Denise Esserman, PhD
Professor of BiostatisticsDownloadHi-Res Photo
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Professor of Biostatistics
Biography
Denise Esserman joined the Yale School of Public Health faculty in 2014 as an associate professor of biostatistics. She is interested in methods related to clustered randomized trials and the impact of the ICC and other factors on calculating sample size. As a member of the Yale Center for Analytical Sciences, she collaborates with a number of departments at the Yale School of Medicine, including the Clinical and Translational Science Award Program, Patient-Centered Outcomes Research Institute, and the Cancer Center. She has reviewed articles for the American Journal of Epidemiology, Arteriosclerosis, Thrombosis and Vascular Biology; Statistics in Biopharmaceutical Research; Clinical Trials; and Obesity. Esserman earned her doctorate at Columbia University and has since taught at the University of North Carolina, Chapel Hill.
Last Updated on April 07, 2025.
Appointments
Biostatistics
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Columbia University (2006)
- MS
- University of Georgia (2001)
Research
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Overview
Medical Research Interests
Biostatistics; Longitudinal Studies; Public Health; Randomized Controlled Trial; Sampling Studies
ORCID
0000-0003-1326-9618
Research at a Glance
Yale Co-Authors
Frequent collaborators of Denise Esserman's published research.
Publications Timeline
A big-picture view of Denise Esserman's research output by year.
Research Interests
Research topics Denise Esserman is interested in exploring.
Michael Kane, PhD, MA, MS
Fan Li, PhD
Erich J Greene, PhD
Ondrej Blaha, PhD
Frederick (Rick) Lewis Altice, MD, MA
Amy Justice, MD, PhD
62Publications
1,487Citations
Longitudinal Studies
Publications
2026
511 Building Consensus to Define a Diagnostic Entity to Capture When Benefits of Long-Term Opioid Therapy No Longer Outweigh Harms: Preliminary Findings from a Scoping Review
Edmond S, Grant A, Lee F, Su S, Black A, Esserman D, DeBar L, Becker W. 511 Building Consensus to Define a Diagnostic Entity to Capture When Benefits of Long-Term Opioid Therapy No Longer Outweigh Harms: Preliminary Findings from a Scoping Review. Journal Of Pain 2026, 41: 106158. DOI: 10.1016/j.jpain.2025.106158.Peer-Reviewed Original ResearchA Cluster Randomized Trial of a Vaccination Communication Educational Intervention: Impact on COVID-19 Vaccine Uptake in Veterans
Seal K, Kaplan A, Manuel J, Bertenthal D, Purcell N, DeRonne B, Oliver K, Esserman D, McCamish N, Mesidor M, Griffin B, Borsari B, Woodruff N, Usman H, Pyne J. A Cluster Randomized Trial of a Vaccination Communication Educational Intervention: Impact on COVID-19 Vaccine Uptake in Veterans. Journal Of General Internal Medicine 2026, 1-10. PMID: 41680545, DOI: 10.1007/s11606-026-10209-9.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPrimary care utilizationVeterans Health AdministrationUsual careEducational interventionCare utilizationVaccine uptakeImplementation-effectiveness trialPrimary care visitsVaccination communication interventionsCluster randomized trialCOVID-19 vaccine uptakeSignificant predictorsNon-white raceImplementation facilitatorsVA providersPredictors of vaccinationVA facilitiesCare visitsKey ResultsAmongHealthcare providersMI trainingMeasuresPrimary outcomesHealth AdministrationTargeted outreachCommunication interventionsA joint distribution for indexes of extremes with applications to climate change
Yu C, Kane M, Blaha O, Wei W, Esserman D, Zelterman D. A joint distribution for indexes of extremes with applications to climate change. Statistics And Its Interface 2026, 19: 197-209. DOI: 10.4310/sii.260108021930.Peer-Reviewed Original Research
2025
Factors contributing to COVID-19 vaccine hesitancy in Veterans later in the pandemic
Pyne J, Seal K, Manuel J, Kaplan A, Purcell N, Bertenthal D, Esserman D, Mesidor M, DeRonne B, Oliver K, Griffin B, Simpson H, Woodruff N, Borsari B, Tobey-Moore L, Usman H. Factors contributing to COVID-19 vaccine hesitancy in Veterans later in the pandemic. BMC Public Health 2025, 26: 295. PMID: 41413473, PMCID: PMC12831362, DOI: 10.1186/s12889-025-25716-3.Peer-Reviewed Original ResearchConceptsU.S. military veteransHealthcare providersVeterans Affairs Health Care SystemMilitary veteransUnvaccinated VeteransVA healthcare systemHealth care systemMultivariate logistic regression analysisPublic health concernProvider awarenessLogistic regression analysisPatient perspectiveCare systemPatient communicationMotivational interviewingRural residentsHealthcare systemConfidence surveySeasonal flu vaccineHousehold incomeVeteransCOVID-19ProvidersBackgroundVaccine hesitancyFlu vaccinationMTHFR allele and one-carbon metabolic profile predict severity of COVID-19
Petrova B, Syphurs C, Culhane A, Chen J, Chen E, Cotsapas C, Esserman D, Montgomery R, Kleinstein S, Smolen K, Mendez K, Network I, Lasky-Su J, Steen H, Levy O, Diray-Arce J, Kanarek N. MTHFR allele and one-carbon metabolic profile predict severity of COVID-19. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2509118122. PMID: 41410771, PMCID: PMC12745694, DOI: 10.1073/pnas.2509118122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSevere COVID-19High riskPublic health burdenHigh risk of severe diseaseEarly detection of patientsC677T alleleRisk of severe diseaseStudy of COVID-19 patientsEarly identificationRisk of severe COVID-19Early detectionDetection of patientsVaccine-acquired immunityHigher risk of severe COVID-19One-carbon metabolism pathwayBurden of SARS-CoV-2 infectionSARS-CoV-2 infectionSeverity of COVID-19COVID-19 patientsTargeted metabolite profilingVariant statusC677TRespiratory statusOne-carbon metabolismT alleleIntegrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial.
