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Henry Yaggi, MD, MPH

Professor of Internal Medicine (Pulmonary, Critical Care & Sleep Medicine); Vice Chief of Research, Pulmonary, Critical Care & Sleep Medicine; Director, Yale Centers for Sleep Medicine, Pulmonary, Critical Care & Sleep Medicine

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The Anlyan Center
300 Cedar Street, Rm S-425A
New Haven, CT 06519

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Pulmonary, Critical Care & Sleep Medicine
PO Box 208057, 300 Cedar Street
New Haven, CT 06520-8057
United States

Yale Sleep Medicine Program

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Research Summary

Dr. Yaggi is an Associate Professor of Medicine at the Yale University School of Medicine and Director of the Yale Program in Sleep Medicine. He is board certified in Internal Medicine, Pulmonary Medicine, Critical Care, and Sleep Medicine. He is a Principal Investigator at the national VA Clinical Epidemiology Research Center. His research interest is the clinical epidemiology of sleep-disordered breathing, with a focus on the diverse health implications of sleep apnea and an emphasis on informing clinical care. Within this larger domain, his work has focused on 3 specific topics: sleep apnea as a risk factor for adverse cardiovascular and metabolic health outcomes; prognostic factors for adverse cardiovascular and metabolic health outcomes in patients with sleep-disordered breathing; and the impact of diagnosing and treating sleep apnea (using home-based strategies) on cardiovascular risk.

Extensive Research Description

Principal Investigator at the national VA Clinical Epidemiology Research Center. His research interest is the clinical epidemiology of sleep-disordered breathing, with a focus on the diverse health implications of sleep apnea and an emphasis on informing clinical care. Within this larger domain, his work has focused on 3 specific topics: sleep apnea as a risk factor for adverse cardiovascular and metabolic health outcomes; prognostic factors for adverse cardiovascular and metabolic health outcomes in patients with sleep-disordered breathing; and the impact of diagnosing and treating sleep apnea (using home-based strategies) on cardiovascular risk.

Agency: VA Clinical Science Research and Develop I.D.# Merit Review Award Title: “Oxygen versus PAP for treatment of sleep apnea in chronic heart failure” P.I.: Yaggi/Gottlieb Role: Principal Investigator Percent effort: 35% Direct costs per year: $250,000 Total costs for project period: $1,500,000 Project period: 10/01/2012 – 09/30/2016

Agency: National institute of Health/National Institute of Nursing Research I.D.# 1P20NR014126-01 Title Yale Center for Sleep Disturbance in Acute and Chronic Conditions P.I. Henry Klar Yaggi, M.D. M.P.H. Percent Effort: 12.5% Direct costs per year: $250,000 Total costs for project period: $1,250,000 Project period: 10/01/2012-9/30/2017

Agency: NIH National Heart Lung and Blood institute (NHLBI) I.D.# U34 HL105285-01 Title: “Sleep Apnea in TIA/ Stroke: Reducing Vascular Risk with CPAP (SLEEP TIGHT)” P.I.: Henry Klar Yaggi, M.D. M.P.H. Percent effort: 30% Direct costs per year: $500,000 Total costs for project period: $2,000,000 Project period: 10/01/2010 – 06/31/2014

Agency: NIH National Heart Lung and Blood institute (NHLBI) I.D.# R21 MD006769 Title: “Multi-Level Modeling of Social Disparities in Sleep and Health” P.I.: Andre Araujo, Ph.D Role: Co-investigator Percent effort: 5% Direct costs per year: $250,000 Total costs for project period: $500,000 Project period: 10/01/2011 – 09/30/2014

Coauthors

Research Interests

Apnea; Arrhythmias, Cardiac; Health Services Administration; Investigative Techniques; Cardiomyopathies; Therapeutics; Health Care

