2022
Treatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China: an observational cohort study
Jia J, Zhu Q, Deng L, Lan G, Johnson A, Chen H, Shen Z, Li J, Xing H, Ruan Y, Li J, Lu H, Vermund SH, Zhu J, Qian HZ. Treatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China: an observational cohort study. Infectious Diseases Of Poverty 2022, 11: 7. PMID: 34986877, PMCID: PMC8734096, DOI: 10.1186/s40249-021-00921-5.Peer-Reviewed Original ResearchMeSH KeywordsChinaCohort StudiesCoinfectionHepatitis BHepatitis B virusHepatitis CHIV InfectionsHumansPrevalenceRetrospective StudiesTreatment OutcomeConceptsHepatitis B virusHepatitis C virusAntiretroviral therapyHigh mortalityHCV coinfectionC virusNational Free Antiretroviral Treatment ProgramHBV co-infected patientsHBV/HCV coinfectionRetrospective cohort study analysisEffect of ARTCohort study analysisObservational cohort studyAntiretroviral treatment programOverall mortality rateProportional hazards modelTreatment attrition rateCause deathHCV-coHIV patientsBaseline infectionCohort studyHBV-HCVHepatitis BHepatitis treatment
2016
Engagement of Men in Antenatal Care Services: Increased HIV Testing and Treatment Uptake in a Community Participatory Action Program in Mozambique
Audet CM, Blevins M, Chire YM, Aliyu MH, Vaz LM, Antonio E, Alvim F, Bechtel R, Wester CW, Vermund SH. Engagement of Men in Antenatal Care Services: Increased HIV Testing and Treatment Uptake in a Community Participatory Action Program in Mozambique. AIDS And Behavior 2016, 20: 2090-2100. PMID: 26906021, PMCID: PMC4995150, DOI: 10.1007/s10461-016-1341-x.Peer-Reviewed Original ResearchConceptsAntenatal careHIV testingPregnant womenProvider-initiated counselingAntenatal care servicesAntiretroviral therapy servicesPre-post intervention designUptake of ARTTraditional birth attendantsMale engagementCommunity health agentsRate of testingANC servicesTreatment uptakeBirth attendantsService uptakePartner's pregnancyCare servicesTherapy servicesHealth agentsTreatment acceptabilityMale partnersSimilar interventionsMale championsPregnancy
2015
The Effect of Cryotherapy on Human Papillomavirus Clearance Among HIV-Positive Women in Lusaka, Zambia
Katundu K, Bateman AC, Pfaendler KS, Mwanahamuntu MH, Kapambwe S, Vermund SH, Sahasrabuddhe VV, Msadabwe SC, Stringer JS, Parham GP, Chibwesha CJ. The Effect of Cryotherapy on Human Papillomavirus Clearance Among HIV-Positive Women in Lusaka, Zambia. Journal Of Lower Genital Tract Disease 2015, 19: 301-306. PMID: 26125097, PMCID: PMC4583804, DOI: 10.1097/lgt.0000000000000131.Peer-Reviewed Original ResearchConceptsHIV-positive womenWeeks of treatmentHrHPV infectionHrHPV typesHigh-risk HPV cervical infectionHigh HIV burden settingsHIV burden settingsHPV cervical infectionHuman papillomavirus clearancePrevalence of hrHPVCommon HPV typesHuman papillomavirus infectionRoche Linear ArrayEffects of cryotherapyHPV vaccinationMedian CD4Antiretroviral therapyCervical infectionCohort studyPapillomavirus infectionBurden settingsCervical diseaseHPV typesMedian ageCervical screening
2014
Poor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement
Vermund SH, Blevins M, Moon TD, José E, Moiane L, Tique JA, Sidat M, Ciampa PJ, Shepherd BE, Vaz LM. Poor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement. PLOS ONE 2014, 9: e110116. PMID: 25330113, PMCID: PMC4203761, DOI: 10.1371/journal.pone.0110116.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyInfant diagnosisClinical outcomesEarly infant diagnosisPoor clinical outcomeYears of ageResource-limited settingsUnknown clinical outcomesCohort mortality ratesQuality improvement effortsART initiationCART initiationRural MozambiqueHIV servicesAdults 15HIV prevalenceKaplan-MeierHigher hemoglobinMedication pickupClinical dataOutcome treatmentNational guidelinesCase findingZambézia ProvincePediatric Malignancies, Treatment Outcomes and Abandonment of Pediatric Cancer Treatment in Zambia
