2020
Gene Alterations of N6‐Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study
Zhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Gene Alterations of N6‐Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study. BioMed Research International 2020, 2020: 8826456. PMID: 33415160, PMCID: PMC7769650, DOI: 10.1155/2020/8826456.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAgedAlpha-Ketoglutarate-Dependent Dioxygenase FTOColorectal NeoplasmsDatabases, GeneticDisease-Free SurvivalDNA Copy Number VariationsFemaleGene Expression Regulation, NeoplasticGenes, NeoplasmHumansMaleMultivariate AnalysisMutationNerve Tissue ProteinsPrognosisProportional Hazards ModelsRNA Splicing FactorsRNA, MessengerConceptsDisease-free survivalImmune cell infiltrationM6A regulatorsCRC patientsCRC casesCell infiltrationMRNA expressionWorse overall survivalN6-methyladenosine regulatorsMicrosatellite instability statusMessenger RNA expressionCancer Genome AtlasOverall survivalColorectal cancerCRC tissuesDatabase studyImmune functionInstability statusColon tissuesRole of m6AGene alterationsRNA expressionCRCGenome AtlasGenetic mutations
2017
Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics
Rattray NJW, Charkoftaki G, Rattray Z, Hansen JE, Vasiliou V, Johnson CH. Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics. Current Pharmacology Reports 2017, 3: 114-125. PMID: 28642837, PMCID: PMC5475285, DOI: 10.1007/s40495-017-0088-z.Peer-Reviewed Original ResearchColorectal cancerRisk of CRCPurpose of ReviewInGerm-line mutationsCRC casesCRC developmentExcessive alcoholMultifaceted etiologyPersonalized therapeutic interventionsTherapeutic interventionsSummaryThis reviewDietary metabolitesEtiologyHost metabolismEnvironmental exposuresGenetic polymorphismsCancerExposure eventsPrevailing majorityExposureAlcohol metabolic pathwayMetabolomicsCurrent understandingMetabolic pathwaysMicrobiome