2024
Long-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil
Reis J, Azevedo J, de Oliveira A, de Oliveira Menezes A, Pedrosa M, dos Santos M, Ribeiro L, de Freitas H, Gouveia E, Teles M, da Glória Carvalho M, Reis M, Nascimento-Carvalho C, Verani J. Long-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil. Vaccine 2024, 42: 591-597. PMID: 38184393, PMCID: PMC10872423, DOI: 10.1016/j.vaccine.2023.12.055.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosInvasive pneumococcal diseaseLower-middle-income settingsPCV10 introductionInvasive pneumococcal disease incidenceProspective laboratory-based surveillanceNational infant immunization programsPre-PCV10 periodNon-vaccine serotypesRate ratiosInfant immunization programIncidence ratePneumococcal conjugate vaccineLaboratory-based surveillanceIPD incidenceImpact of PCV10Multiplex polymerase chain reactionMetropolitan region of SalvadorCompare ratesPCV10 serotypesLong-term impactSterile sitesQuellung reactionSerotype 15BVaccine-type
2023
Malaria and COVID-19 coinfection in a non-malaria-endemic area in Brazil
Rocha V, Brasil L, Gomes E, Khouri R, Ferreira G, Vasconcelos B, Gouveia M, Santos T, Reis M, Lacerda M. Malaria and COVID-19 coinfection in a non-malaria-endemic area in Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0598-2022. PMID: 37222351, PMCID: PMC10204151, DOI: 10.1590/0037-8682-0598-2022.Peer-Reviewed Original ResearchConceptsCOVID-19 coinfectionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Severe vivax malariaIntensive care unitSyndrome coronavirus 2Coronavirus disease 2019Transcription-quantitative PCR resultsSevere malariaCare unitCoronavirus 2Vivax malariaDifferential diagnosisDisease 2019Febrile diseaseEndemic areasPlasmodium vivaxEndemic regionsCoinfectionRapid testMalariaPCR resultsQuantitative PCRHypotension
2022
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Eyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil. ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.Peer-Reviewed Original ResearchConceptsInfection riskSignificant global public health burdenCommunity-based cohort studyGlobal public health burdenPublic health burdenAgents of leptospirosisExposure of interestYears of agePublic health interventionsHigh-risk communitiesJoint spatial modellingZoonotic spilloverCohort studyHuman infection riskMale genderSerological evidenceHealth burdenLeptospira infectionLeptospiral infectionInfection rateHealth interventionsEco-epidemiological studiesHealth surveillanceFundação de Amparo à PesquisaOswaldo Cruz FoundationStructural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional survey
Fofana MO, Nery N, Ticona J, de Andrade Belitardo EMM, Victoriano R, Anjos RO, Portilho MM, de Santana MC, dos Santos LL, de Oliveira D, Cruz JS, Muenker MC, Khouri R, Wunder EA, Hitchings MDT, Johnson O, Reis MG, Ribeiro GS, Cummings DAT, Costa F, Ko AI. Structural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional survey. PLOS Medicine 2022, 19: e1004093. PMID: 36074784, PMCID: PMC9499230, DOI: 10.1371/journal.pmed.1004093.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionSARS-CoV-2 infection riskUrban slumsSyndrome coronavirus 2 infectionSARS-CoV-2 seroprevalenceSARS-CoV-2 incidenceCoronavirus 2 infectionCross-sectional serosurveyMain outcome measuresUrban slum populationPresence of IgGSARS-CoV-2 spike proteinUrban slum communityCross-sectional surveyUrban slum residentsCumulative incidenceMedian ageRisk factorsOutcome measuresStudy populationHigh seroprevalenceMedian dailyPandemic waveGender distributionCOVID-19 vaccine hesitancy and associated factors according to sex: A population-based survey in Salvador, Brazil
Nery N, Ticona J, Cardoso C, Prates A, Vieira H, de Almeida A, da Silva Souza M, dos Reis O, Pellizzaro M, Portilho M, da Anunciação R, Victoriano R, dos Anjos R, Argibay H, Lima D, Mesquita I, Conceição W, Santana P, Oliveira E, Santana P, Brodskyn C, Fraga D, da Silva Solcà M, Reis M, Costa F, Ribeiro G. COVID-19 vaccine hesitancy and associated factors according to sex: A population-based survey in Salvador, Brazil. PLOS ONE 2022, 17: e0262649. PMID: 35061811, PMCID: PMC8782400, DOI: 10.1371/journal.pone.0262649.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccine hesitancyVaccine hesitancyCOVID-19 vaccineCOVID-19 riskCOVID-19 vaccine acceptanceInfluenza vaccination historyPopulation-based surveyCoronavirus disease 2019Less vaccine hesitancyHigher educational levelInfluenza vaccinationVaccination historyMultivariable analysisPrevious diagnosisVaccine acceptanceAssociated FactorsVaccine campaignDisease 2019VaccineComorbiditiesHesitancyCOVID-19VaccinationEducational levelWomen
