2023
Genetic variants of glucose metabolism and exposure to smoking in African American breast cancer.
Jung S, Papp J, Sobel E, Pellegrini M, Yu H. Genetic variants of glucose metabolism and exposure to smoking in African American breast cancer. Endocrine Related Cancer 2023, 30 PMID: 36705562, PMCID: PMC10095926, DOI: 10.1530/erc-22-0184.Peer-Reviewed Original ResearchConceptsInsulin resistanceBC riskLifestyle factorsSingle nucleotide polymorphismsAA womenRisk genotypesAfrican American postmenopausal womenAfrican-American breast cancerRisk of BCBreast cancer developmentDose-dependent mannerPostmenopausal womenPositive BCPredictive markerRisk factorsFemale hormonesBreast cancerGlucose metabolismMetabolic biomarkersGene-environment interaction analysisSmokingPreventive interventionsCancer developmentWhite womenIndividual single nucleotide polymorphisms
2016
Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer
Yu H, Irwin M. Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer. Energy Balance And Cancer 2016, 11: 251-264. DOI: 10.1007/978-3-319-41610-6_11.Peer-Reviewed Original ResearchDNA methylationTumor suppressor genePhysical activityEpigenetic regulationSuppressor geneCancer riskGenome-wide methylationBetter patient survivalBreast cancer patientsPro-inflammatory cytokinesBreast cancer riskSex steroid hormonesLower cancer riskMitogenic growth factorsEntire genomeMolecular mechanismsInsulin resistancePatient survivalCancer patientsMethylationMore profound impactsCancer preventionBreast cancerDisease outcomeHealthy individuals
2006
266 NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN THE METABOLIC SYNDROME.
Huang J, Parish R, Yu H, Bass P, Mansi I, Kennen E, Davis T, Carden D. 266 NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN THE METABOLIC SYNDROME. Journal Of Investigative Medicine 2006, 54: s303. DOI: 10.2310/6650.2005.x0008.265.Peer-Reviewed Original ResearchLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolLow high-density lipoprotein cholesterolMetabolic syndromeLipoprotein cholesterolCoronary artery disease preventionPrevalence of MSDiagnosis of MSPercent of patientsPrevalence of dyslipidemiaNon-HDL cholesterolDensity lipoprotein cholesterolHigher atherogenic potentialCardiovascular morbidityCentral obesityLipid managementElevated BPElevated triglyceridesHigh triglyceridesMS patientsAggressive loweringNCEP criteriaInsulin resistanceLipid therapyPatient population
2004
Evaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma
Malin A, Dai Q, Yu H, Shu X, Jin F, Gao Y, Zheng W. Evaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma. Cancer 2004, 100: 694-700. PMID: 14770423, PMCID: PMC1780270, DOI: 10.1002/cncr.20023.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast carcinomaC-peptideIGFBP-3Insulin resistanceIGF-1Odds ratioShanghai Breast Cancer StudyGrowth factorBreast carcinoma riskHigh blood levelsBreast carcinoma casesCase-control pairsDose-response mannerBreast Cancer StudyCurrent studyHighest quartileBlood levelsLowest quartileCarcinoma casesCarcinoma riskHigh riskHigh levelsCarcinomaSignificant twofold
2002
Insulin Resistance, IGFs and Energy Balance on the Risk of Breast Cancer
Malin A, Zheng W, Yu H. Insulin Resistance, IGFs and Energy Balance on the Risk of Breast Cancer. 2002 DOI: 10.21236/ada406834.Peer-Reviewed Original ResearchShanghai Breast Cancer StudyBreast cancer riskC-peptide levelsBreast cancerC-peptideCancer riskInsulin resistanceBlood C-peptide levelsPre-treatment blood samplesBreast cancer casesSubset of subjectsBreast Cancer StudyIGF bioavailabilityBlood levelsFat distributionPotential joint effectsCancer casesIGF-1Physical activityBlood samplesEpidemiological studiesBody weightIGFCancerGrowth factor