Slone JS, Chunda-Liyoka C, Perez M, Mutalima N, Newton R, Chintu C, Kankasa C, Chipeta J, Heimburger DC, Vermund SH, Friedman DL. Pediatric Malignancies, Treatment Outcomes and Abandonment of Pediatric Cancer Treatment in Zambia. PLOS ONE 2014, 9: e89102. PMID: 24586527, PMCID: PMC3931678, DOI: 10.1371/journal.pone.0089102.Peer-Reviewed Original ResearchConceptsUniversity Teaching HospitalPediatric oncology wardOncology wardTreatment abandonmentRisk factorsTreatment outcomesRetrospective cohort studyAbandonment of treatmentMode of diagnosisCohort of childrenClinical medical recordsStudy time periodCohort studyOncologic treatmentTreatment regimenMultivariable analysisMedical recordsTeaching hospitalInclusion criteriaLower riskCancerChildrenTreatmentWardsDiagnosisHPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm B
2013
Haemoglobin recovery among HIV-1 infected patients on zidovudine-based antiretroviral therapy and other regimens in north-central Nigeria
Parrish DD, Blevins M, Megazzini KM, Shepherd BE, Mohammed MY, Wester CW, Vermund SH, Aliyu MH. Haemoglobin recovery among HIV-1 infected patients on zidovudine-based antiretroviral therapy and other regimens in north-central Nigeria. International Journal Of STD & AIDS 2013, 25: 355-359. PMID: 24104694, PMCID: PMC4385388, DOI: 10.1177/0956462413506887.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveDrug Therapy, CombinationFemaleHemoglobinsHIV InfectionsHumansLinear ModelsMaleMiddle AgedNigeriaRetrospective StudiesReverse Transcriptase InhibitorsRural PopulationSocioeconomic FactorsTime FactorsTreatment OutcomeZidovudineConceptsBaseline hemoglobin levelCombination antiretroviral therapyHemoglobin levelsAntiretroviral therapyHemoglobin recoveryNon-pregnant adult patientsUse of zidovudineZidovudine-containing regimenZidovudine-containing regimensNorth Central NigeriaGroup of patientsRural North-Central NigeriaMeasures of hemoglobinZidovudine useBaseline hemoglobinAdult patientsMedian hemoglobinHemoglobin responseHIV-1PatientsZidovudineHemoglobin dataHemoglobinRegimensTherapy
2012
Availability of Volunteer-Led Home-Based Care System and Baseline Factors as Predictors of Clinical Outcomes in HIV-Infected Patients in Rural Zambia
Estopinal CB, van Dijk JH, Sitali S, Stewart H, Davidson MA, Spurrier J, Vermund SH. Availability of Volunteer-Led Home-Based Care System and Baseline Factors as Predictors of Clinical Outcomes in HIV-Infected Patients in Rural Zambia. PLOS ONE 2012, 7: e49564. PMID: 23236351, PMCID: PMC3517597, DOI: 10.1371/journal.pone.0049564.Peer-Reviewed Original ResearchConceptsBody mass indexHome-based careLower body mass indexART initiationAntiretroviral therapyUnfavorable outcomeTreatment outcomesFavorable outcomeRural Southern ProvinceCell countRetrospective cohort studyImproved treatment outcomesEligible patientsHBC programmesLow CD4HIV careAdherence counselingCohort studyDate of birthBaseline factorsMedical chartsBivariable analysisClinical outcomesMass indexMultivariable analysis
2011
Effectiveness of a School-Based Deworming Campaign in Rural Kenya
