2023
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchMeSH KeywordsAlkanesulfonic AcidsChildEnvironmental ExposureEnvironmental PollutantsFluorocarbonsHumansInfant, NewbornPilot ProjectsThyroid HormonesConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometry
2021
Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum
Jin L, Godri Pollitt KJ, Liew Z, Rosen Vollmar AK, Vasiliou V, Johnson CH, Zhang Y. Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum. Current Environmental Health Reports 2021, 8: 7-22. PMID: 33420964, DOI: 10.1007/s40572-020-00298-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsAir PollutionChildEnvironmental ExposureFemaleHumansMetabolomicsOxidative StressParticulate MatterPregnancyConceptsAir pollutant exposureAdverse health effectsSpecific adverse health effectsOxidative stressHealth effectsPerturbation of metabolitesAir pollution exposureUntargeted metabolomicsPollutant exposureSteroid metabolic pathwaysPregnant womenInflammatory responseDisease continuumReviewThe purposeHealth outcomesLarger sample sizeMetabolic pathwaysDisease statusPollution exposureIdentified metabolitesMetabolic perturbationsMetabolic changesSummaryOur reviewAir pollution componentsMetabolomic analysis
2020
Accounting for urinary dilution in peri-implantation samples: implications for creatinine adjustment and specimen pooling
Rosen Vollmar AK, Johnson CH, Weinberg CR, Deziel NC, Baird DD, Wilcox AJ, Jukic AMZ. Accounting for urinary dilution in peri-implantation samples: implications for creatinine adjustment and specimen pooling. Journal Of Exposure Science & Environmental Epidemiology 2020, 31: 356-365. PMID: 32424331, PMCID: PMC7671945, DOI: 10.1038/s41370-020-0227-1.Peer-Reviewed Original ResearchConceptsCreatinine adjustmentCreatinine concentrationUrinary dilutionUrinary estrogen metabolitesEffect of pregnancyUrinary creatinine concentrationCreatinine levelsWeeks' gestationEarly pregnancyCreatinine excretionEstrogen metabolitesCreatinine measuresUrine specimensPooled measureBiomarker measurementsPooled specimensEnvironmental exposuresExposure measuresLinear mixed modelsBiomonitoring resultsPregnancyT-testKappa coefficientMixed modelsPerson sampleAnalyzing Metabolomics Data for Environmental Health and Exposome Research
Cai Y, Rosen Vollmar AK, Johnson CH. Analyzing Metabolomics Data for Environmental Health and Exposome Research. Methods In Molecular Biology 2020, 2104: 447-467. PMID: 31953830, DOI: 10.1007/978-1-0716-0239-3_22.Peer-Reviewed Original ResearchMeSH KeywordsChromatography, LiquidData AnalysisEnvironmental ExposureEnvironmental HealthExposomeMass SpectrometryMetabolomicsResearchRisk AssessmentConceptsLiquid chromatography-mass spectrometryChromatography-mass spectrometryBiological samplesExposure chemicalsExternal exposureSimultaneous analysisExposome researchHealth outcomesDisease preventionUnique advantagesBiological responsesUntargeted metabolomicsExposure risk assessmentHost susceptibilityMetabolomics technologyExposomeMetabolomic analysisRecent advancesSpectrometryExposureUntargeted metabolomics dataMetabolomicsHuman healthMetabolomics dataCumulative measure
2018
Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubber
Perkins AN, Inayat-Hussain SH, Deziel NC, Johnson CH, Ferguson SS, Garcia-Milian R, Thompson DC, Vasiliou V. Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubber. Environmental Research 2018, 169: 163-172. PMID: 30458352, PMCID: PMC6396308, DOI: 10.1016/j.envres.2018.10.018.Peer-Reviewed Original ResearchMeSH KeywordsCarcinogensElastomersEnvironmental ExposureEuropeHumansOrganic ChemicalsRubberUnited StatesConceptsSynthetic turf fieldsCrumb rubber infillEuropean Chemicals AgencyOrganic chemicalsUS EPAADMET PredictorRubber infillUnited States Environmental Protection AgencyFuture exposure studiesChemical constituentsStates Environmental Protection AgencyHazardous chemicalsComputational toxicologyChemical componentsVinyl chlorideChemicalsPriority carcinogensTurf fieldsToxicology assessmentEnvironmental Protection AgencyCarcinogenic chemicalsChemicals AgencyExposure studiesECHA databasePotential carcinogenicityBeyond genomics: understanding exposotypes through metabolomics
Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018, 12: 4. PMID: 29373992, PMCID: PMC5787293, DOI: 10.1186/s40246-018-0134-x.Peer-Reviewed Original ResearchConceptsGene-environment interactionsChallenges of metabolomicsIntegration of genomicsHuman genomeMultiple genetic variantsGenetic variationGenomic technologiesAssociation studiesMetabolic traitsMetabolite productionMetabolic processesIndividual phenotypesMetabolome-wide association studyProtein synthesisHuman population levelGenetic variantsBiological impactGenomicsDisease mechanismsMetabolomic informationWealth of informationPopulation levelSmall moleculesMetabolomicsTraits
2017
Yale school of public health symposium on lifetime exposures and human health: the exposome; summary and future reflections
Johnson CH, Athersuch TJ, Collman GW, Dhungana S, Grant DF, Jones DP, Patel CJ, Vasiliou V. Yale school of public health symposium on lifetime exposures and human health: the exposome; summary and future reflections. Human Genomics 2017, 11: 32. PMID: 29221465, PMCID: PMC5723043, DOI: 10.1186/s40246-017-0128-0.Peer-Reviewed Original ResearchEnvironmental ExposureEnvironmental HealthEnvironmental MonitoringHumansPublic HealthSocieties, Scientific