Public Health Interests

Cardiovascular Diseases; Respiratory Disease/Infections

Research Image

pub298w417_594109138-Sleep Apnea

Selected Publications

Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.
Sleep-related predictors of cognition among adults with chronic insomnia and heart failure enrolled in a randomized controlled trial of cognitive behavioral therapy for insomnia.Redeker N, Conley S, O'Connell M, Geer J, Yaggi H, Jeon S. Sleep-related predictors of cognition among adults with chronic insomnia and heart failure enrolled in a randomized controlled trial of cognitive behavioral therapy for insomnia. Journal Of Clinical Sleep Medicine 2023, 19: 1073-1081. PMID: 36740924, PMCID: PMC10235706, DOI: 10.5664/jcsm.10498.
0488 The Relationship between Myocardial Blood Flow and Diastolic Function in a Clinical Population with Obstructive Sleep ApneaAneni E, Saeed G, Thorn S, Miller E, Sinusas A, Yaggi H. 0488 The Relationship between Myocardial Blood Flow and Diastolic Function in a Clinical Population with Obstructive Sleep Apnea. Sleep 2023, 46: a217-a217. DOI: 10.1093/sleep/zsad077.0488.
0726 Agreement Between an Electroencephalography-Measuring Headband and Polysomnography in Older Adults with Sleep DisturbancesMiner B, Pan Y, Burzynski C, Iannone L, Knauert M, Gill T, Yaggi H. 0726 Agreement Between an Electroencephalography-Measuring Headband and Polysomnography in Older Adults with Sleep Disturbances. Sleep 2023, 46: a319-a320. DOI: 10.1093/sleep/zsad077.0726.
0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICULukas M, Doyle M, Intihar T, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU. Sleep 2023, 46: a370-a371. DOI: 10.1093/sleep/zsad077.0841.
0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot studyIntihar T, Doyle M, Lukas M, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study. Sleep 2023, 46: a371-a371. DOI: 10.1093/sleep/zsad077.0842.
0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep ApneaWalker A, Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. 0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea. Sleep 2023, 46: a213-a214. DOI: 10.1093/sleep/zsad077.0480.
0395 Effects of Insomnia and Rest-Activity on Hospitalizations and Emergency Department Visits in People with Stable Heart FailureJeon S, Conley S, Hollenbeak C, O’Connell M, Yaggi H, Jacoby D, Wang Z, Tocchi C, Redeker N. 0395 Effects of Insomnia and Rest-Activity on Hospitalizations and Emergency Department Visits in People with Stable Heart Failure. Sleep 2023, 46: a175-a175. DOI: 10.1093/sleep/zsad077.0395.
0144 A Mixed Methods Exploration of Stigma, Discrimination, and Sleep among Individuals on Medication for Opioid Use DisorderNwanaji-Enwerem U, Sadler L, Jeon S, Barry D, Yaggi H, Redeker N. 0144 A Mixed Methods Exploration of Stigma, Discrimination, and Sleep among Individuals on Medication for Opioid Use Disorder. Sleep 2023, 46: a65-a65. DOI: 10.1093/sleep/zsad077.0144.
0677 Blunted daily light rhythm amplitude in adults with opioid use disorder (OUD)Cox R, Haller S, Martinez-Lisowska Z, Kuppa A, Sprecher K, Withrow D, Barry D, Scheinost D, Redeker N, Yaggi H, Wright K. 0677 Blunted daily light rhythm amplitude in adults with opioid use disorder (OUD). Sleep 2023, 46: a297-a298. DOI: 10.1093/sleep/zsad077.0677.
350. Brain Volume Alterations in Individuals With Opioid Use DisorderMehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Barry D, Redeker N, Yaggi H, Scheinost D. 350. Brain Volume Alterations in Individuals With Opioid Use Disorder. Biological Psychiatry 2023, 93: s235. DOI: 10.1016/j.biopsych.2023.02.590.
Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apneaBaldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.
Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study.Wojeck B, Inzucchi S, Qin L, Yaggi H. Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study. Journal Of Clinical Sleep Medicine 2023, 19: 703-710. PMID: 36689314, PMCID: PMC10071389, DOI: 10.5664/jcsm.10414.
The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow ReserveAneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.
