Jianlei Gu
Associate Research Scientist in BiostatisticsCards
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Research
Publications
2026
Authors' Reply: Nephron-Segment Composition and Apparent Fatty Acid Oxidation Suppression in Pkd1KO+Glis3KO Kidneys
Wei Z, Gu J, Somlo S. Authors' Reply: Nephron-Segment Composition and Apparent Fatty Acid Oxidation Suppression in Pkd1KO+Glis3KO Kidneys. Journal Of The American Society Of Nephrology 2026 DOI: 10.1681/asn.0000001038.Peer-Reviewed Original Research
2025
PERADIGM: Phenotype embedding similarity-based rare disease gene mapping
Zheng W, Xie Y, Gu J, Li H, Somlo S, Besse W, Zhao H. PERADIGM: Phenotype embedding similarity-based rare disease gene mapping. PLOS Genetics 2025, 21: e1011976. PMID: 41411243, PMCID: PMC12714201, DOI: 10.1371/journal.pgen.1011976.Peer-Reviewed Original ResearchConceptsRare disease geneticsDisease gene discoveryAutosomal dominant polycystic kidney diseaseComprehensive phenotypic informationDisease geneticsGene discoveryGene mappingPhenotypic informationIndividual phenotypesElectronic health recordsBinary disease statusDisease-specific phenotypesDominant polycystic kidney diseaseGenesPhenotypePolycystic kidney diseaseUK Biobank datasetNeurofibromatosis type 1Precision medicineHealth recordsBiobank datasetICD-10Association methodStatistical powerRare diseaseGlis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease.
Wei Z, Gu J, Tian X, Zhang C, Zhao H, Somlo S. Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2025 PMID: 41563804, DOI: 10.1681/asn.0000000980.Peer-Reviewed Original ResearchPolycystin-1Autosomal dominant polycystic kidney diseaseRNA-seqAllelic seriesTranscription factorsPolycystin-2Polycystic kidney diseaseIn vivo genetic interactionChromatin accessibility assaysDominant polycystic kidney diseaseChromatin accessibility analysesPolycystin-1 expressionRibosome affinity purificationPolycystin signalingATAC-seqFatty acid metabolismGenetic interactionsCiliary localizationGene familyLive cell imagingEpithelial cell metabolismAffinity purificationGenetic relationshipsEarly effectorsProtein expression studiesPdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice
Zhang L, Xing Y, Wang P, Gu J, Peng J, Huang J, Pearson J, Hu Y, Zhao H, Wong F, Wen L. Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice. Frontiers In Endocrinology 2025, 16: 1630979. PMID: 41234234, PMCID: PMC12605365, DOI: 10.3389/fendo.2025.1630979.Peer-Reviewed Original ResearchConceptsB cell apoptosisB cell functionApoptosis of beta-cellsAminoacyl-tRNA synthetasesB cellsGlucose metabolismType 2 diabetesExpression of Gadd45bB cell-specificB cell survivalPI3K pathwayInsulin contentApoptotic pathwayInsulin biosynthesisHigh-fat diet conditionsDownstream effectorsSignaling pathwayIslet B-cell functionB-cell dysfunctionBeta-cellsATF5 expressionK pathwayB cell proliferationDevelopment of type 2 diabetesApoptosisTRLS-11 UNCOVERING ANTIGEN-SPECIFICITY OF INTRATUMORAL CD8+ T CELLS IN NON-SMALL CELL LUNG CANCER BRAIN METASTASES
