2016
Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma
Buas MF, He Q, Johnson LG, Onstad L, Levine DM, Thrift AP, Gharahkhani P, Palles C, Lagergren J, Fitzgerald RC, Ye W, Caldas C, Bird NC, Shaheen NJ, Bernstein L, Gammon MD, Wu AH, Hardie LJ, Pharoah PD, Liu G, Iyer P, Corley DA, Risch HA, Chow WH, Prenen H, Chegwidden L, Love S, Attwood S, Moayyedi P, MacDonald D, Harrison R, Watson P, Barr H, deCaestecker J, Tomlinson I, Jankowski J, Whiteman DC, MacGregor S, Vaughan TL, Madeleine MM. Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma. Gut 2016, 66: 1739. PMID: 27486097, PMCID: PMC5296402, DOI: 10.1136/gutjnl-2016-311622.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBarrett EsophagusCytokinesEsophageal NeoplasmsFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyGerm-Line MutationGlutathione TransferaseHLA AntigensHumansInflammationMaleMiddle AgedNF-kappa BOxidative StressPolymorphism, Single NucleotidePrincipal Component AnalysisProstaglandin-Endoperoxide SynthasesRisk FactorsSignal TransductionConceptsBarrett's esophagusBE casesSingle nucleotide polymorphismsGermline variationOesophageal adenocarcinoma incidenceHuman leucocyte antigenInflammation-related pathwaysSymptomatic refluxSystemic inflammationAdenocarcinoma incidenceOesophageal adenocarcinomaOA pathogenesisInflammatory processLeucocyte antigenOA casesRisk factorsCOX pathwayBE riskOA riskDisease riskEsophagusStrong expression quantitative trait locusGenetic susceptibilityNuclear factorExpression quantitative trait loci
2015
Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett’s Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium
Lagergren K, Ek WE, Levine D, Chow WH, Bernstein L, Casson AG, Risch HA, Shaheen NJ, Bird NC, Reid BJ, Corley DA, Hardie LJ, Wu AH, Fitzgerald RC, Pharoah P, Caldas C, Romero Y, Vaughan TL, MacGregor S, Whiteman D, Westberg L, Nyren O, Lagergren J. Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett’s Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium. PLOS ONE 2015, 10: e0138738. PMID: 26406593, PMCID: PMC4583498, DOI: 10.1371/journal.pone.0138738.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaADP-ribosyl Cyclase 1AromataseBarrett EsophagusEsophageal NeoplasmsEstrogen Receptor alphaEstrogen Receptor betaFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMembrane GlycoproteinsOxytocinPolymorphism, Single NucleotideReceptors, OxytocinSex FactorsConceptsKey genesGenetic variantsGenes of relevanceGene-based approachesAssociation studiesGenesOxytocin pathwaysGenetic epidemiological studiesEstrogen receptor alphaRisk of OACRisk of BEPathwayReceptor alphaOesophageal adenocarcinomaBarrett's esophagusNorth AmericaReplicationPolymorphismEstrogen pathwayVariantsStrong male predominanceOAC patientsMalesBO patientsMale predominance
2011
Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium
Freedman ND, Murray LJ, Kamangar F, Abnet CC, Cook MB, Nyrén O, Ye W, Wu AH, Bernstein L, Brown LM, Ward MH, Pandeya N, Green AC, Casson AG, Giffen C, Risch HA, Gammon MD, Chow WH, Vaughan TL, Corley DA, Whiteman DC. Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium. Gut 2011, 60: 1029. PMID: 21406386, PMCID: PMC3439838, DOI: 10.1136/gut.2010.233866.Peer-Reviewed Original ResearchConceptsOesophageal squamous cell carcinomaRisk of OACOesophageal adenocarcinomaAlcohol intakeRisk of OSCCGastro-oesophageal refluxModerate alcohol intakeBody mass indexSquamous cell carcinomaSummary risk estimatesFuture prospective studiesApparent inverse associationCase-control studyHigh alcohol consumptionEsophageal Adenocarcinoma ConsortiumRandom-effects modelLogistic regression modelsCohort studyTobacco smokingMass indexOSCC casesModerate intakeOesophagogastric junctionProspective studyCell carcinoma
2001
Pro-inflammatory genotypes of IL-1β, TNF-α and IL-10 increase risk of distal gastric cancer but not of cardia or oesophageal adenocarcinomas
El-Omar E, Chow W, Gammon M, Vaughan T, Risch H, Fraumeni J. Pro-inflammatory genotypes of IL-1β, TNF-α and IL-10 increase risk of distal gastric cancer but not of cardia or oesophageal adenocarcinomas. Gastroenterology 2001, 120: a86. DOI: 10.1016/s0016-5085(08)80425-8.Peer-Reviewed Original ResearchPro-inflammatory genotypes of IL-1β, TNF-α and IL-10 increase risk of distal gastric cancer but not of cardia or oesophageal adenocarcinomas
ELOMAR E, CHOW W, GAMMON M, VAUGHAN T, RISCH H, FRAUMENIJR J. Pro-inflammatory genotypes of IL-1β, TNF-α and IL-10 increase risk of distal gastric cancer but not of cardia or oesophageal adenocarcinomas. Gastroenterology 2001, 120: a86-a86. DOI: 10.1016/s0016-5085(01)80425-x.Peer-Reviewed Original Research