2021
Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies
Chen Y, Gao Y, Zhou Y, Li X, Wang H, Polonsky TS, Vermund SH, Qian HZ, Qian F. Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 87: 741-749. PMID: 33492019, PMCID: PMC10768809, DOI: 10.1097/qai.0000000000002629.Peer-Reviewed Original ResearchMeSH KeywordsAdultCD4 Lymphocyte CountDatabases, FactualFemaleHeart FailureHIV InfectionsHumansIncidenceProspective StudiesRiskConceptsIncident heart failureLow CD4 countHeart failureHIV infectionRandom-effects modelCD4 countSubgroup analysisRisk of HFHuman immunodeficiency virus (HIV) infectionLaird random-effects modelYoung adultsAvailable prospective evidenceImmunodeficiency virus infectionPooled relative riskFull-text assessmentWeb of ScienceFixed-effects modelProspective studyIncident casesProspective evidenceRelative riskVirus infectionFunnel plotMeta-AnalysisSimilar association
2018
Severe outcomes associated with respiratory viruses in newborns and infants: a prospective viral surveillance study in Jordan
Khuri-Bulos N, Lawrence L, Piya B, Wang L, Fonnesbeck C, Faouri S, Shehabi A, Vermund SH, Williams JV, Halasa NB. Severe outcomes associated with respiratory viruses in newborns and infants: a prospective viral surveillance study in Jordan. BMJ Open 2018, 8: e021898. PMID: 29780032, PMCID: PMC5961648, DOI: 10.1136/bmjopen-2018-021898.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAntiviral AgentsFemaleHumansInfantIntensive Care UnitsJordanLength of StayMaleOxygen Inhalation TherapyPalivizumabParainfluenza Virus 1, HumanProspective StudiesRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesRespiratory Syncytial Virus, HumanRespiratory Tract InfectionsRhinovirusRisk FactorsConceptsLonger LOSLength of stayAcute respiratory infectionsIntensive care unitRespiratory syncytial virusOxygen therapyMechanical ventilationHospitalisation ratesICU admissionIllness severityRespiratory virusesMedical conditionsExtended breast feedingRSV vaccine developmentProspective cohort studyUnderlying medical conditionsChemotherapy-associated neutropeniaHuman parainfluenza virusesYears of ageCohort studyRespiratory symptomsBreast feedingRespiratory infectionsCare unitSyncytial virus
2017
Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool
Sileshi B, Newton MW, Kiptanui J, Shotwell MS, Wanderer JP, Mungai M, Scherdin J, Harris PA, Vermund SH, Sandberg WS, McEvoy MD. Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool. Anesthesiology 2017, 127: 250-271. PMID: 28657959, PMCID: PMC5519082, DOI: 10.1097/aln.0000000000001713.Peer-Reviewed Original ResearchConceptsPerioperative dataPerioperative mortality rateTertiary referral hospitalMortality rate differencesAnesthesia care deliveryLogistic regression modelsMiddle-income settingsPerioperative mortalityCesarean deliveryEmergency surgeryMiddle-income countriesPerioperative careReferral hospitalSurgery typeSingle centerProcedure typeGeneral surgeryHigh riskMortality rateCare deliveryMortalityData collection periodData collection toolSurgeryRegression modelsImpact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China
Tao J, Vermund SH, Lu H, Ruan Y, Shepherd BE, Kipp AM, Amico KR, Zhang X, Shao Y, Qian HZ. Impact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China. AIDS Patient Care And STDs 2017, 31: 96-104. PMID: 28170305, PMCID: PMC5312604, DOI: 10.1089/apc.2016.0214.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART initiationHIV diagnosisHIV infectionDepression scoresEarly ART initiationNational ART databaseNew HIV diagnosesImpact of depressionEffect of depressionProspective cohortBorderline depressionCox regressionHADS scoresBaseline prevalenceEligible participantsHospital AnxietyBorderline anxietyDepression ScaleDoctor's adviceChinese MSMChinese menSymptom severityHIVAnxiety scoresEffects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM
Tao J, Qian HZ, Kipp AM, Ruan Y, Shepherd BE, Amico KR, Shao Y, Lu H, Vermund SH. Effects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM. AIDS 2017, 31: 401-406. PMID: 27677168, PMCID: PMC5233466, DOI: 10.1097/qad.0000000000001287.Peer-Reviewed Original ResearchConceptsImperfect ART adherenceEffect of depressionART adherenceAntiretroviral therapyHIV infectionChinese MSMHIV treatment outcomesAntiretroviral therapy adherenceEnd of studyMixed-effects logistic regressionHIV diagnosisOne-unit increaseProspective studyTherapy adherenceHospital AnxietyRisk factorsTreatment outcomesDepression ScaleSignificant associationIntensive interventionLogistic regressionMSMAnxiety scoresAdherenceInfection
2016
Rates and determinants of incidence and clearance of cervical HPV genotypes among HIV-seropositive women in Pune, India
Mane A, Sahasrabuddhe VV, Nirmalkar A, Risbud AR, Sahay S, Bhosale RA, Vermund SH, Mehendale SM. Rates and determinants of incidence and clearance of cervical HPV genotypes among HIV-seropositive women in Pune, India. Journal Of Clinical Virology 2016, 88: 26-32. PMID: 28152432, PMCID: PMC5441893, DOI: 10.1016/j.jcv.2016.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultCervix UteriFemaleGenotypeHIV InfectionsHumansIncidenceIndiaPapillomaviridaePapillomavirus InfectionsProspective StudiesConceptsHIV-seropositive womenCervical HPV genotypesHPV genotypesClearance rateHPV infectionAge-related hormonal changesRoche Linear Array HPVAlpha-7 speciesAntiretroviral therapy statusCarcinogenic HPV genotypesCervical HPV infectionGenotype-specific prevalenceLinear Array HPVAge of participantsCD4 countHPV incidenceImmunologic factorsDeterminants of incidenceHPV typesTherapy statusProspective studyCervical samplesIncidence rateHormonal changesEtiologic studies
2015
The Effect of Cryotherapy on Human Papillomavirus Clearance Among HIV-Positive Women in Lusaka, Zambia
Katundu K, Bateman AC, Pfaendler KS, Mwanahamuntu MH, Kapambwe S, Vermund SH, Sahasrabuddhe VV, Msadabwe SC, Stringer JS, Parham GP, Chibwesha CJ. The Effect of Cryotherapy on Human Papillomavirus Clearance Among HIV-Positive Women in Lusaka, Zambia. Journal Of Lower Genital Tract Disease 2015, 19: 301-306. PMID: 26125097, PMCID: PMC4583804, DOI: 10.1097/lgt.0000000000000131.Peer-Reviewed Original ResearchConceptsHIV-positive womenWeeks of treatmentHrHPV infectionHrHPV typesHigh-risk HPV cervical infectionHigh HIV burden settingsHIV burden settingsHPV cervical infectionHuman papillomavirus clearancePrevalence of hrHPVCommon HPV typesHuman papillomavirus infectionRoche Linear ArrayEffects of cryotherapyHPV vaccinationMedian CD4Antiretroviral therapyCervical infectionCohort studyPapillomavirus infectionBurden settingsCervical diseaseHPV typesMedian ageCervical screeningNatural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan
Halasa N, Williams J, Faouri S, Shehabi A, Vermund SH, Wang L, Fonnesbeck C, Khuri-Bulos N. Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan. Vaccine 2015, 33: 6479-6487. PMID: 26314623, PMCID: PMC7115487, DOI: 10.1016/j.vaccine.2015.08.048.Peer-Reviewed Original ResearchMeSH KeywordsEpidemiological MonitoringFemaleHospitalsHumansInfantInfant, NewbornJordanMaleMass SpectrometryNasal MucosaPharynxPrevalenceProspective StudiesReal-Time Polymerase Chain ReactionRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsReverse Transcriptase Polymerase Chain ReactionRisk FactorsVitamin DConceptsRespiratory syncytial virusRSV-positive childrenVitamin D levelsD levelsRespiratory virusesRisk factorsMedical conditionsBurden of RSVOxygen useMedian vitamin D levelNasal/throat swabsRespiratory syncytial virus infectionCause of bronchiolitisHeel stick bloodSyncytial virus infectionLack of breastfeedingSupplemental oxygen useHigh viral loadFuture RSV vaccinesYoung childrenReal-time RT-PCRRSV hospitalizationRespiratory symptomsRSV vaccineAntiviral therapyPractical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline
Brentlinger PE, Silva WP, Vermund SH, Valverde E, Buene M, Moon TD. Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline. AIDS Research And Human Retroviruses 2015, 32: 12-25. PMID: 26178574, PMCID: PMC4692124, DOI: 10.1089/aid.2015.0030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAnthelminticsAnti-HIV AgentsAntimalarialsAntitubercular AgentsCD4 Lymphocyte CountCoinfectionDeveloping CountriesDisease ManagementFemaleHelminthiasisHemoglobinsHIV InfectionsHumansLost to Follow-UpMalaria, FalciparumMaleMozambiquePractice Guidelines as TopicProspective StudiesRural PopulationTuberculosis, PulmonaryConceptsHIV-associated anemiaAdverse drug reactionsDrug reactionsHemoglobin responseGuideline revisionsIron deficiencyLower body mass indexCo-trimoxazole prophylaxisDiscontinuation of zidovudineLaboratory-confirmed malariaProspective observational evaluationRural Zambézia ProvinceT-cell countsT-lymphocyte countsSmear-positive tuberculosisBody mass indexResource limited settingsResource-limited settingsLogistic regression modelsAnaemic HIVStudy cliniciansAntiretroviral therapyEsophageal candidiasisPresumptive treatmentAnemia management
2014
Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings
Brentlinger PE, Silva WP, Buene M, Morais L, Valverde E, Vermund SH, Moon TD. Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 304-309. PMID: 25314251, PMCID: PMC5844466, DOI: 10.1097/qai.0000000000000304.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory CareAnti-Bacterial AgentsAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBacterial InfectionsCD4 Lymphocyte CountDisease ManagementFemaleFeverHIV InfectionsHumansMaleMultivariate AnalysisOutcome Assessment, Health CarePractice Guidelines as TopicProspective StudiesRisk FactorsViral LoadConceptsManagement of feverLow CD4 T-lymphocyte countCD4 T-lymphocyte countLower body mass indexBacterial blood stream infectionsSpecific alternative diagnosesT-lymphocyte countsHistory of feverProspective observational studyBlood stream infectionsBody mass indexResource limited settingsAmbulatory HIVAntiretroviral therapyMalaria testingLower hemoglobinMass indexAdverse outcomesAlternative diagnosesObservational studyAxillary temperatureGuideline performanceMultivariate analysisHIVFever
2013
Bacteremia as a Cause of Fever in Ambulatory, HIV-Infected Mozambican Adults: Results and Policy Implications from a Prospective Observational Study
Moon TD, Silva WP, Buene M, Morais L, Valverde E, Vermund SH, Brentlinger PE. Bacteremia as a Cause of Fever in Ambulatory, HIV-Infected Mozambican Adults: Results and Policy Implications from a Prospective Observational Study. PLOS ONE 2013, 8: e83591. PMID: 24386229, PMCID: PMC3875454, DOI: 10.1371/journal.pone.0083591.Peer-Reviewed Original ResearchConceptsProspective observational studyAmbulatory HIVFebrile patientsObservational studySusceptibility patternsLarge prospective observational studyT-lymphocyte countsSpecific antimicrobial therapyCause of feverCases of bacteremiaFirst-line antibioticsPeripheral health unitsAntimicrobial susceptibility patternsNon-physician cliniciansNon-typhoid SalmonellaResource-limited settingsBlood culture specimensLow CD4Presumptive antibioticsClinical characteristicsRecent feverClinical profileLower hemoglobinPrescribing practicesAntimicrobial therapy
2010
Cost comparison of microscopy vs. empiric treatment for malaria in southwestern nigeria: a prospective study
Parikh R, Amole I, Tarpley M, Gbadero D, Davidson M, Vermund SH. Cost comparison of microscopy vs. empiric treatment for malaria in southwestern nigeria: a prospective study. Malaria Journal 2010, 9: 371. PMID: 21176228, PMCID: PMC3152770, DOI: 10.1186/1475-2875-9-371.Peer-Reviewed Original ResearchConceptsEmpiric treatmentAnti-malarial drugsClinical diagnosisClinical malariaGiemsa smearsMajority of patientsUniversity Teaching HospitalCases of malariaRapid diagnostic testsResource-limited settingsCost of diagnosisBody achesHospital chargesProspective studyTreatment optionsPatient costsPediatric regimenTeaching hospitalDiagnostic confirmationEmpirical treatmentThick smearsClinician judgmentAntimalarial drugsDrug resistanceMalariaBurden of respiratory syncytial virus in hospitalized infants and young children in Amman, Jordan