Sleep apnea and strokeGeer J, Karagoz E, Yaggi H. Sleep apnea and stroke. 2023, 271-277. DOI: 10.1016/b978-0-12-822963-7.00325-x.
Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health conditionMiner B, Doyle M, Knauert M, Yaggi H, Stone K, Ancoli‐Israel S, Cauley J, Redline S, Blackwell T, Gill T, Groups F. Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition. Journal Of The American Geriatrics Society 2022, 71: 1198-1208. PMID: 36524599, PMCID: PMC10089942, DOI: 10.1111/jgs.18195.
PreScription DigitaL ThErapEutic For Patients with Insomnia (SLEEP-I): A Protocol for a Pragmatic Randomized Controlled TrialDreyer R, Berkowitz A, Yaggi H, Schneeberg L, Shah N, Emanuel L, Prakash K, Jeffery M, Thorndike F, Deeg M, Ervin K, Ross J. PreScription DigitaL ThErapEutic For Patients with Insomnia (SLEEP-I): A Protocol for a Pragmatic Randomized Controlled Trial. Sleep Medicine 2022, 100: s133-s134. DOI: 10.1016/j.sleep.2022.05.365.
Obstructive Sleep Apnea Severity is Associated with Abnormal Myocardial 82Rubidium PET Blood Flow ReserveAneni E, Chen J, Thorn S, Miller E, Sinusas A, Yaggi H. Obstructive Sleep Apnea Severity is Associated with Abnormal Myocardial 82Rubidium PET Blood Flow Reserve. Sleep Medicine 2022, 100: s261. DOI: 10.1016/j.sleep.2022.05.703.
Ertugliflozin and Incident Obstructive Sleep Apnea: An Analysis from the VERTIS CV TrialWojeck B, Inzucchi S, Neeland I, Mancuso J, Frederich R, Masiukiewicz U, Cater N, McGuire D, Cannon C, Yaggi H. Ertugliflozin and Incident Obstructive Sleep Apnea: An Analysis from the VERTIS CV Trial. Sleep Medicine 2022, 100: s249-s250. DOI: 10.1016/j.sleep.2022.05.671.
Abstract 14839: Clinical, Polysomnographic and Echocardiographic Correlates of Excessive Daytime SleepinessSaeed G, Aneni E, Otite F, Thorn S, Miller E, Sinusas A, Yaggi H. Abstract 14839: Clinical, Polysomnographic and Echocardiographic Correlates of Excessive Daytime Sleepiness. Circulation 2022, 146: a14839-a14839. DOI: 10.1161/circ.146.suppl_1.14839.
Abstract 13798: Obstructive Sleep Apnea Severity and Abnormal Right Ventricular Flow Reserve in Adult OSA Patients Who Received Rubidium-82 Cardiac PET Perfusion ImagingAneni E, Miller E, Saeed G, deKemp R, KLEIN R, Beanlands R, Yaggi H, Sinusas A, Thorn S. Abstract 13798: Obstructive Sleep Apnea Severity and Abnormal Right Ventricular Flow Reserve in Adult OSA Patients Who Received Rubidium-82 Cardiac PET Perfusion Imaging. Circulation 2022, 146: a13798-a13798. DOI: 10.1161/circ.146.suppl_1.13798.
Abstract 10200: Costs and Resource Utilization of People With Stable Heart Failure and Insomnia: Evidence From a Randomized TrialHollenbeak C, Jeong S, O'Connell M, Redeker N, Yaggi H. Abstract 10200: Costs and Resource Utilization of People With Stable Heart Failure and Insomnia: Evidence From a Randomized Trial. Circulation 2022, 146: a10200-a10200. DOI: 10.1161/circ.146.suppl_1.10200.
0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA)Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.
0790 Racial Differences in Self-Efficacy for Positive Airway Pressure Therapy Among Individuals Newly Diagnosed with Obstructive Sleep ApneaByrne S, Sharma A, Deng A, Chu J, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. 0790 Racial Differences in Self-Efficacy for Positive Airway Pressure Therapy Among Individuals Newly Diagnosed with Obstructive Sleep Apnea. Sleep 2022, 45: a343-a343. DOI: 10.1093/sleep/zsac079.786.
0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older PersonsMiner B, Yaggi H, Gill T, Doyle M, Stone K, Redline S, Ensrud K, Blackwell T, Knauert M. 0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older Persons. Sleep 2022, 45: a144-a145. DOI: 10.1093/sleep/zsac079.319.
Self-reported and actigraphic short sleep duration in older adults.Miner B, Stone KL, Zeitzer JM, Han L, Doyle M, Blackwell T, Gill TM, Redeker NS, Hajduk A, Yaggi H. Self-reported and actigraphic short sleep duration in older adults. Journal Of Clinical Sleep Medicine 2022, 18: 403-413. PMID: 34338629, PMCID: PMC8804982, DOI: 10.5664/jcsm.9584.
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.
Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 DiabetesDing Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.
441 Influence Of Chronotype On CPAP AdherenceAdekolu O, Xu Z, Chu J, Kushida C, Yaggi H, Knauert M, Zinchuk A. 441 Influence Of Chronotype On CPAP Adherence. Sleep 2021, 44: a174-a175. DOI: 10.1093/sleep/zsab072.440.
Prevalence of Obstructive Sleep Apnea in a Cohort of Veterans with Chronic Pain and Active Smoking HistoryKunitomo Y, Lee M, DeRycke E, Yaggi H, Bastian L. Prevalence of Obstructive Sleep Apnea in a Cohort of Veterans with Chronic Pain and Active Smoking History. 2021, a1564-a1564. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1564.
342 CBT-I Has Sustained Effects on Insomnia Versus Heart-Failure Self-Management Education among Adults with Chronic Heart FailureRedeker N, Bessette A, Breazeale S, Conley S, Hollenbeak C, Hwang Y, Iannacco J, Jacoby D, Kelly-Hauser J, Linsky S, Moemeka L, Nwanaji-Enwerem U, O’Connell M, Yaggi H, Jeon S. 342 CBT-I Has Sustained Effects on Insomnia Versus Heart-Failure Self-Management Education among Adults with Chronic Heart Failure. Sleep 2021, 44: a136-a137. DOI: 10.1093/sleep/zsab072.341.
Treatment-Emergent Central Sleep ApneaZinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea. 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.
Abstract 14962: Empagliflozin’s Cardiovascular Impact in High-Risk Patients With Type 2 Diabetes and Obstructive Pulmonary Disease: An Inquiry From EMPA-REG OUTCOMEAnker S, Fitchett D, Zinman B, Ofstad A, Wanner C, Vedin O, Schinzel B, Yaggi H, George J, Sander L, Inzucchi S, Verma S. Abstract 14962: Empagliflozin’s Cardiovascular Impact in High-Risk Patients With Type 2 Diabetes and Obstructive Pulmonary Disease: An Inquiry From EMPA-REG OUTCOME. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.14962.
Obstructive sleep apnoe and cardiovascular, heart failure and mortality outcomes with empagliflozin versus placebo in the EMPA-REG OUTCOME trialYaggi H, Eliasson B, Kasai T, Marx N, Zinman B, Inzucchi S, Wanner C, Zwiener I, Wojeck B, Neeland I, Johansen O. Obstructive sleep apnoe and cardiovascular, heart failure and mortality outcomes with empagliflozin versus placebo in the EMPA-REG OUTCOME trial. European Heart Journal 2020, 41 DOI: 10.1093/ehjci/ehaa946.2883.
1128-P: Empagliflozin and Obstructive Sleep Apnea (OSA): Exploratory Analysis from the EMPA-REG OUTCOME TrialNEELAND I, ELIASSON B, KASAI T, MARX N, ZINMAN B, INZUCCHI S, WANNER C, ZWIENER I, WOJECK B, YAGGI H, JOHANSEN O. 1128-P: Empagliflozin and Obstructive Sleep Apnea (OSA): Exploratory Analysis from the EMPA-REG OUTCOME Trial. Diabetes 2020, 69 DOI: 10.2337/db20-1128-p.
0852 Geriatric Health Conditions And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep DurationMiner B, Fragoso C, Han L, Yaggi H, Redeker N, Stone K. 0852 Geriatric Health Conditions And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep Duration. Sleep 2020, 43: a324-a325. DOI: 10.1093/sleep/zsaa056.848.
0855 Primary Sleep Disorders And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep Duration In Older PersonsMiner B, Fragoso C, Han L, Stone K, Redeker N, Yaggi H. 0855 Primary Sleep Disorders And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep Duration In Older Persons. Sleep 2020, 43: a325-a326. DOI: 10.1093/sleep/zsaa056.851.
0568 Physiologic OSA Traits and CPAP Adherence Among Patients with Coronary Artery Disease and OSAZinchuk A, Yaggi H, Liang J, Chu J, De Beeck S, Stepnowski C, Wellman A, Peker Y, Sands S. 0568 Physiologic OSA Traits and CPAP Adherence Among Patients with Coronary Artery Disease and OSA. Sleep 2020, 43: a218-a218. DOI: 10.1093/sleep/zsaa056.565.
Maximal Airflow Increase Rate (MAFIR): A New Metric of Arousal Threshold and a Cause of Respiratory ArousalLiu J, Yaggi H. Maximal Airflow Increase Rate (MAFIR): A New Metric of Arousal Threshold and a Cause of Respiratory Arousal. 2020, a6455-a6455. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6455.
