOffspring of mothersConfidence intervalsASD riskHealth-related factorsExposure risk factorsDisorder riskLogistic regression modelsOffspring of parentsPerinatal factorsPreterm birthFather-child pairsLow birthweightVery pretermEpidemiological evidenceRisk factorsHigh riskElevated riskPaternal factors
2020
Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasmaAssociation of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children
Gao Y, Yu Y, Xiao J, Luo J, Zhang Y, Tian Y, Zhang J, Olsen J, Li J, Liew Z. Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children. JAMA Network Open 2020, 3: e202868. PMID: 32293683, PMCID: PMC7160691, DOI: 10.1001/jamanetworkopen.2020.2868.Peer-Reviewed Original ResearchConceptsGrandparental ageAdvanced parental ageParental ageOdds ratioDanish national health registriesMaternal age 40 yearsMultigenerational cohortASD riskDanish Psychiatric Central RegisterAutism spectrum disorderNational health registriesAge 40 yearsAge 50 yearsPsychiatric Central RegisterRisk of ASDLogistic regression analysisPaternal grandmotherTime of birthCentral RegisterCohort studyHealth registriesMaternal ageSingleton childrenMAIN OUTCOMESpectrum disorder