Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramBody mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study
Lv Y, Zhang Y, Li X, Gao X, Ren Y, Deng L, Xu L, Zhou J, Wu B, Wei Y, Cui X, Xu Z, Guo Y, Qiu Y, Ye L, Chen C, Wang J, Li C, Luo Y, Yin Z, Mao C, Yu Q, Lu H, Kraus V, Zeng Y, Tong S, Shi X. Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study. European Heart Journal 2024, 45: 2145-2154. PMID: 38626306, PMCID: PMC11212828, DOI: 10.1093/eurheartj/ehae206.Peer-Reviewed Original ResearchChinese Longitudinal Healthy Longevity SurveyHigher body mass indexAssociation of body mass indexBody mass indexNon-CVD mortalityOldest-old peopleWaist circumferenceOldest-oldMortality riskMendelian randomizationSingle-nucleotide polymorphismsInverse relationship of BMIStudies of body mass indexRelationship of body mass indexCardiovascular diseaseOptimal body mass indexMass indexAssociated with body mass indexCardiovascular disease mortalityMendelian randomization studiesAssociated with decreased mortality riskGenetic risk scoreNon-linear MR analysisLower mortality riskJoint effect analysisAssociations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China
Ni W, Lv Y, Yuan X, Zhang Y, Zhang H, Zheng Y, Shi X, Xu J. Associations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae116. PMID: 38436437, DOI: 10.1210/clinem/dgae116.Peer-Reviewed Original ResearchCause-specific mortalityAssociation of low-density lipoprotein cholesterolAll-causeOlder adultsLDL-C levelsLow-density lipoprotein cholesterolAssociated with increased cancer mortalityHazard ratioRisk of all-cause mortalityCVD-specific mortalityLDL-CMultivariable-adjusted HRCardiovascular diseaseProspective cohort studyLipoprotein cholesterolAll-cause mortalityCox proportional hazards modelsOther-cause mortalityHealthy aging researchProportional hazards modelCancer mortalityVital statusMultivariate Cox proportional hazards modelLow LDL-C levelsMedian follow-up time