Khuri-Bulos N, Williams JV, Shehabi AA, Faouri S, Al Jundi E, Abushariah O, Chen Q, Ali SA, Vermund S, Halasa NB. Burden of respiratory syncytial virus in hospitalized infants and young children in Amman, Jordan. Infectious Diseases 2010, 42: 368-374. PMID: 20100116, PMCID: PMC2854220, DOI: 10.3109/00365540903496544.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsCost of IllnessFemaleHospitalizationHumansInfantJordanLength of StayMaleMiddle EastNosePharynxPrevalenceProspective StudiesRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanReverse Transcriptase Polymerase Chain ReactionRNA, ViralSex FactorsUnited StatesConceptsAcute respiratory infectionsMedian ageNose/throat swabsRespiratory syncytial virus seasonChildren's median ageRSV-negative childrenRSV-positive childrenSpecific viral causeLonger hospital stayHigher hospital chargesIntensive care unitRespiratory syncytial virusReal-time polymerase chain reactionLower median ageEffective preventive measuresJordanian infantsHospital stayHospitalized infantsRSV vaccineRespiratory infectionsCare unitHospital chargesSyncytial virusThroat swabsViral cause
2009
Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project
Ding H, Wilson CM, Modjarrad K, McGwin G, Tang J, Vermund SH. Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project. JAMA Pediatrics 2009, 163: 1100-1105. PMID: 19996046, PMCID: PMC3739292, DOI: 10.1001/archpediatrics.2009.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChi-Square DistributionFemaleHIV InfectionsHumansInterviews as TopicLogistic ModelsMalePatient CompliancePredictive Value of TestsPrevalenceProspective StudiesStatistics, NonparametricTreatment OutcomeUnited StatesViral LoadYoung AdultConceptsHuman immunodeficiency virus-infected adolescentsSuboptimal virologic responsePoor virologic responseVirologic responseActive antiretroviral therapyAntiretroviral therapyVirologic suppressionMultivariable logistic regression modelDual antiretroviral therapyInitiation of HAARTSuboptimal antiretroviral therapyAge-specific interventionsAcademic medical centerLogistic regression modelsCohort studyLymphocyte countViral loadEcho findingsAdequate adherenceTherapeutic failureBiopsychosocial predictorsHAARTMedical CenterAdolescent careConsecutive visits
2008
Simple Adherence Assessments to Predict Virologic Failure among HIV-Infected Adults with Discordant Immunologic and Clinical Responses to Antiretroviral Therapy
Goldman JD, Cantrell RA, Mulenga LB, Tambatamba BC, Reid SE, Levy JW, Limbada M, Taylor A, Saag MS, Vermund SH, Stringer JS, H. BH. Simple Adherence Assessments to Predict Virologic Failure among HIV-Infected Adults with Discordant Immunologic and Clinical Responses to Antiretroviral Therapy. AIDS Research And Human Retroviruses 2008, 24: 1031-1035. PMID: 18724803, PMCID: PMC2747786, DOI: 10.1089/aid.2008.0035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Retroviral AgentsFemaleHIV InfectionsHumansMaleProspective StudiesTreatment RefusalViremiaZambiaConceptsMedication possession ratioVirologic failureOptimal adherenceSuboptimal adherenceTreatment failurePoor adherenceLow medication possession ratioDetectable HIV viremiaProportion of patientsSubset of patientsViral load measurementsART initiationHIV viremiaAntiretroviral therapyDetectable viremiaClinical responseDrug adherencePossession ratioMedian timeMissed doseImmunologic responseTreatment courseAdherence assessmentCopies/PatientsDoes douching increase risk for sexually transmitted infections? A prospective study in high-risk adolescents
Tsai CS, Shepherd BE, Vermund SH. Does douching increase risk for sexually transmitted infections? A prospective study in high-risk adolescents. American Journal Of Obstetrics And Gynecology 2008, 200: 38.e1-38.e8. PMID: 18667177, PMCID: PMC3199592, DOI: 10.1016/j.ajog.2008.06.026.Peer-Reviewed Original ResearchConceptsHazard ratioCox proportional hazards modelIncidence of STIsProportional hazards modelAdjusted hazardIncident STIsProspective studyHigh-risk adolescentsHuman immunodeficiencySTI riskIncrease riskHazards modelNext visitSTIsVisitsDouchersFemale adolescentsDouchingAdolescentsInfectionRiskImmunodeficiencyIncidence