2021
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
Jacob-Nascimento L, Carvalho C, Silva M, Kikuti M, Anjos R, Fradico J, Campi-Azevedo A, Tauro L, Campos G, dos Santos Moreira P, Portilho M, Martins-Filho O, Ribeiro G, Reis M. Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection. Frontiers In Immunology 2021, 12: 744183. PMID: 34659240, PMCID: PMC8517435, DOI: 10.3389/fimmu.2021.744183.Peer-Reviewed Original ResearchConceptsChikungunya virus infectionCHIKV infectionHealthy controlsIL-12IL-1βVirus infectionFlow cytometric bead arrayAcute phase immune responseAcute CHIKV infectionAnti-CHIKV IgMAcute-phase samplesCytometric bead arrayAcute febrile diseaseAcute-phase levelsCHIKV patientsSerum chemokinesCXCL10 levelsPain persistenceIL-10Cytokine kineticsMultivariable analysisCXCL8 levelsIL-6Female sexIL-2Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors
Rodart I, Pares M, Mendes A, Accardo C, Martins J, Silva C, Carvalho F, Barreto J, Reis M, Tersariol I, Nader H. Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors. Molecules 2021, 26: 3892. PMID: 34202190, PMCID: PMC8270308, DOI: 10.3390/molecules26133892.Peer-Reviewed Original ResearchConceptsHepatitis C virusAsymptomatic blood donorsLiver fibrosisBlood donorsSerum hyaluronanHCV infectionSerum levelsGGT serum levelsHA serum levelsHCV RNA detectionHCV viral loadProgressive liver diseaseAdvanced liver fibrosisHigher ALT levelsSignificant liver fibrosisNormal ALTHCV viremiaALT levelsAntiviral treatmentAsymptomatic personsBiopsy confirmationHCV samplesLiver biomarkersLiver diseaseViral loadRisk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
Silva M, Kikuti M, Anjos R, Portilho M, Santos V, Gonçalves T, Tauro L, Moreira P, Jacob-Nascimento L, Santana P, Campos G, Siqueira A, Kitron U, Reis M, Ribeiro G. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal Of Infectious Diseases 2021, 105: 608-616. PMID: 33684559, DOI: 10.1016/j.ijid.2021.03.003.Peer-Reviewed Original ResearchConceptsChronic arthralgiaChikungunya virus infectionRisk factorsVirus infectionDaily activitiesAcute febrile illnessIndependent risk factorPersistence of painCohort of patientsImpact of painProgression of diseaseTranscriptase-polymerase chain reactionPersistent arthralgiaFebrile illnessSubstantial disabilityViral loadFemale sexPolymerase chain reactionIgM enzymeArthralgiaSurveillance studyChikungunya virusDengue virusPatientsImmunosorbent assay
2020
Outbreak of Stenotrophomonas maltophilia and Burkholderia cepacia Bloodstream Infections at a Hemodialysis Center.
Diniz Rocha V, Cavalcanti T, Azevedo J, Leal H, Oliveira Silva G, Xavier Malheiros A, Ataide L, Lima Filho J, Pinto Almeida A, de Andrade Khouri N, Reis M, Neves Reis J. Outbreak of Stenotrophomonas maltophilia and Burkholderia cepacia Bloodstream Infections at a Hemodialysis Center. American Journal Of Tropical Medicine And Hygiene 2020, 104: 848-853. PMID: 33319730, PMCID: PMC7941797, DOI: 10.4269/ajtmh.20-1035.Peer-Reviewed Original ResearchInfluence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC
Hacker KP, Sacramento GA, Cruz JS, de Oliveira D, Nery N, Lindow JC, Carvalho M, Hagan J, Diggle PJ, Begon M, Reis MG, Wunder EA, Ko AI, Costa F. Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 311-314. PMID: 31961288, PMCID: PMC6986844, DOI: 10.3201/eid2602.190102.Peer-Reviewed Original Research
2019
Evaluation of two commercially available chikungunya virus IgM enzyme-linked immunoassays (ELISA) in a setting of concomitant transmission of chikungunya, dengue and Zika viruses