Obstructive Sleep Apnea: A Prevalent and Novel Risk Factor for Intracerebral HemorrhageGeer J, Vanent K, Leasure A, Pisani M, Sansing L, Woo D, Langefeld C, Falcone G, Sheth K, Yaggi H. Obstructive Sleep Apnea: A Prevalent and Novel Risk Factor for Intracerebral Hemorrhage. 2020, a2713-a2713. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2713.
Obstructive Sleep Apnoe and Cardiovascular, Heart Failure and Mortality Outcomes with Empagliflozin Versus Placebo in the EMPA-REG Outcome ® TrialYaggi H, Eliasson B, Kasai T, Marx N, Zinman B, Inzucchi S, Wanner C, Zwiener I, Wojeck B, Neeland I, Johansen O. Obstructive Sleep Apnoe and Cardiovascular, Heart Failure and Mortality Outcomes with Empagliflozin Versus Placebo in the EMPA-REG Outcome ® Trial. 2020, a4713-a4713. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4713.
Physiologic Traits Predict Therapeutic Pressure Requirements and Residual Respiratory Events Among Patients with Coronary Artery Disease and Obstructive Sleep ApneaZinchuk A, Yaggi H, Liang J, Chu J, Op de Beeck S, Stepnowsky C, Wellman D, Peker Y, Sands S. Physiologic Traits Predict Therapeutic Pressure Requirements and Residual Respiratory Events Among Patients with Coronary Artery Disease and Obstructive Sleep Apnea. 2020, a6439-a6439. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6439.
Abstract TP347: Obstructive Sleep Apnea Frequency in Intracerebral HemorrhageGeer J, Leasure A, Vanent K, Sansing L, Woo D, Langefeld C, Yaggi H, Falcone G, Sheth K. Abstract TP347: Obstructive Sleep Apnea Frequency in Intracerebral Hemorrhage. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.tp347.
Low Arousal Threshold Correlates with Reduced Continuous Positive Airway Pressure Use in Non-Obese Individuals with Obstructive Sleep Apnea and StrokeZinchuk A, Yaggi H, Concato J, Jeon S, Bravata D, Wellman D, Sands S. Low Arousal Threshold Correlates with Reduced Continuous Positive Airway Pressure Use in Non-Obese Individuals with Obstructive Sleep Apnea and Stroke. 2019, a2598-a2598. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2598.
Effect of Arousal Scoring on Reliability of Automated, Non-Invasive Phenotyping of Physiologic Sleep Apnea Traits from PolysomnographyZinchuk A, Yaggi H, Concato J, Wellman D, Smales E, Hess L, Denos J, Peker Y, Sands S. Effect of Arousal Scoring on Reliability of Automated, Non-Invasive Phenotyping of Physiologic Sleep Apnea Traits from Polysomnography. 2019, a7078-a7078. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7078.
0138 Physiological Effects of Respiratory Events that Terminate Without Arousals During SleepLiu J, Qin L, Yaggi H. 0138 Physiological Effects of Respiratory Events that Terminate Without Arousals During Sleep. Sleep 2019, 42: a56-a57. DOI: 10.1093/sleep/zsz067.137.
0494 Associations of Obstructive Sleep Apnea with Renal Function Decline in a Cohort of VeteransLiu J, Qin L, McConaughey C, Yaggi H. 0494 Associations of Obstructive Sleep Apnea with Renal Function Decline in a Cohort of Veterans. Sleep 2019, 42: a198-a198. DOI: 10.1093/sleep/zsz067.492.
0709 Self-Reported and Actigraphic Short Sleep Duration in Older PersonsMiner B, MHS M, Stone K, Hajduk A, Yaggi H, Redeker N, Fragoso C. 0709 Self-Reported and Actigraphic Short Sleep Duration in Older Persons. Sleep 2019, 42: a284-a285. DOI: 10.1093/sleep/zsz067.707.
Characterization of Arousals in Polysomnography Using the Statistical Significance of Power ChangeLiu J, Yaggi H. Characterization of Arousals in Polysomnography Using the Statistical Significance of Power Change. 2018, 00: 1-6. DOI: 10.1109/spmb.2018.8615603.
0466 High Frequency Of PLMS Is Associated With Increased Risk Of Incident Adverse Cardiovascular Events And Death Among OSA PatientsZinchuk A, Jeon S, Yaggi H. 0466 High Frequency Of PLMS Is Associated With Increased Risk Of Incident Adverse Cardiovascular Events And Death Among OSA Patients. Sleep 2018, 41: a176-a176. DOI: 10.1093/sleep/zsy061.465.
0943 Dream Enactment Behavior in Post Traumatic Stress Disorder PatientsWilliams C, Yaggi H, Kuna S, Asare V. 0943 Dream Enactment Behavior in Post Traumatic Stress Disorder Patients. Sleep 2018, 41: a350-a350. DOI: 10.1093/sleep/zsy061.942.