Peterson LS, Ondiek M, Oludhe DO, Naul BA, Vermund SH. Effectiveness of a School-Based Deworming Campaign in Rural Kenya. Journal Of Tropical Pediatrics 2011, 57: 461-463. PMID: 21212131, DOI: 10.1093/tropej/fmq118.Peer-Reviewed Original ResearchConceptsDeworming campaignsIntestinal helminth infectionsSingle stool sampleRe-infection rateDirect stool smearDirect smear examinationHeavy environmental contaminationPrimary school-aged childrenSchool-aged childrenStool samplesStool surveyHelminth infectionsSmear examinationStool smearsHeavy infectionsSchool childrenInfectionRural KenyaChildrenParasite prevalenceCommunity educationSanitation improvementTrue rateDefinitive impactPrevalence
2010
A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia
Megazzini KM, Sinkala M, Vermund SH, Redden DT, Krebs DW, Acosta EP, Mwanza J, Goldenberg RL, Chintu N, Bulterys M, Stringer JS. A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia. AIDS 2010, 24: 447-455. PMID: 19926959, DOI: 10.1097/qad.0b013e328334b285.Peer-Reviewed Original ResearchConceptsWomen/infant pairsCluster-randomized trialNevirapine coverageInfant pairsLabour wardClinic coverageProbability of HIVProportion of HIVPrevention of motherStandard of carePMTCT programmePMTCT servicesChild transmissionHIV testingUnknown serostatusSurveillance periodIntervention periodControl clinicsRelative riskTreatment clinicsUmbilical cordHIVClinicGEE modelOdds of coverage
2009
Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project
Ding H, Wilson CM, Modjarrad K, McGwin G, Tang J, Vermund SH. Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project. JAMA Pediatrics 2009, 163: 1100-1105. PMID: 19996046, PMCID: PMC3739292, DOI: 10.1001/archpediatrics.2009.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChi-Square DistributionFemaleHIV InfectionsHumansInterviews as TopicLogistic ModelsMalePatient CompliancePredictive Value of TestsPrevalenceProspective StudiesStatistics, NonparametricTreatment OutcomeUnited StatesViral LoadYoung AdultConceptsHuman immunodeficiency virus-infected adolescentsSuboptimal virologic responsePoor virologic responseVirologic responseActive antiretroviral therapyAntiretroviral therapyVirologic suppressionMultivariable logistic regression modelDual antiretroviral therapyInitiation of HAARTSuboptimal antiretroviral therapyAge-specific interventionsAcademic medical centerLogistic regression modelsCohort studyLymphocyte countViral loadEcho findingsAdequate adherenceTherapeutic failureBiopsychosocial predictorsHAARTMedical CenterAdolescent careConsecutive visitsSelected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol
Mwinga K, Vermund SH, Chen YQ, Mwatha A, Read JS, Urassa W, Carpenetti N, Valentine M, Goldenberg RL. Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol. BMC Pediatrics 2009, 9: 49. PMID: 19664210, PMCID: PMC2746190, DOI: 10.1186/1471-2431-9-49.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsBlood Cell CountDouble-Blind MethodFemaleFollow-Up StudiesGestational AgeHematocritHemoglobinsHIVHIV InfectionsHumansIncidenceInfantInfant, NewbornMalawiNevirapinePregnancyPregnancy Complications, InfectiousRetrospective StudiesRNA, ViralTanzaniaTreatment OutcomeYoung AdultZambiaConceptsHIV infectionPregnant African womenRandomized clinical trialsTime of laborComplete laboratory dataWeeks of ageNevirapine prophylaxisChild transmissionHIV exposureWeeks' gestationHIV statusPregnant womenNewborn infantsClinical trialsPublic clinicsHIVInfantsBiochemical measurementsCaucasian populationWomenLaboratory dataNormative dataAfrican womenInfectionWeeks
2007
Syndromic management training for non-formal care providers in Pakistan improves quality of care for sexually transmitted diseases STD care: a randomized clinical trial.
