Salome Charalambous
Associate Professor AdjunctCards
About
Research
Publications
2026
Differentiated HIV Service Delivery vs Conventional Care: Tuberculosis Preventive Therapy Outcomes for People Living With HIV in Sub-Saharan Africa
Johnson A, Chimoyi L, Charalambous S, Kawaza N, Hoffmann C, Davis J, Chihota V. Differentiated HIV Service Delivery vs Conventional Care: Tuberculosis Preventive Therapy Outcomes for People Living With HIV in Sub-Saharan Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2026, 101: 760-767. PMID: 41812010, DOI: 10.1097/qai.0000000000003864.Peer-Reviewed Original ResearchThis study found that differentiated HIV care models—community-based approaches to HIV care that have gained popularity in sub-Saharan Africa—achieved similar tuberculosis preventive therapy initiation rates as conventional clinic-based care but similarly low completion rates.Deep learning approach for probabilistic pulmonary function estimation from chest X-ray and peak expiratory flow rate
Killing C, Wekerle M, Sutherland J, Rassool M, Zurba L, Ivanova O, Charalambous S, Khosa C, Wallis R, Hoelscher M, Calderwood C, Allwood B, Castelletti N, Rachow A. Deep learning approach for probabilistic pulmonary function estimation from chest X-ray and peak expiratory flow rate. Communications Medicine 2026, 6: 330. PMID: 42265327, PMCID: PMC13249966, DOI: 10.1038/s43856-026-01702-7.Peer-Reviewed Original ResearchSafety of Short-course Weekly Rifapentine and Isoniazid (3HP) for TB Preventive Treatment at Conception and During First Trimester in Women With HIV: A Secondary Analysis of the WHIP3TB trial
Chihota V, Waggie Z, Cardenas V, Mngadi K, Ndebele F, Brumskine W, Sebe M, Martinson N, Wang S, Yimer G, Nguenha D, Garcia-Basteiro A, van den Hof S, Grant A, Charalambous S, Fielding K, Chaisson R, Churchyard G, Lebina L, Moloantoa T, Variava E, Holele I. Safety of Short-course Weekly Rifapentine and Isoniazid (3HP) for TB Preventive Treatment at Conception and During First Trimester in Women With HIV: A Secondary Analysis of the WHIP3TB trial. Clinical Infectious Diseases 2026, ciag315. PMID: 42142877, DOI: 10.1093/cid/ciag315.Peer-Reviewed Original ResearchCorrection: A study protocol to co-develop and evaluate interventions that strengthen healthcare resilience to extreme weather events in three African countries: the ASTRA study
Mabuto T, Orievulu K, Bond V, Simwinga M, Grapsa E, Khoza T, Khan-Gillmore S, Nzimande L, Craig M, Khagayi S, Chirwa T, Chiau R, Ossemane E, Hoffmann C, Seeley J, Kniveton D, Babashahi S, Rangunwala A, Mthembu N, Oberholzer C, Charalambous S, Iwuji C. Correction: A study protocol to co-develop and evaluate interventions that strengthen healthcare resilience to extreme weather events in three African countries: the ASTRA study. Frontiers In Climate 2026, 8: 1867599. DOI: 10.3389/fclim.2026.1867599.Commentaries, Editorials and LettersWhole genome sequencing precision medicine strategy to shorten treatment for rifampicin-resistant tuberculosis (SMARTT): a pragmatic, randomised, single-blind phase 4 trial
Van Rie A, Conceição E, Ndebele F, Wells F, Paulse A, Mekonnen E, Ngarega M, Trang T, Bohlela S, Sibeko Z, Segwaba P, Verboven L, Heupink T, Fuertes M, Rennie V, Dippenaar A, Rigouts L, Setlhare L, Ogunbayo A, VanderSpoel Van Dyk A, Conradie F, Maartens G, Potgieter S, Black J, Fanampe B, Abrams S, Churchyard G, Warren R, Charalambous S. Whole genome sequencing precision medicine strategy to shorten treatment for rifampicin-resistant tuberculosis (SMARTT): a pragmatic, randomised, single-blind phase 4 trial. The Lancet Respiratory Medicine 2026, 14: 521-532. PMID: 42026006, DOI: 10.1016/s2213-2600(26)00095-0.Peer-Reviewed Original ResearchDynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries
Saavedra-Cervera B, Nguenha D, Chihota V, Yimer G, Fernández-Escobar C, Mngadi K, Brumskine W, Martinson N, Wang S, Masilela L, Waggie Z, Martínez L, van den Hof S, Charalambous S, Cobelens F, Chaisson R, Grant A, Fielding K, Churchyard G, Garcia-Basteiro A. Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries. Journal Of Infectious Diseases 2026, jiag165. PMID: 41843759, DOI: 10.1093/infdis/jiag165.Peer-Reviewed Original ResearchQualitative Identification of HIV Care Engagement Challenges and Preferences for Differentiated Care Service Delivery Models Post-Incarceration in South Africa
Mqedlana-Ntombela N, Mabuto T, Owczarzak J, Charalambous S, Hoffmann C. Qualitative Identification of HIV Care Engagement Challenges and Preferences for Differentiated Care Service Delivery Models Post-Incarceration in South Africa. INQUIRY The Journal Of Health Care Organization Provision And Financing 2026, 63: 00469580261421077. PMID: 42273995, PMCID: PMC13261031, DOI: 10.1177/00469580261421077.Peer-Reviewed Original ResearchpanTB-HM: a multi-arm clinical trial of a pan-TB regimen targeting both host and microbe
Mudzengi D, Mashatole S, Xiang Q, Adrion C, Glover N, Ngwanto T, Mdluli J, Boniface S, Rassool M, Matome B, Paramo L, Svensson E, Fasanmi A, Angelo S, Moyo M, Marx C, Khosa C, Mokaba L, Mofokeng N, Lalashowi J, Nacy C, Charalambous S, Fumane E, Maphossa V, Beattie T, Brumskine W, Venter C, Mapamba D, Heinrich N, Rajaram S, Kooverjee S, Botha L, Nell M, Easton A, Foraida S, Warren R, Sabi I, Ntinginya N, Wallis R. panTB-HM: a multi-arm clinical trial of a pan-TB regimen targeting both host and microbe. Trials 2026, 27: 271. PMID: 41749341, PMCID: PMC13049951, DOI: 10.1186/s13063-026-09568-9.Peer-Reviewed Original ResearchHost response biomarkers of tuberculosis recurrence and treatment failure
Bauer B, Ahmed M, Baranov O, Bakuli A, Lin L, Kisinda A, Chachage M, Ntinginya N, Khosa C, Hoelscher M, Rassool M, Charalambous S, Sutherland J, Held K, Rachow A, Geldmacher C. Host response biomarkers of tuberculosis recurrence and treatment failure. Communications Medicine 2026, 6: 184. PMID: 41691044, PMCID: PMC13047042, DOI: 10.1038/s43856-026-01424-w.Peer-Reviewed Original ResearchInsights on the implementation strategies for a potential new tuberculosis vaccine in South Africa
Thomas K, Okoro C, Ntshiqa T, Damovsky V, Goldberg D, Ramokhoase O, Clark R, Jassat W, Churchyard G, Abdullah F, Kubjane M, Seeley J, Charalambous S, White R. Insights on the implementation strategies for a potential new tuberculosis vaccine in South Africa. PLOS Global Public Health 2026, 6: e0005047. PMID: 41616046, PMCID: PMC12858010, DOI: 10.1371/journal.pgph.0005047.Peer-Reviewed Original Research