Douglas Brackney
Professor Adjunct of Epidemiology (Microbial Diseases)DownloadHi-Res Photo
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Professor Adjunct of Epidemiology (Microbial Diseases)
Assistant Clinical Professor of Epidemiology (Microbial Diseases)
Biography
Dr. Brackney is an Assistant Scientist at the Connecticut Agricultural Experiment Station and Adjunct Assistant Clinical Professor of Epidemiology. He received his degree in Microbiology, Immunology and Pathology from Colorado State University in 2007 with an emphasis in arbovirology and vector biology. After post-doctoral fellowships at the University of New Mexico and Colorado State University, he moved with his family to the New Haven area in 2014 to join the Experiment Station. His laboratory is interested in understanding the cellular and molecular mechanisms mediating arbovirus-mosquito midgut interactions in hopes of identifying critical factors that can be targeted for novel control interventions.
Last Updated on July 01, 2024.
Appointments
Epidemiology of Microbial Diseases
Assistant Professor AdjunctPrimaryEpidemiology of Microbial Diseases
Professor AdjunctPrimary
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Douglas Brackney's published research.
Publications Timeline
A big-picture view of Douglas Brackney's research output by year.
Nathan Grubaugh, PhD
Chantal Vogels, PhD
Albert Ko
Philip Armstrong
Akiko Iwasaki, PhD
Benjamin Goldman-Israelow, MD, PhD
67Publications
8,376Citations
Publications
2025
Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut
Nattoh G, Armstrong P, Brackney D. Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut. PLOS Pathogens 2025, 21: e1013617. PMID: 41144442, PMCID: PMC12558446, DOI: 10.1371/journal.ppat.1013617.Peer-Reviewed Original ResearchAltmetricConceptsImplications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes
Johnson R, Breban M, Nolan B, Sodeinde A, Ott I, Ross P, Gu X, Grubaugh N, Perkins T, Brackney D, Vogels C. Implications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes. Nature Communications 2025, 16: 6971. PMID: 40730791, PMCID: PMC12307751, DOI: 10.1038/s41467-025-62352-2.Peer-Reviewed Original ResearchCitationsAltmetricMosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti
Hall D, Johnson R, Kwon H, Ferdous Z, Laredo-Tiscareño S, Blitvich B, Brackney D, Smith R. Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti. Nature Communications 2025, 16: 5891. PMID: 40593674, PMCID: PMC12214649, DOI: 10.1038/s41467-025-61139-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVirus infectionImmune cellsAdoptive transfer experimentsImmune cell populationsZika virus infectionMosquito hostPhagocyte depletionSalivary glandsPeripheral tissuesVirus disseminationCell populationsPublic health importanceZika virusMosquito-borne arbovirusesInfectionArbovirus infectionDengue virusAnnual infectionsInvertebrate systemsVertebrate systemsVirusInfected hemocytesMosquito tissuesHealth importanceHemocytesUsing geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut
Desiato J, Chan G, Palmeri M, Cantoni J, Cozens D, Linske M, Brackney D, Stafford K, Banach D. Using geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut. Journal Of Medical Entomology 2025, 62: 1026-1031. PMID: 40341955, DOI: 10.1093/jme/tjaf055.Peer-Reviewed Original ResearchAltmetricConceptsDepartment of Public HealthConnecticut Department of Public HealthCases of anaplasmosisClinical cases of anaplasmosisIncidence ratePublic healthSurveillance dataPublic health interventionsPotential associationI. scapularisHealth interventionsTick surveillance dataConnecticut Agricultural Experiment StationIdentified geographic areasAgricultural Experiment StationEvaluate potential associationsIxodes scapularis ticksBacterium Anaplasma phagocytophilumPrevalence dataActive tick surveillanceClinical casesQuesting I. scapularisSpearman rank correlationIncreased riskAnaplasma phagocytophilumFunctional connectivity for white-tailed deer drives the distribution of tick-borne pathogens in a highly urbanized setting
Lilly M, Davis M, Kross S, Konowal C, Gullery R, Lee S, Poulos K, Gregory N, Nagy C, Cozens D, Brackney D, del Pilar Fernandez M, Diuk-Wasser M. Functional connectivity for white-tailed deer drives the distribution of tick-borne pathogens in a highly urbanized setting. Landscape Ecology 2025, 40: 87. PMID: 40270782, PMCID: PMC12011924, DOI: 10.1007/s10980-025-02101-4.Peer-Reviewed Original ResearchCitationsConceptsUrbanization gradientCircuit theory methodsWhite-tailed deerImpact of functional connectivityWildlife camerasEcological processesDeer movementsCascading effectsUrban greenspaceBlacklegged tick populationsManagement plansUrban landscapeTick abundanceDeerTick populationsNeighborhood scaleDisease emergenceGreenspaceWildlifeUrban areasBlacklegged tickUrban environmentLong IslandUrbanizationAbundance
