2023
TheMarker: a comprehensive database of therapeutic biomarkers
Zhang Y, Zhou Y, Zhou Y, Yu X, Shen X, Hong Y, Zhang Y, Wang S, Mou M, Zhang J, Tao L, Gao J, Qiu Y, Chen Y, Zhu F. TheMarker: a comprehensive database of therapeutic biomarkers. Nucleic Acids Research 2023, 52: d1450-d1464. PMID: 37850638, PMCID: PMC10767989, DOI: 10.1093/nar/gkad862.Peer-Reviewed Original ResearchConceptsClinical practiceTherapeutic biomarkersTherapy-induced toxicityClinical outcomesPredictive biomarkersPharmacodynamic biomarkersClinical managementPrognostic biomarkerSafety biomarkersClinical developmentPatient statusPharmacological effectsMonitoring biomarkerTherapyBiomarkersAnticancer therapyDrug developmentDrug discoveryDisease classesStatusDatabase
2022
Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative review
Shen X, Jain A, Aladelokun O, Yan H, Gilbride A, Ferrucci LM, Lu L, Khan SA, Johnson CH. Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative review. Frontiers In Molecular Biosciences 2022, 9: 958666. PMID: 36090030, PMCID: PMC9453556, DOI: 10.3389/fmolb.2022.958666.Peer-Reviewed Original ResearchColorectal cancerCRC patientsNarrative reviewSex steroid hormone estrogenFemale CRC patientsAnti-tumor effectsPI3K/Akt/Sex-related influencesSex-related factorsAsparagine synthetase expressionSex-specific factorsClinical outcomesTumor burdenCRC progressionPoor prognosisHormone estrogenEstrogen receptorSOX12 expressionRole of sexTherapeutic useAkt/Cancer cellsSynthetase expressionL-asparaginasePatients