2009
Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project
Ding H, Wilson CM, Modjarrad K, McGwin G, Tang J, Vermund SH. Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project. JAMA Pediatrics 2009, 163: 1100-1105. PMID: 19996046, PMCID: PMC3739292, DOI: 10.1001/archpediatrics.2009.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChi-Square DistributionFemaleHIV InfectionsHumansInterviews as TopicLogistic ModelsMalePatient CompliancePredictive Value of TestsPrevalenceProspective StudiesStatistics, NonparametricTreatment OutcomeUnited StatesViral LoadYoung AdultConceptsHuman immunodeficiency virus-infected adolescentsSuboptimal virologic responsePoor virologic responseVirologic responseActive antiretroviral therapyAntiretroviral therapyVirologic suppressionMultivariable logistic regression modelDual antiretroviral therapyInitiation of HAARTSuboptimal antiretroviral therapyAge-specific interventionsAcademic medical centerLogistic regression modelsCohort studyLymphocyte countViral loadEcho findingsAdequate adherenceTherapeutic failureBiopsychosocial predictorsHAARTMedical CenterAdolescent careConsecutive visits
2002
Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents
Tang J, Wilson CM, Meleth S, Myracle A, Lobashevsky E, Mulligan MJ, Douglas SD, Korber B, Vermund SH, Kaslow RA. Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents. AIDS 2002, 16: 2275-2284. PMID: 12441799, DOI: 10.1097/00002030-200211220-00007.Peer-Reviewed Original ResearchConceptsViral loadHLA class IHost genetic profileHIV-1-infected adolescentsHIV-1-seropositive participantsCD4 T-cell countClass IHIV-seronegative individualsT-cell countsCD4 T lymphocytesHIV-1 infectionHIV-1 pathogenesisGenetic profileClinical patient groupsAntiretroviral therapyQuarterly followMultivariable analysisHealth cohortPatient groupImmunological outcomesImmunological controlNegative HLAT lymphocytesProtective effectAdolescent care
2001
Sexually transmitted infections among HIV infected and HIV uninfected high-risk youth in the REACH study
Vermund S, Wilson C, Rogers A, Partlow C, Moscicki A. Sexually transmitted infections among HIV infected and HIV uninfected high-risk youth in the REACH study. Journal Of Adolescent Health 2001, 29: 49-56. PMID: 11530303, DOI: 10.1016/s1054-139x(01)00296-8.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusUninfected youthHigh STI ratesSexual risk profilesBaseline prevalence dataHigher infection rateImmunodeficiency virusREACH studySTI ratesAdolescent careHigh-risk youthInfection ratePrevalence dataRisk profileHealth ProjectCross-sectional dataSpecimen collectionRisk reductionLongitudinal analysisInfectionReviewSTIsBaselineCareLaboratory analysis
2000
Psychological distress among HIV+ adolescents in the REACH study: effects of life stress, social support, and coping
Murphy D, Moscicki A, Vermund S, Muenz L, Network T. Psychological distress among HIV+ adolescents in the REACH study: effects of life stress, social support, and coping. Journal Of Adolescent Health 2000, 27: 391-398. PMID: 11090741, DOI: 10.1016/s1054-139x(00)00158-0.Peer-Reviewed Original ResearchConceptsAdaptive copingSocial supportPsychological distressLife eventsAdaptive coping methodsParental alcohol abuseFamily financial problemsCoping methodsStressful eventsCopingLife stressAdolescent assessmentAnxietyAdolescentsHigh levelsDistressAdolescent careSatisfactionDepressionAlcohol abuseDrug useSexual behaviorREACH studySupportFinancial problemsT-Lymphocyte Subsets in HIV-Infected and High-Risk HIV-Uninfected Adolescents: Retention of Naive T Lymphocytes in HIV-Infected Adolescents
Douglas SD, Rudy B, Muenz L, Starr SE, Campbell DE, Wilson C, Holland C, Crowley-Nowick P, Vermund SH. T-Lymphocyte Subsets in HIV-Infected and High-Risk HIV-Uninfected Adolescents: Retention of Naive T Lymphocytes in HIV-Infected Adolescents. JAMA Pediatrics 2000, 154: 375-380. PMID: 10768676, DOI: 10.1001/archpedi.154.4.375.Peer-Reviewed Original ResearchConceptsHIV-negative youthHuman immunodeficiency virus-infected adolescentsT lymphocyte subsetsNaive CD8Total CD4Immune systemCell countHIV infectionAdolescent careAdolescent Medicine HIV/AIDS Research NetworkHuman immunodeficiency virus (HIV) infectionHealth ProjectActive antiretroviral therapyCohort of HIVPercentage of CD4HIV-negative controlsHIV-positive subjectsImmunodeficiency virus infectionAIDS Research NetworkHigh-risk HIVT lymphocyte responsesHIV-negative adolescentsNaive T lymphocytesMemory cell populationsSignificant increase
1998
The REACH Project of the Adolescent Medicine HIV/AIDS Research Network: Design, Methods, and Selected Characteristics of Participants
Rogers A, Futterman D, Moscicki A, Wilson C, Ellenberg J, Vermund S. The REACH Project of the Adolescent Medicine HIV/AIDS Research Network: Design, Methods, and Selected Characteristics of Participants. Journal Of Adolescent Health 1998, 22: 300-311. PMID: 9561462, DOI: 10.1016/s1054-139x(97)00279-6.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdolescent Health ServicesCohort StudiesComorbidityData CollectionDisease ProgressionFemaleHealth Planning OrganizationsHIV InfectionsHumansMaleMulticenter Studies as TopicProgram DevelopmentProspective StudiesResearchResearch DesignUnited StatesConceptsAdolescent Medicine HIV/AIDS Research NetworkMedical chart abstractionGroup of HIVHIV-negative controlsAIDS Research NetworkHIV-positive youthLocal institutional review boardInstitutional review boardResearch NetworkREACH projectChart abstractionClinical characteristicsImmunologic profileClinical courseHIV pathogenesisPhysical examinationHIV epidemicStudy populationAdolescent careDisease comorbiditiesClinical experienceMultidisciplinary teamHormonal variationsStudy aimReview board