2024
MosAIC: An annotated collection of mosquito-associated bacteria with high-quality genome assemblies
Foo A, Brettell L, Nichols H, Students 2, Muñoz M, Lysne J, Dhokiya V, Hoque A, Brackney D, Caragata E, Hutchinson M, Jacobs-Lorena M, Lampe D, Martin E, Moro C, Povelones M, Short S, Steven B, Xu J, Paustian T, Rondon M, Hughes G, Coon K, Heinz E. MosAIC: An annotated collection of mosquito-associated bacteria with high-quality genome assemblies. PLOS Biology 2024, 22: e3002897. PMID: 39546548, PMCID: PMC11633956, DOI: 10.1371/journal.pbio.3002897.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenomic dataBacterial isolatesGenome assemblySpecies pangenomeHigh-quality draft genome assemblyCollection of bacterial isolatesDraft genome assemblyCluster of genesCausative agentCausative agent of malariaVertebrate microbiomePhylogenomic analysisMosquito microbiomeAmplicon dataTaxonomic resolutionSequence dataIsolate collectionAgent of malariaBacterial familiesHost associationsMicrobiome manipulationDisease-causing agentsHuman pathogensSpecies representationMosquito hostMultiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera
Ferdous Z, Dieme C, Sproch H, Kramer L, Ciota A, Brackney D, Armstrong P. Multiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera. Parasites & Vectors 2024, 17: 432. PMID: 39427222, PMCID: PMC11490111, DOI: 10.1186/s13071-024-06531-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAedes aegyptiMidgut infection ratesMultiple bloodmealsVector competence of Aedes aegyptiVirus vectorsLaboratory vector competence studiesVector competence studiesMosquito generaFeeding regimenBiting midgesCulex quinquefasciatusPost-infectionOropouche virusWest Nile virusBloodmealVirus disseminationVector competenceEscape barrierFeeding behaviorDissemination of arbovirusesAedes albopictus mosquitoesAedes triseriatusAedesFemale mosquitoesNile virusThe West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles
Huston N, Tsao L, Brackney D, Pyle A. The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2312080121. PMID: 38985757, PMCID: PMC11260092, DOI: 10.1073/pnas.2312080121.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWest Nile virus genomeWest Nile virusPositive-sense RNA virusesFunctional roleArthropod cell linesRiboregulatory elementsGenome foldingFlaviviral genomeRNA genomeIncreasing global threatVirus genomeGenomeRNA virusesStructural homologyHost-dependentSecondary structureLack of effective therapeuticsFunctional validationLocked nucleic acidStructural insightsRNA drugsCell linesArthropod-borneNucleic acidsAntisense locked nucleic acidInvestigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics
Johnson R, Stopard I, Byrne H, Armstrong P, Brackney D, Lambert B. Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics. PLOS Pathogens 2024, 20: e1011975. PMID: 38557892, PMCID: PMC11008821, DOI: 10.1371/journal.ppat.1011975.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBasal lamina layersInfection dynamicsYellow fever virusEpidemics of severe diseaseMidgut escape barrierDengue virusVirus population dynamicsAmount of virusEstablishment of infectionDose-dependentlyMosquito feeding behaviorDEN virusesExtrinsic incubation periodFever virusMidgut epitheliumBlood feedingFeeding eventsMidgutViral infection dynamicsZika virusAedes aegyptiCourse of infectionEscape barrierAedes albopictusIncubation periodField Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida.
Armstrong P, Anderson J, Sharma R, Misencik M, Bransfield A, Vossbrinck C, Brackney D. Field Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida. American Journal Of Tropical Medicine And Hygiene 2024, 110: 968-970. PMID: 38531101, PMCID: PMC11066360, DOI: 10.4269/ajtmh.23-0799.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCulex quinquefasciatusMultiple mouse tissuesVector competenceDisseminated infectionNucleotide identityTexas isolatesL segmentField isolatesS segmentFlorida strainBlood mealMidgut infectionDisease signsMouse tissuesLaboratory trialsCulex erraticusIntradermal inoculationAedes aegyptiQuinquefasciatusCulex mosquitoesCulexIsolatesSouthern FloridaSuckling miceVirus transmission
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