Machavariani E, Esserman D, Dumchev K, Filippovych M, Pykalo I, Ivasiy R, Madden L, Bromberg D, Haddad M, Morozova O, Oliveros D, Ahmad B, Dvoriak S, Altice F. Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial. Annals Of Internal Medicine 2025, 179: 177-186. PMID: 41359964, DOI: 10.7326/annals-25-01764.Peer-Reviewed Original ResearchCitationsAltmetricConceptsQuality health indicatorsHealth care usePrimary care settingPrimary careOpioid use disorderHealth indicatorsSpecialty clinicsCare useCare settingsOpioid agonist therapyTwo-group randomized controlled trialPrimary care centersSpecialty clinical careMiddle-income countriesRandomized Controlled TrialsProvider discomfortHealth outcomesHealth careComorbidity managementClinical careTwo-groupCareCare centerPrimary outcomeSpecialtyApproach to Quality Control Used for the HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis.
Nigwekar S, Dember L, Kalim S, Charytan D, Kuzla N, Kimmel P, Cukor D, Esserman D, Mishra P, Silva K, Steffen A, Vassilieva S, Williams J, Wetmore J. Approach to Quality Control Used for the HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis. Clinical Journal Of The American Society Of Nephrology 2025 PMID: 41414940, DOI: 10.2215/cjn.0000000970.Peer-Reviewed Original ResearchAltmetricThe Maximum Negative Hypergeometric Distribution
Yu C, Prishwalko K, Blaha O, Kane M, Wei W, Esserman D, Zelterman D. The Maximum Negative Hypergeometric Distribution. Journal Of Statistical Theory And Practice 2025, 19: 88. DOI: 10.1007/s42519-025-00502-x.Peer-Reviewed Original ResearchCorrection to: Fall Risk in Maintenance Hemodialysis Patients: A Secondary Analysis of the HOPE Consortium Trial
Charytan D, Moss A, Shalak M, Wu W, Dember L, Hsu J, Kuzla N, Esserman D, Kalim S, Kimmel P, Lockwood M, Miyawaki N, Pellegrino B, Pun P, Qamhiyeh R, Scherer J, Schrauben S, Weiner D, Mehrotra R. Correction to: Fall Risk in Maintenance Hemodialysis Patients: A Secondary Analysis of the HOPE Consortium Trial. Clinical Journal Of The American Society Of Nephrology 2025, 20: 1645-1645. PMID: 40991344, PMCID: PMC12614862, DOI: 10.2215/cjn.0000000912.Peer-Reviewed Original ResearchFall Risk in Maintenance Hemodialysis Patients
Charytan D, Moss A, Shalak M, Wu W, Dember L, Hsu J, Kuzla N, Esserman D, Kalim S, Kimmel P, Lockwood M, Miyawaki N, Pellegrino B, Pun P, Qamhiyeh R, Scherer J, Schrauben S, Weiner D, Mehrotra R. Fall Risk in Maintenance Hemodialysis Patients. Clinical Journal Of The American Society Of Nephrology 2025, 20: 1247-1258. PMID: 40663732, PMCID: PMC12445375, DOI: 10.2215/cjn.0000000775.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFrequent cause of fallsFall riskCause of fallsPatient-reported symptomsMedication useParticipants' homesChronic painSeverity of pain symptomsOutcomes of fallsPain Coping SkillsDemographic characteristicsCognitive behavioral therapy interventionPain symptomsHemodialysis unitBehavioral therapy interventionUS dialysis facilitiesCohort of maintenance hemodialysis patientsMaintenance hemodialysis patientsUsual careTherapy interventionsBackground FallsNo significant associationParticipants' yearsFrequent causeCoping skills
Clinical Trials
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Academic Achievements & Community Involvement
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- February 02, 2026
New “HOPE” for HIV Prevention and Addiction Treatment in Prisons
- August 05, 2024
Yale partnership seeks to improve HIV prevention and treatment training in Tbilisi, Georgia
- June 25, 2024Source: NIH Fogarty: Global Health Matters May/June 2024
Georgia rising: Partnerships help this nation grow
- June 05, 2024
YSPH appoints two new Biostatistics assistant professors
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