0881 Insomnia Is Related To Self-care In People With Stable Heart FailureConley S, Jeon S, Yaggi H, Jacoby D, Hollenbeak C, O’Connell M, Linsky S, Darden J, Gaiser E, Kelly-Hauser J, Matthew B, Richardson P, Redeker N. 0881 Insomnia Is Related To Self-care In People With Stable Heart Failure. Sleep 2018, 41: a327-a328. DOI: 10.1093/sleep/zsy061.880.
0574 A Composite Model of Commonly Derived Polysomnographic Variables Predicts Risk of Cardiovascular Outcomes Better than the Apnea Hypopnea Index AloneTrivedi V, Zinchuk A, Qin L, Bravata D, Strohl K, Selim B, Yaggi H. 0574 A Composite Model of Commonly Derived Polysomnographic Variables Predicts Risk of Cardiovascular Outcomes Better than the Apnea Hypopnea Index Alone. Sleep 2018, 41: a213-a214. DOI: 10.1093/sleep/zsy061.573.
0734 Subjective-Objective Sleep Discrepancy in Older AdultsMiner B, Hajduk A, Yaggi H, Fragoso C. 0734 Subjective-Objective Sleep Discrepancy in Older Adults. Sleep 2018, 41: a272-a273. DOI: 10.1093/sleep/zsy061.733.
0755 LONGITUDINAL ASSOCIATIONS OF RISK FACTORS WITH INSOMNIA SEVERITY IN OLDER PERSONSMiner B, Redeker N, Yaggi H, Van Ness P, Han L, Gill T, Fragoso C. 0755 LONGITUDINAL ASSOCIATIONS OF RISK FACTORS WITH INSOMNIA SEVERITY IN OLDER PERSONS. Sleep 2017, 40: a280-a280. DOI: 10.1093/sleepj/zsx050.754.
Sleep Disturbance Among HIV-Infected and Uninfected VeteransWomack JA, Murphy TE, Bathulapalli H, Akgün KM, Gibert C, Kunisaki KM, Rimland D, Rodriguez-Barradas M, Yaggi H, Justice AC, Redeker NS. Sleep Disturbance Among HIV-Infected and Uninfected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: e117-e120. PMID: 27906767, PMCID: PMC5326673, DOI: 10.1097/qai.0000000000001264.
Cognitive behavioral therapy for insomnia in stable heart failure: Protocol for a randomized controlled trialRedeker NS, Knies AK, Hollenbeak C, Yaggi H, Cline J, Andrews L, Jacoby D, Sullivan A, O'Connell M, Iennaco J, Finoia L, Jeon S. Cognitive behavioral therapy for insomnia in stable heart failure: Protocol for a randomized controlled trial. Contemporary Clinical Trials 2017, 55: 16-23. PMID: 28159703, PMCID: PMC5348292, DOI: 10.1016/j.cct.2017.01.009.
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methodsKoo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
Abstract W P167: Obstructive Sleep Apnea in Wake-Up StrokeKoo B, Yaggi H, Qin L, Tobias L, Bravata D. Abstract W P167: Obstructive Sleep Apnea in Wake-Up Stroke. Stroke 2015, 46 DOI: 10.1161/str.46.suppl_1.wp167.
The Association of Opioid Use, Sleep-Disordered Breathing, and Mortality in the DREAM StudySharifi H, Sands M, Bernardo S, Strohl K, Ferguson J, Jimenez W, Qin L, Bennett A, Doctor K, Struve F, Bravata D, Yaggi H. The Association of Opioid Use, Sleep-Disordered Breathing, and Mortality in the DREAM Study. CHEST Journal 2014, 146: 959a. DOI: 10.1378/chest.1988052.
OSA and HIV infectionKunisaki K, Akgün K, Fiellin D, Gibert C, Kim J, Rimland D, Rodriguez‐Barradas M, Yaggi H, Crothers K. OSA and HIV infection. HIV Medicine 2014, 16: 105-113. PMID: 25230851, PMCID: PMC4300288, DOI: 10.1111/hiv.12182.
Abstract W P128: Development and Validation of Clinical Prediction Model for Obstructive Sleep Apnea among Patients with Ischemic Stroke and TIASico J, Ofner S, Qin L, Yaggi H, Bravata D. Abstract W P128: Development and Validation of Clinical Prediction Model for Obstructive Sleep Apnea among Patients with Ischemic Stroke and TIA. Stroke 2014, 45 DOI: 10.1161/str.45.suppl_1.wp128.
Effects of Obstructive Sleep Apnea Therapy on Cardiovascular DiseaseShah N, Kizer J, Yaggi H. Effects of Obstructive Sleep Apnea Therapy on Cardiovascular Disease. Sleep Medicine Clinics 2013, 8: 453-461. DOI: 10.1016/j.jsmc.2013.07.015.
Sex-related Differences in Cardiometabolic Outcomes Associated With Obstructive Sleep ApneaShah N, Yaggi H, Redline S. Sex-related Differences in Cardiometabolic Outcomes Associated With Obstructive Sleep Apnea. Clinical Pulmonary Medicine 2013, 20: 149-154. DOI: 10.1097/cpm.0b013e31828fce1b.
Abstract WP189: Prediction of Apnea Hypopnea Index among Stroke and TIA PatientsSico J, Ofner S, Yaggi H, Bravata D. Abstract WP189: Prediction of Apnea Hypopnea Index among Stroke and TIA Patients. Stroke 2013, 44 DOI: 10.1161/str.44.suppl_1.awp189.
