2004
Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women.
Ren Z, Cai Q, Shu X, Cai H, Li C, Yu H, Gao Y, Zheng W. Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 1290-5. PMID: 15298948, DOI: 10.1158/1055-9965.1290.13.8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionBase SequenceBiomarkers, TumorBreast NeoplasmsCase-Control StudiesChinaConfidence IntervalsFemaleGenetic Predisposition to DiseaseHumansIncidenceInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsMiddle AgedMolecular Sequence DataOdds RatioPolymerase Chain ReactionPolymorphism, GeneticPopulation SurveillanceReference ValuesRisk AssessmentConceptsInsulin-like growth factorIGFBP-3 protein levelsBreast cancer riskBreast cancerVariant allelesIGFBP3 polymorphismsIGFBP-3IGFBP3 geneCancer riskElevated riskRisk genotypesActions of IGFsIncident breast cancer patientsChinese womenIGFBP-3 levelsIGF binding proteinBreast cancer patientsGenetic polymorphismsIGFBP-3 proteinProtein levelsCase-control studyDose-response mannerCancer patientsOdds ratioPolymorphism A
1999
Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation
Yu H, Mistry J, Nicar M, Khosravi M, Diamandis A, van Doorn J, Juul A. Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation. Journal Of Clinical Laboratory Analysis 1999, 13: 166-172. PMID: 10414596, PMCID: PMC6808158, DOI: 10.1002/(sici)1098-2825(1999)13:4<166::aid-jcla5>3.0.co;2-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood CirculationBlood ProteinsCarrier ProteinsFemaleGlycoproteinsHumansImmunoassayInsulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding Protein 6Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMaleMiddle AgedProtein BindingReceptors, SomatomedinReference ValuesSomatomedinsConceptsInsulin-like growth factorTotal insulin-like growth factorIGF-II levelsIGFBP-3IGFBP-6Growth factorLevels of IGFFree insulin-like growth factorIGFBP-2 levelsIGFBP-2Plasma levelsEpidemiological studiesReference rangeNormal populationPubertyBlood circulationAgeSerumBirthCell growthALSMalesFemalesSimilar patternGender
1998
The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency
Juul A, Møller S, Mosfeldt-Laursen E, Rasmussen M, Scheike T, Pedersen S, Kastrup K, Yu H, Mistry J, Rasmussen S, Müller J, Henriksen J, Skakkebæk N. The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 4408-4415. PMID: 9851786, DOI: 10.1210/jcem.83.12.5311.Peer-Reviewed Original ResearchConceptsAcid-labile subunitIGFBP-3GH deficiencyALS levelsHepatosplanchnic releaseNormal age-related rangesChildhood-onset GH deficiencyInsulin-like growth factorAge-related rangeSignificant arteriovenous gradientNormal GH responseGH secretory statusConcentrations of IGFLiver vein catheterizationGrowth hormone deficiencyCirculating ConcentrationsGH responseGHD patientsVein catheterizationSecretory statusArteriovenous gradientHormone deficiencyHealthy subjectsDiagnostic utilityIGF
1997
Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess
Melegos D, Yu H, Ashok M, Wang C, Stanczyk F, Diamandis E. Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 777-780. PMID: 9062481, DOI: 10.1210/jcem.82.3.3792.Peer-Reviewed Original ResearchConceptsProstate-specific antigenMarker of androgen excessSerum prostate-specific antigenHirsute womenReceiver operating characteristicAndrogen actionAndrogen excessLevels of prostate-specific antigenProstate-specific antigen levelProstate-specific antigen geneFemale serumAction of steroid hormone receptorsMarker of androgen actionAlpha-androstanediol glucuronideSerum PSA levelsFerriman-Gallwey scorePotential new markerSteroid hormone receptorsPSA levelsProstate-specificHyperandrogenic statePatient ageAlpha-androstanediolAlpha-AgBiochemical markers
1996
Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue
Yu H, Diamandis E, Levesque M, Giai M, Roagna R, Ponzone R, Sismondi P, Monne M, Croce C. Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. Breast Cancer Research And Treatment 1996, 40: 171-178. PMID: 8879683, DOI: 10.1007/bf01806212.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBreastBreast DiseasesBreast NeoplasmsChildFemaleHumansMiddle AgedProstate-Specific AntigenReference ValuesConceptsBenign breast diseaseProstate-specific antigenNormal breast tissueBreast diseaseBreast tumorsBreast tissueBreast cancerSpecific antigenBreast cancer tissuesSteroid hormone actionPSA positivityPSA levelsDisease stageProstatic adenocarcinomaPSA productionTumor markersStage IBBD tissueCancer tissuesFemale breastSteroid hormonesLow expressionPolymerase chain reaction amplificationTumorsChain reaction amplificationAssay of prostate-specific antigen from whole blood spotted on filter paper and application to prostate cancer screening.