2005
Treatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults
Modjarrad K, Zulu I, Redden DT, Njobvu L, Lane HC, Bentwich Z, Vermund SH. Treatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults. The Journal Of Infectious Diseases 2005, 192: 1277-1283. PMID: 16136473, PMCID: PMC2730764, DOI: 10.1086/444543.Peer-Reviewed Original ResearchConceptsHIV-1 RNAViral loadPlasma concentrationsAntihelminthic treatmentCopies/Helminth infectionsIntestinal helminthsHigh pretreatment viral loadMedian baseline viral loadPretreatment viral loadBaseline viral loadDysfunctional immune responseIntestinal helminth infectionsHuman immunodeficiency virusMean viral loadCopies/mLHigher helminth burdensPosttreatment visitAsymptomatic adultsImmunodeficiency virusProspective studyZambian adultsUninfected groupHIV-1Immune response
2004
Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings
Stringer J, Sinkala M, Goldenberg RL, Kumwenda R, Acosta EP, Aldrovandi GM, Stout JP, Vermund SH. Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings. AIDS 2004, 18: 939-943. PMID: 15060442, PMCID: PMC2745979, DOI: 10.1097/00002030-200404090-00012.Peer-Reviewed Original ResearchConceptsChild HIV transmissionUnknown HIV serostatusHIV serostatusHIV transmissionPreliminary efficacyLabour wardHIV DNA polymerase chain reactionSingle-dose nevirapinePrevention of motherProspective cohort studyEvidence of infectionHigh-prevalence settingsWeeks of lifeNevirapine administrationNevirapine coverageChild transmissionCohort studyComparison cohortAdherence ratesPrevalence settingsPolymerase chain reactionCord bloodDNA polymerase chain reactionHIVInfant specimens
2003
Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine
Stringer J, Sinkala M, Chapman V, Acosta EP, Aldrovandi GM, Mudenda V, Stout JP, Goldenberg RL, Kumwenda R, Vermund SH. Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine. AIDS 2003, 17: 1659-1665. PMID: 12853748, PMCID: PMC2745973, DOI: 10.1097/00002030-200307250-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBreast FeedingDrug Administration ScheduleFemaleHIV InfectionsHIV SeropositivityHumansInfant, NewbornInfectious Disease Transmission, VerticalLabor, ObstetricNevirapineObstetric Labor ComplicationsPregnancyPregnancy Complications, InfectiousProspective StudiesReverse Transcriptase InhibitorsRisk FactorsTime FactorsConceptsPerinatal HIV transmissionHIV transmissionInfant HIV infection statusNeonatal single-dose nevirapineMaternal drug doseSingle-dose nevirapineHIV infection statusProspective cohort studyPerinatal transmission rateOnset of laborMain outcome measuresMean drug concentrationWeeks of lifeRisk of transmissionNVP levelsNVP prophylaxisNVP syrupObstetrical clinicPerinatal transmissionCohort studyOral doseViral loadPregnant womenPolymerase chain reactionRisk factorsComparison of Two Strategies for Administering Nevirapine to Prevent Perinatal HIV Transmission in High-Prevalence, Resource-Poor Settings
Stringer JS, Sinkala M, Stout JP, Goldenberg RL, Acosta EP, Chapman V, Kumwenda-Phiri R, Vermund SH. Comparison of Two Strategies for Administering Nevirapine to Prevent Perinatal HIV Transmission in High-Prevalence, Resource-Poor Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 32: 506-513. PMID: 12679702, PMCID: PMC2745994, DOI: 10.1097/00126334-200304150-00007.Peer-Reviewed Original ResearchConceptsHigh-prevalence settingsClinic AClinic BVCT servicesPrevent Perinatal HIV TransmissionPerinatal HIV acquisitionPerinatal HIV preventionPerinatal HIV transmissionKnowledge of serostatusResource-poor settingsNevirapine therapyNVP therapyHIV acquisitionHIV testingHIV statusHIV transmissionPregnant womenCord bloodHIV preventionHigh prevalenceInfant deathUniversal therapyClinicTherapyMaternal reports