Abstract WP445: Age Differences in the Impact of Sleep Apnea on Cognition and Quality of LifeAddison-Brown K, Letter A, Yaggi H, McClure L, Unverzagt F, Howard V, Lichtman J, Wadley V. Abstract WP445: Age Differences in the Impact of Sleep Apnea on Cognition and Quality of Life. Stroke 2013, 44 DOI: 10.1161/str.44.suppl_1.awp445.
Abstract TP318: The Circumstances and Consequences of Post-stroke FallsSchmid A, Yaggi H, Burrus N, McClain V, Austin C, Ferguson J, Fragoso C, Sico J, Ofner S, Miech E, Matthias M, Williams L, Bravata D. Abstract TP318: The Circumstances and Consequences of Post-stroke Falls. Stroke 2013, 44 DOI: 10.1161/str.44.suppl_1.atp318.
Erratum to: Obstructive sleep apnea and acute myocardial infarction severity: ischemic preconditioning?Shah N, Redline S, Yaggi H, Wu R, Zhao C, Ostfeld R, Menegus M, Tracy D, Brush E, Appel W, Kaplan R. Erratum to: Obstructive sleep apnea and acute myocardial infarction severity: ischemic preconditioning? Sleep And Breathing 2012, 17: 1119-1119. DOI: 10.1007/s11325-012-0793-0.
Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care UnitKnauert M, Yaggi H, Redeker N, Murphy T, Araujo K, Pisani M. Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care Unit. CHEST Journal 2012, 142: 547a-547b. DOI: 10.1378/chest.1383037.
Response to ambulatory blood pressure monitoring in acute strokeBravata D, Sico J, Phipps M, Yaggi H. Response to ambulatory blood pressure monitoring in acute stroke. Blood Pressure Monitoring 2012, 17: 221-222. DOI: 10.1097/mbp.0b013e328358d95a.
Investigating the Healthy User Effect: Correlating CPAP Use and Medication AdherenceDieffenbach P, Bravata D, Ferguson J, McClain V, Austin C, Struve F, Li X, Williams L, Sico J, Fragoso C, Burrus N, Concato J, Kim N, Yaggi H. Investigating the Healthy User Effect: Correlating CPAP Use and Medication Adherence. CHEST Journal 2012, 142: 1053a-1053c. DOI: 10.1378/chest.1386770.
Response to the Letter to the Editor from Parra and ArboixBravata D, Yaggi H. Response to the Letter to the Editor from Parra and Arboix. Sleep 2012, 35: 749-749. PMCID: PMC3353050, DOI: 10.5665/sleep.1862.
Feasibility Of Conducting 24-Hour Polysomnography Studies In The Medical Intensive Care UnitKnauert-Brown M, Yaggi H, Redeker N, Murphy T, Araujo K, Donlon T, Pisani M. Feasibility Of Conducting 24-Hour Polysomnography Studies In The Medical Intensive Care Unit. 2012, a1617-a1617. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1617.
Chapter 51 Sleep-Disordered Breathing and Cerebrovascular DiseaseYaggi H, Dieffenbach P. Chapter 51 Sleep-Disordered Breathing and Cerebrovascular Disease. 2012, 647-655. DOI: 10.1016/b978-1-4377-1703-7.10051-9.
Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged PersonsFragoso C, Gill TM, McAvay G, Van Ness PH, Yaggi HK, Concato J. Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged Persons. Respiratory Care 2011, 56: 1771-1777. PMID: 21605489, PMCID: PMC3676885, DOI: 10.4187/respcare.01192.
Sleep Apnea and Cerebrovascular DisordersYaggi H. Sleep Apnea and Cerebrovascular Disorders. 2011, 302-310. DOI: 10.2174/978160805153311101010302.
The Role of Obstructive Sleep Apnea in Type 2 DiabetesDieffenbach P, Yaggi H. The Role of Obstructive Sleep Apnea in Type 2 Diabetes. International Journal Of Clinical Reviews 2011 DOI: 10.5275/ijcr.2011.07.03.
Obstructive Sleep Apnea And Severity Of Acute Myocardial Infarction: Ischemic Preconditioning?Shah N, Appel D, Kaplan R, Yaggi H. Obstructive Sleep Apnea And Severity Of Acute Myocardial Infarction: Ischemic Preconditioning? 2011, a2485-a2485. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2485.
PrefaceYaggi H, Chiong T, Mohsenin V. Preface. Clinics In Chest Medicine 2010, 31: xiii-xiv. DOI: 10.1016/j.ccm.2010.03.003.
Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic AttackBravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight HJ, Lo A, Richerson GB, Gorman M, Williams LS, Brass LM, Agostini J, Mohsenin V, Roux F, Yaggi HK. Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack. Stroke 2010, 41: 1464-1470. PMID: 20508184, PMCID: PMC4567557, DOI: 10.1161/strokeaha.109.566745.