Kikuti M, Tauro L, Moreira P, Nascimento L, Portilho M, Soares G, Weaver S, Reis M, Kitron U, Ribeiro G. Evaluation of two commercially available chikungunya virus IgM enzyme-linked immunoassays (ELISA) in a setting of concomitant transmission of chikungunya, dengue and Zika viruses. International Journal Of Infectious Diseases 2019, 91: 38-43. PMID: 31704226, DOI: 10.1016/j.ijid.2019.11.001.Peer-Reviewed Original ResearchConceptsConvalescent samplesIgM enzymeRT-PCRZika virus transmissionNegative patientsCHIKV infectionAcute samplesZIKV casesConvalescent seraSurveillance studyCHIKV transmissionZika virusCHIKV casesDiagnostic performanceLow specificityVirus transmissionEquivocal resultsTest sensitivitySerumELISA specificityPatientsHigh rateDengueConcomitant transmissionMore equivocal resultsBloodstream infections caused by multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological features
Leal H, Azevedo J, Silva G, Amorim A, de Roma L, Arraes A, Gouveia E, Reis M, Mendes A, de Oliveira Silva M, Barberino M, Martins I, Reis J. Bloodstream infections caused by multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological features. BMC Infectious Diseases 2019, 19: 609. PMID: 31296179, PMCID: PMC6624930, DOI: 10.1186/s12879-019-4265-z.Peer-Reviewed Original ResearchConceptsK. pneumoniaePrevious antimicrobial useLaboratory-based surveillanceAntimicrobial susceptibility testingMDR bacteremiaMDR-GNBDrug-resistant pathogensNegative bacteremiaLiver diseaseBloodstream infectionsHigh morbidityMale sexRisk factorsEpidemiological aspectsNegative bacilliHealthcare professionalsMicrobiological featuresSusceptibility testingBacteremiaInfectionAntimicrobial useCausative agentAntibiotic resistanceIntervention measuresResistance determinantsAccuracy of the SD BIOLINE Dengue Duo for rapid point-of-care diagnosis of dengue
Kikuti M, Cruz J, Rodrigues M, Tavares A, Paploski I, Silva M, Santana P, Tauro L, Silva G, Campos G, Araújo J, Kitron U, Reis M, Ribeiro G. Accuracy of the SD BIOLINE Dengue Duo for rapid point-of-care diagnosis of dengue. PLOS ONE 2019, 14: e0213301. PMID: 30840708, PMCID: PMC6402663, DOI: 10.1371/journal.pone.0213301.Peer-Reviewed Original ResearchConceptsRapid diagnosis testsNon-dengue febrile patientsFebrile patientsHealthy controlsBlood donorsLaboratory-confirmed dengue casesSD BIOLINE Dengue DuoSecondary DENV infectionDengue virus antigenAcute-phase seraDengue diagnostic testsRepresentative serum samplesDengue-endemic regionsDengue-endemic areasSample of casesDENV antibodiesDENV infectionNS1 ELISAPrimary infectionDengue diagnosisMedical treatment decisionsTreatment decisionsVirus antigenRDT accuracyRDT sensitivityA localized outbreak of Chikungunya virus in Salvador, Bahia, Brazil
Tauro L, Cardoso C, Souza R, Nascimento L, dos Santos D, Campos G, Sardi S, dos Reis O, Reis M, Kitron U, Ribeiro G. A localized outbreak of Chikungunya virus in Salvador, Bahia, Brazil. Memórias Do Instituto Oswaldo Cruz 2019, 114: e180597. PMID: 30843962, PMCID: PMC6396974, DOI: 10.1590/0074-02760180597.Peer-Reviewed Original Research
2016
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil
Azevedo J, Dos Anjos ES, Cordeiro S, Dos Santos M, Escobar E, Lobo P, Carvalho MD, Reis M, Reis J, Campos L. Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil. Journal Of Medical Microbiology 2016, 65: 1164-1170. PMID: 27599851, DOI: 10.1099/jmm.0.000346.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBrazilChildChild, PreschoolDrug Resistance, BacterialElectrophoresis, Gel, Pulsed-FieldFemaleGenetic VariationGenotypeHospitalsHumansInfantMaleMeningitis, PneumococcalMicrobial Sensitivity TestsMiddle AgedMolecular EpidemiologyMultilocus Sequence TypingMultiplex Polymerase Chain ReactionPneumococcal VaccinesSerogroupSerotypingStreptococcus pneumoniaeYoung AdultConceptsPost-vaccine periodMulti-locus sequence typing resultsIntroduction of PCV10Non-vaccine serotypesCases of meningitisPneumococcal conjugate vaccineBenefits of vaccinationChildhood vaccination programsAntimicrobial susceptibility testingMulti-locus sequence typingPCV10 introductionPneumococcal meningitisConjugate vaccineReference hospitalSerotype 19AMeningitis casesSerotype 12FVaccination programMore antibioticsSerotype isolatesQuellung reactionE-testStreptococcus pneumoniaeMeningitisSusceptibility testing
2014
Anti-PR3 and anti-MPO antibodies are not present in sera of patients with pulmonary tuberculosis
