2020
MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression.
Han R, Zhao J, Lu L. MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression. Oncology Reports 2020, 43: 2062-2072. PMID: 32186770, DOI: 10.3892/or.2020.7549.Peer-Reviewed Original ResearchConceptsBreast cancerNormal breast tissueMDA-MB-231 cellsPatient survivalT-47DKaplan-Meier survival curvesBreast tissueCancer-associated mortalityLonger survival timeCommon cancer typesExpression levelsReverse transcription-quantitative PCRPotential therapeutic toolBreast cancer invasionMicroRNA-34a expressionTranscription-quantitative PCRTumor cell proliferationOverall survivalUnderlying molecular mechanismsCaspase-3 activityDownregulation of E2F1Clinical managementExpression of E2F1Survival timeClinical relevance
2019
MicroRNA-34a suppresses aggressiveness of hepatocellular carcinoma by modulating E2F1, E2F3, and Caspase-3
Han R, Chen X, Li Y, Zhang S, Li R, Lu L. MicroRNA-34a suppresses aggressiveness of hepatocellular carcinoma by modulating E2F1, E2F3, and Caspase-3. Cancer Management And Research 2019, 11: 2963-2976. PMID: 31114344, PMCID: PMC6489561, DOI: 10.2147/cmar.s202664.Peer-Reviewed Original ResearchPrimary hepatocellular carcinomaHepatocellular carcinomaKaplan-Meier survival curvesNormal tissuesSNU-449Cell proliferationLiver cancer cellsQuantitative reverse transcription PCROverall survivalPatient survivalCaspase-3 activityHCC patientsReverse transcription-PCRAntineoplastic roleBetter survivalTreatment groupsTumor aggressivenessRT-qPCR resultsSurvival analysisSurvival curvesMeta-AnalysisCASP3 activityMicroRNA-34aCancer cellsCell invasion