2019
A Pathway Analysis of Hereditary Hemochromatosis-related Genes and Pancreatic Ductal Adenocarcinoma Risk (FS11-05-19)
Julián-Serrano S, Yu K, Yuan F, Wheeler W, Karimi P, Amundadottir L, Jacobs E, Kraft P, Li D, Petersen G, Risch H, Wolphin B, Klein A, Stolzenberg-Solomon R. A Pathway Analysis of Hereditary Hemochromatosis-related Genes and Pancreatic Ductal Adenocarcinoma Risk (FS11-05-19). Current Developments In Nutrition 2019, 3: nzz037.fs11-05-19. PMCID: PMC6573995, DOI: 10.1093/cdn/nzz037.fs11-05-19.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaHereditary hemochromatosis geneGenetic susceptibilityPDAC riskSingle nucleotide polymorphismsHereditary hemochromatosisHigh red meat intakeType 2 diabetes mellitusHemochromatosis geneRed meat intakePancreatic Cancer Case-Control ConsortiumIron-rich foodsType 2 diabetesPancreatic Cancer Cohort ConsortiumPancreatic ductal adenocarcinoma (PDAC) riskIntramural Research ProgramNational Cancer InstitutePathway analysisDiabetes mellitusAdenocarcinoma riskPrimary hemochromatosisRisk factorsChronic diseasesDuctal adenocarcinomaMeat intake
2017
Aspirin Use and Reduced Risk of Pancreatic Cancer
Risch HA, Lu L, Streicher SA, Wang J, Zhang W, Ni Q, Kidd MS, Yu H, Gao YT. Aspirin Use and Reduced Risk of Pancreatic Cancer. Cancer Epidemiology Biomarkers & Prevention 2017, 26: 68-74. PMID: 27999143, PMCID: PMC5225096, DOI: 10.1158/1055-9965.epi-16-0508.Peer-Reviewed Original ResearchConceptsPancreatic cancerAspirin useRegular useConfidence intervalsLong-term aspirin useControl subjects frequencyLow-dose aspirinAvoidance of smokingBody mass indexPopulation-based studyUnconditional logistic regressionABO blood groupRisk-benefit analysisAspirin typeCagA seropositivityDiabetes mellitusMass indexCigarette smokingCardiovascular diseaseAspirinCancerCertain cancersLogistic regressionBlood groupSubjects frequency
2016
Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma
McWilliams RR, Maisonneuve P, Bamlet WR, Petersen GM, Li D, Risch HA, Yu H, Fontham ET, Luckett B, Bosetti C, Negri E, La Vecchia C, Talamini R, de Mesquita H, Bracci P, Gallinger S, Neale RE, Lowenfels AB. Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma. Pancreas 2016, 45: 311-316. PMID: 26646264, PMCID: PMC4710562, DOI: 10.1097/mpa.0000000000000392.Peer-Reviewed Original ResearchConceptsEarly onset pancreatic cancerPancreatic cancerAge-dependent effectsRisk factorsFamily historySex-matched control subjectsDiagnosis of PCCase-control studyLogistic regression analysisPC patientsDiabetes mellitusAlcohol intakeControl subjectsOdds ratioPancreatic adenocarcinomaEarly onsetPatientsOlder adultsStrong associationObesitySmokingRegression analysisRiskAssociationComprehensive assessment
2015
Detectable Symptomatology Preceding the Diagnosis of Pancreatic Cancer and Absolute Risk of Pancreatic Cancer Diagnosis
Risch HA, Yu H, Lu L, Kidd MS. Detectable Symptomatology Preceding the Diagnosis of Pancreatic Cancer and Absolute Risk of Pancreatic Cancer Diagnosis. American Journal Of Epidemiology 2015, 182: 26-34. PMID: 26049860, PMCID: PMC4479115, DOI: 10.1093/aje/kwv026.Peer-Reviewed Original ResearchConceptsPancreatic cancer diagnosisAbsolute riskPancreatic cancerRecent diagnosisRisk factorsEnd Results (SEER) incidence dataUS Surveillance EpidemiologyCancer diagnosisCurrent cigarette smokingLow lifetime riskABO blood groupDiabetes mellitusSurveillance EpidemiologyCigarette smokingSurvival durationLifetime riskHigh riskPancreatic causesCancerBlood groupRisk estimatesDiagnosisIncidence dataSymptomatologyRisk
2003
Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity
Risch HA. Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity. Journal Of The National Cancer Institute 2003, 95: 948-960. PMID: 12837831, DOI: 10.1093/jnci/95.13.948.Peer-Reviewed Original ResearchConceptsPancreatic cancerGastric acidityRisk of nonsmokersConsumption of fruitsCurrent smokersDiabetes mellitusChronic pancreatitisCigarette smokingColorectal cancerCytokine mechanismsCancer deathDietary factorsDuodenal acidityRisk factorsEpidemiologic reviewFrequent causeHigh riskLower riskN-nitroso compoundsHelicobacter pyloriCancerGermline mutationsHost genetic variationRiskAnimal foods
1988
DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE URINARY BLADDER
RISCH H, BURCH J, MILLER A, HILL G, STEELE R, HOWE G. DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE URINARY BLADDER. American Journal Of Epidemiology 1988, 127: 1179-1191. PMID: 3369417, DOI: 10.1093/oxfordjournals.aje.a114911.Peer-Reviewed Original ResearchConceptsBladder cancerDietary factorsLow-calorie foodsConditional logistic regression methodsCalorie foodsIntake of cholesterolCase-control studyAge 20 yearsLife-style factorsIncidence of cancerHistory of exposureLack of associationOdds ratio estimatesArtificial sweetenersArea of residenceAverage daily intakeDiabetes mellitusCigarette smokingSubsequent riskCancer casesUrinary bladderRelevant food itemsMild increaseCancerDaily intake