Hoffman B, Yu H, Diamandis E. Assay of prostate-specific antigen from whole blood spotted on filter paper and application to prostate cancer screening. Clinical Chemistry 1996, 42: 536-544. PMID: 8605670, DOI: 10.1093/clinchem/42.4.536.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate cancerOccult prostate cancerWhole bloodWhole blood concentrationsExtracts of bloodFilter paper procedureMicrograms/L.Cancer screeningPSA recoverySy/xBloodPlasma fractionConcentration of PSARegression analysisCancerAntigenCentralized laboratoriesMicroL of bufferMicroLFilter paperPaper discsHematocritRecoveryMonths
1995
Prostate-specific antigen in serum of women with breast cancer
Giai M, Yu H, Roagna R, Ponzone R, Katsaros D, Levesque M, Diamandis E. Prostate-specific antigen in serum of women with breast cancer. British Journal Of Cancer 1995, 72: 728-731. PMID: 7545417, PMCID: PMC2033864, DOI: 10.1038/bjc.1995.401.Peer-Reviewed Original ResearchConceptsSerum prostate-specific antigenProstate-specific antigenBreast cancer patientsBreast cancerPSA levelsCancer patientsTumor cytosolsBreast tumorsPSA concentrationFree prostate-specific antigenSerum of womenFavorable prognostic indicatorSerum PSA levelsNormal male serumFemale breast tumorsBreast cancer diagnosisPresurgical seraPrognostic indicatorSurgical removalNormal breastMale serumCancerSerumCancer diagnosisTumorsProstate-specific antigen immunoreactivity in amniotic fluid.
Yu H, Diamandis E. Prostate-specific antigen immunoreactivity in amniotic fluid. Clinical Chemistry 1995, 41: 204-210. PMID: 7533063, DOI: 10.1093/clinchem/41.2.204.Peer-Reviewed Original ResearchConceptsProtease prostate-specific antigenAmniotic fluidAlpha-fetoproteinGestational ageProstate-specific antigen immunoreactivitySensitive immunofluorometric procedureHigh alpha-fetoproteinHigher PSA concentrationsProstate-specific antigenNormal fetal developmentGrowth factor regulatorSerine protease prostate-specific antigenNonpregnant womenMaternal serumPregnant womenAntigen immunoreactivityBreast tumorsFetal developmentPSA concentrationImmunofluorometric procedurePregnancySignificant correlationWomenAgeSyndrome
1993
Ultrasensitive time-resolved immunofluorometric assay of prostate-specific antigen in serum and preliminary clinical studies.
Yu H, Diamandis E. Ultrasensitive time-resolved immunofluorometric assay of prostate-specific antigen in serum and preliminary clinical studies. Clinical Chemistry 1993, 39: 2108-2114. PMID: 7691442, DOI: 10.1093/clinchem/39.10.2108.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlkaline PhosphataseAntibodies, MonoclonalChromatography, High Pressure LiquidEdetic AcidFemaleFluoroimmunoassayHumansMaleMiddle AgedNeoplasm Recurrence, LocalProstate-Specific AntigenProstatectomyProstatic NeoplasmsQuality ControlReference ValuesSensitivity and SpecificityTerbiumConceptsL PSAPolyclonal detection antibodyUltrasensitive time-resolved immunofluorometric assaySensitive prostate specific antigenPSA antibodyDetection antibodyTime-resolved fluorometryTime-resolved immunofluorometric assayUltrasensitive methodProstate-specific antigenMicrotiter wellsImmunofluorometric assayClinical applicationStreptavidinExtreme sensitivityAssays