Shah SA, Kristensen S, Memon MA, White HL, Vermund SH. Syndromic management training for non-formal care providers in Pakistan improves quality of care for sexually transmitted diseases STD care: a randomized clinical trial. The Southeast Asian Journal Of Tropical Medicine And Public Health 2007, 38: 737-48. PMID: 17883016.Peer-Reviewed Original ResearchConceptsSTD careIntervention groupCare providersControl groupRandomized clinical trialsThree-armed trialQuality of careCase management servicesSTD servicesSyndromic managementClinical trialsCondom provisionCondom useNon-formal providersExit interviewsCareTrialsGroupProvidersService deliveryManagement trainingPatientsReferralMore knowledgeMonthsMonitoring and evaluation of programmes to prevent mother to child transmission of HIV in Africa
Reithinger R, Megazzini K, Durako SJ, Harris DR, Vermund SH. Monitoring and evaluation of programmes to prevent mother to child transmission of HIV in Africa. The BMJ 2007, 334: 1143. PMID: 17540943, PMCID: PMC1885318, DOI: 10.1136/bmj.39211.527488.94.Peer-Reviewed Original ResearchEarly clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine
H BH, Sinkala M, Stringer EM, Cantrell RA, Mtonga V, Bulterys M, Zulu I, Kankasa C, Wilfert C, Weidle PJ, Vermund SH, Stringer J. Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine. AIDS 2007, 21: 957-964. PMID: 17457089, PMCID: PMC2745970, DOI: 10.1097/qad.0b013e32810996b2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountDrug Administration ScheduleEpidemiologic MethodsFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalNevirapinePregnancyPregnancy Complications, InfectiousReverse Transcriptase InhibitorsTreatment FailureTreatment OutcomeConceptsSingle-dose nevirapineClinical treatment failureCD4 cell responseAntiretroviral therapyTreatment failureNVP exposureTreatment outcomesCell responsesShort-term treatment outcomesPrior exposureChild HIV transmissionPrevention of motherCD4 cell changesPoor treatment outcomesNon-nucleoside reverseSignificant differencesWorld Health Organization guidelinesHealth Organization guidelinesART initiationCohort evaluationMultivariable analysisHIV transmissionHIV treatmentRisk factorsImmune response
2005
An Intervention to Reduce Vaginal Douching Among Adolescent and Young Adult Women: A Randomized, Controlled Trial
Grimley DM, Oh MK, Desmond RA, Hook EW, Vermund SH. An Intervention to Reduce Vaginal Douching Among Adolescent and Young Adult Women: A Randomized, Controlled Trial. Sexually Transmitted Diseases 2005, 32: 752-758. PMID: 16314772, DOI: 10.1097/01.olq.0000190018.58079.05.Peer-Reviewed Original ResearchConceptsVaginal douchingYoung adult womenAdult womenIndividualized counseling sessionsTreat modelPrimary outcome measureStage of readinessSecondary outcomesIntervention groupOutcome measuresStages of changeHealthy eatingStage-matched interventionsYoung womenDouchingYoung adultsComparison groupWomenMonthsCounseling sessionsInterventionExperimental groupTrialsCessationComparison conditionTreatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults
Modjarrad K, Zulu I, Redden DT, Njobvu L, Lane HC, Bentwich Z, Vermund SH. Treatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults. The Journal Of Infectious Diseases 2005, 192: 1277-1283. PMID: 16136473, PMCID: PMC2730764, DOI: 10.1086/444543.Peer-Reviewed Original ResearchConceptsHIV-1 RNAViral loadPlasma concentrationsAntihelminthic treatmentCopies/Helminth infectionsIntestinal helminthsHigh pretreatment viral loadMedian baseline viral loadPretreatment viral loadBaseline viral loadDysfunctional immune responseIntestinal helminth infectionsHuman immunodeficiency virusMean viral loadCopies/mLHigher helminth burdensPosttreatment visitAsymptomatic adultsImmunodeficiency virusProspective studyZambian adultsUninfected groupHIV-1Immune responseEffectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia
Stringer JS, Sinkala M, Maclean CC, Levy J, Kankasa C, DeGroot A, Stringer EM, Acosta EP, Goldenberg RL, Vermund SH. Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia. AIDS 2005, 19: 1309-1315. PMID: 16052086, PMCID: PMC2745046, DOI: 10.1097/01.aids.0000180102.88511.7d.Peer-Reviewed Original ResearchConceptsMother-infant pairsHIV testingCord bloodSurveillance populationAntenatal HIV testingPerinatal HIV preventionProportion of HIVChild HIV transmissionHIV test resultsMain outcome measuresNewborn cord bloodHIV prevention programsHIV serologyInfant dosePublic sector facilitiesSeropositive womenAntenatal careHIV transmissionPrescribed regimenCascade of eventsLabor onsetPopulation effectivenessSurveillance periodHIV preventionOutcome measures
1996
Ethical issues for perinatal HIV trials in developing countries.
Phanuphak P, Vermund SH. Ethical issues for perinatal HIV trials in developing countries. AIDS Patient Care And STDs 1996, 7: 236-8. PMID: 11361714.Peer-Reviewed Original ResearchAnti-HIV AgentsControl GroupsDeveloping CountriesEthical RelativismEthics, MedicalFemaleGestational AgeHealth Care RationingHIV InfectionsHumansInfant, NewbornInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousPregnant WomenTherapeutic Human ExperimentationTreatment OutcomeZidovudine