High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats
de Noronha S, de Moraes L, Hassell J, Stamper C, Arnold M, Heinze J, Foxx C, Lieb M, Cler K, Karns B, Jaekel S, Loupy K, Silva F, Chianca-Jr. D, Lowry C, de Menezes R. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological Research 2024, 57: 23. PMID: 38705984, PMCID: PMC11071217, DOI: 10.1186/s40659-024-00505-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyBehavior, AnimalBrain-Gut AxisDiet, High-FatGastrointestinal MicrobiomeMaleObesityRatsRats, Sprague-DawleySignal TransductionConceptsDefensive behavioral responsesSerotonergic gene expressionDorsal raphe nucleusSlc6a4 mRNA expressionBehavioral responsesMicrobiome-gut-brainRaphe nucleusAnxiety-related behavioral responsesBrain serotonergic systemSerotonergic brain systemAnxiety-like behaviorMale ratsAxis signalingHigh-fat dietBrain systemsSerotonergic systemAssociated with stressCommunity compositionGut microbiomeGene expressionAbundance of BlautiaHTR1AGut microbiome diversityTPH2SLC6A4