Lima I, Oliveira R, Cabral M, Atta A, Marchi S, Reis E, Reis M, Barbosa L, Santiago M. Anti-PR3 and anti-MPO antibodies are not present in sera of patients with pulmonary tuberculosis. Rheumatology International 2014, 34: 1231-1234. PMID: 24719228, DOI: 10.1007/s00296-014-3009-z.Peer-Reviewed Original ResearchConceptsAnti-neutrophil cytoplasmic antibodiesAnti-PR3 antibodiesIndirect immunofluorescencePresence of ANCAPrevalence of ANCAInfectious diseasesComponents of neutrophilsGroup of patientsAnti-MPO antibodiesSera of patientsChest X-rayAnti-PR3Cytoplasmic antibodiesVasculitic syndromesTB patientsPulmonary tuberculosisAutoimmune disordersPresent studyClinical similaritiesSuch antibodiesPatientsELISA kitTuberculosisAntibodiesAutoantibodies
2013
Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil
Coelho-Souza T, Reis J, Martins N, Martins I, Menezes A, Reis M, Silva N, Dias R, Riley L, Moreira B. Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil. Clinical Microbiology And Infection 2013, 19: e241-e244. PMID: 23398654, PMCID: PMC3625502, DOI: 10.1111/1469-0691.12145.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAcinetobacter InfectionsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBrazilCarbapenemsChildChild, PreschoolColistinDrug Resistance, Multiple, BacterialEpidemiological MonitoringFemaleHumansMaleMeningitis, BacterialMiddle AgedMolecular EpidemiologyMultilocus Sequence TypingUrban PopulationYoung AdultConceptsMultilocus sequence typingA. baumanniiCarbapenem resistanceClonal complexesDissemination of infectionLongitudinal surveillanceAcinetobacter baumanniiLarge urban settingMeningitisStudy aimBaumanniiSequence typingUrban settingsAntimicrobial agentsSurveillance systemSurveillanceColistinInfectionSetting
2011
TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia
Cajado C, Cerqueira B, Couto F, Moura-Neto J, Vilas-Boas W, Dorea M, Lyra I, Barbosa C, Reis M, Goncalves M. TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia. Cytokine 2011, 56: 312-317. PMID: 21802960, DOI: 10.1016/j.cyto.2011.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesAnemia, Sickle CellBiomarkersCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayHaplotypesHumansInterleukin-8Medical History TakingPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthTumor Necrosis Factor-alphaConceptsSickle cell anemiaTNF-alpha -308GT gene polymorphismGene polymorphismsIL-8Serum levelsMedical historyTNF-alphaCell anemiaHigher TNF-alpha levelsIL-8 gene polymorphismsA alleleClassical biomarkersSteady-state sickle cell anemiaTNF-alpha levelsHeterogeneous clinical outcomesLogistic regression analysisYears of ageCytokine levelsClinical outcomesImmunological biomarkersHealthy controlsPatient outcomesInterleukin-8SCA patients
2010
Evaluating glutathione S‐Transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia
GONCALVES M, NETO J, SOUZA C, MELO P, REIS M. Evaluating glutathione S‐Transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. International Journal Of Laboratory Hematology 2010, 32: e49-e56. PMID: 19555437, DOI: 10.1111/j.1751-553x.2009.01169.x.Peer-Reviewed Original ResearchConceptsGSTM1 null genotypeNull genotypeBiomarkers of susceptibilityWhite blood cell countGlutathione S-transferase null genotypeOccurrence of leukopeniaRisk of neutropeniaBlood cell countCase-control studyWhite blood cell deficiencyGlutathione S-transferaseGSTT1 null genotypeOxidative stress productsBlood cell deficiencyGSTM1 genotypeLeukopeniaNormal subjectsCell countPotential biomarkersNeutropeniaGSTT1BiomarkersStress productsRiskSubjects
2009
Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
Machado A, Finkmoore B, Emodi K, Takenami I, Barbosa T, Tavares M, Reis M, Arruda S, Riley L. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil. The International Journal Of Tuberculosis And Lung Disease 2009, 13: 719-25. PMID: 19460247.Peer-Reviewed Original ResearchConceptsHousehold contactsLatent tuberculosis infectionLTBI treatmentLatent tuberculosis infection treatmentTB-endemic countriesRisks of treatmentHigh-risk populationPulmonary TBMedication intoleranceTuberculosis infectionTuberculosis controlRisk factorsHigh riskSide effectsInfection treatmentHospitalVisitsMonthsTreatmentFollowINHRiskTBRegimenPatients