Lu B, Yahsi B, Gu J, Coburn J, Kasbe M, Arnal-Estape A, Sohn K, Whitehead K, Mosharraf M, Nguyen D, Zhao H, Lucca L, Schalper K, Chiang V, Hafler D, Lee M. TRLS-11 UNCOVERING ANTIGEN-SPECIFICITY OF INTRATUMORAL CD8+ T CELLS IN NON-SMALL CELL LUNG CANCER BRAIN METASTASES. Neuro-Oncology Advances 2025, 7: ii36-ii36. PMCID: PMC12342607, DOI: 10.1093/noajnl/vdaf123.134.Peer-Reviewed Original ResearchNon-small cell lung cancerCD8+ T cellsIntratumoral T cellsPatient lung tumorsT cellsBrain metastasesAntigen-SpecificTumor reactivityClonal repertoireNon-small cell lung cancer brain metastasisIntratumoral CD8+ T cellsPublic antigensTumor-infiltrating T cellsCD8+ T cellsAntitumor T-cell functionDegree of clonal expansionT-cell receptor (TCR) sequencingT-cell therapyImmune-modulating therapiesTumor-associated antigensCell lung cancerT cell functionAntigenic reactivitySomatic single-nucleotide variantsResected tumorCorrection: Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes
Uhm C, Gu J, Ju W, Pizzella S, Oktay H, Peng J, Guariglia S, Liu Y, Zhao H, Wang Y, Menon R, Zhong N. Correction: Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes. Cell & Bioscience 2025, 15: 90. PMID: 40571915, PMCID: PMC12203711, DOI: 10.1186/s13578-025-01421-x.Peer-Reviewed Original ResearchTumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV
Desai S, Salahuddin S, Yusuf R, Ranjan K, Gu J, Osmani L, Lin Y, Mehta S, Talmon R, Kang I, Kluger Y, Zhao H, Schalper K, Emu B. Tumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV. Journal Of Clinical Investigation 2025, 135: e177310. PMID: 40459946, PMCID: PMC12259253, DOI: 10.1172/jci177310.Peer-Reviewed Original ResearchNon-small cell lung cancerTumor microenvironmentImmune cellsLung cancerCohort of non-small cell lung cancerExpression of PD-1Impairs anti-tumor responsesTumor-infiltrating CD8+Tumor-specific immune responsesCD4+ T cellsHIV-associated tumorsInfiltrating CD8+Expression of immunoregulatory moleculesAnti-tumor responsesTumor-associated macrophagesCell lung cancerImmune cell functionNSCLC cell linesPD-1Tumor killingBlocker therapyCD8+LAG-3Immune landscapeImmunoregulatory phenotypeSingle-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes
Uhm C, Gu J, Ju W, Pizzella S, Oktay H, Peng J, Guariglia S, Liu Y, Zhao H, Wang Y, Menon R, Zhong N. Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes. Cell & Bioscience 2025, 15: 1. PMID: 39773245, PMCID: PMC11705668, DOI: 10.1186/s13578-024-01343-0.Peer-Reviewed Original ResearchSpontaneous preterm birthPreterm birthExtravillous trophoblastDevelopment of spontaneous preterm birthOutcomes associated with preterm birthSingle-nucleus RNA sequencingMaternal-fetal interfacePreterm birth subtypesImmune cell recruitmentSmooth muscle contractionDevelopment of effective therapeutic strategiesEffective therapeutic strategyMatrix metalloproteinase activityPremature ruptureNeurodevelopmental outcomesTumor necrosis factor signalingPlacental trophoblastsPathological developmentVascular dysregulationNeonatal healthPPROMCell recruitmentHeightened inflammationTherapeutic strategiesVascular remodeling
2024
Ryanodine Receptor 3 (RYR3) as a Candidate Modifier of Aneurysm Formation in ADPKD
Roy K, Gulati A, Gu J, Shaw M, Sun Z, Besse W, Watnick T, Somlo S. Ryanodine Receptor 3 (RYR3) as a Candidate Modifier of Aneurysm Formation in ADPKD. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024xfh9af06. DOI: 10.1681/asn.2024xfh9af06.Peer-Reviewed Original ResearchPOS1390 SINGLE-CELL PROFILING IDENTIFIES PERIPHERAL IMMUNE SIGNATURE OF CORONARY ARTERY DISEASE IN SLE PATIENTS
LI C, Osmani L, Gu J, Zhao H, Kang I, Bucala R, Dong X. POS1390 SINGLE-CELL PROFILING IDENTIFIES PERIPHERAL IMMUNE SIGNATURE OF CORONARY ARTERY DISEASE IN SLE PATIENTS. Annals Of The Rheumatic Diseases 2024, 83: 929. DOI: 10.1136/annrheumdis-2024-eular.412.Peer-Reviewed Original Research
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