The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary DiseaseVaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM. The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 2009, 181: 446-451. PMID: 20019341, PMCID: PMC3159085, DOI: 10.1164/rccm.200909-1366oc.
Obstructive Sleep Apnea as a Risk Factor for Type 2 DiabetesBotros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes. The American Journal Of Medicine 2009, 122: 1122-1127. PMID: 19958890, PMCID: PMC2799991, DOI: 10.1016/j.amjmed.2009.04.026.
The Diagnosis and Treatment of Sleep Apnea among Patients with Transient Ischemic Attack: Results of a Feasibility Study.Yaggi H, Concato J, Mohsenin V, McClain V, Fried T, Ranjbar N, Sadarangani T, Struve F, Zygmunt L, Lo A, Richerson G, Gorman M, Williams L, Brass L, Agostini J, Roux F, Bravata D. The Diagnosis and Treatment of Sleep Apnea among Patients with Transient Ischemic Attack: Results of a Feasibility Study. 2009, a3989. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3989.
The Diagnosis and Treatment of Sleep Apnea among Patients with Acute Ischemic Stroke: Results of a Feasiblity Study.Yaggi H, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Lo A, Richerson G, Gorman M, Williams L, Brass L, Agostini J, Mohsenin V, Roux F, Bravata D. The Diagnosis and Treatment of Sleep Apnea among Patients with Acute Ischemic Stroke: Results of a Feasiblity Study. 2009, a5338. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5338.
The effect of gender on the prevalence of hypertension in obstructive sleep apneaMohsenin V, Yaggi HK, Shah N, Dziura J. The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Medicine 2009, 10: 759-762. PMID: 19185538, DOI: 10.1016/j.sleep.2008.09.005.
Sleep and the Cardiovascular SystemYaggi H. Sleep and the Cardiovascular System. 2009, 123-132. DOI: 10.1378/smbr.4th.123.
Obstructive Sleep Apnea-Hypopnea Syndrome: Definitions, Epidemiology, and PathogenesisYaggi H. Obstructive Sleep Apnea-Hypopnea Syndrome: Definitions, Epidemiology, and Pathogenesis. 2009, 185-192. DOI: 10.1378/smbr.4th.185.
RACIAL DIFFERENCES IN OBSTRUCTIVE SLEEP APNEA AND RISK OF HYPERTENSIONSands M, Botros N, Lichtman J, Yaggi H. RACIAL DIFFERENCES IN OBSTRUCTIVE SLEEP APNEA AND RISK OF HYPERTENSION. CHEST Journal 2008, 134: s51003-a-s51003-b. DOI: 10.1378/chest.134.4_meetingabstracts.s51003.
DEFINING CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN OLDER PERSONSFragoso C, McAvay G, Van Ness P, Yaggi H, Rochester C, Concato J, Gill T. DEFINING CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN OLDER PERSONS. CHEST Journal 2008, 134: s27003-a-s27003-b. DOI: 10.1378/chest.134.4_meetingabstracts.s27003.
Sleep Apnea and Stroke: A Risk Factor or an Association?Yaggi H, Mohsenin V. Sleep Apnea and Stroke: A Risk Factor or an Association? Sleep Medicine Clinics 2007, 2: 583-591. DOI: 10.1016/j.jsmc.2007.07.004.
ELECTRIC AND MAGNETIC FIELDSYaggi H, Mohsenin V. ELECTRIC AND MAGNETIC FIELDS. 2006, 88-91. DOI: 10.1201/b14948-16.
Obstructive Sleep Apnea as a Risk Factor for Stroke and DeathYaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. New England Journal Of Medicine 2005, 353: 2034-2041. PMID: 16282178, DOI: 10.1056/nejmoa043104.
Sleep Apnea and Cerebrovascular DiseaseMohsenin V, Yaggi H. Sleep Apnea and Cerebrovascular Disease. 2005, 287-292. DOI: 10.1002/0471751723.ch38.
Sleep duration and risk of diabetes in middle-aged and older men: prospective results from the Massachusetts male aging studyAraujo A, Yaggi H, McKinlay J. Sleep duration and risk of diabetes in middle-aged and older men: prospective results from the Massachusetts male aging study. Annals Of Epidemiology 2004, 14: 598. DOI: 10.1016/j.annepidem.2004.07.019.

Clinical Trials

Conditions	Study Title
Immune System; Men's Health; Women's Health	Effects of circadian regulation and sleep on immune responses
Diseases of the Cardiovascular System	The Recovery in Stroke Using PAP Study (RISE-UP)
Diseases of the Cardiovascular System; Diseases of the Nervous System	Sleep for Stroke Management and Recovery Trial (Sleep SMART)

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