2024
Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study
Chaila M, Mcleod D, Vermund S, Mbolongwe-Thornicroft M, Mbewe M, Mubekapi-Musadaidzwa C, Harper A, Schaap A, Floyd S, Hoddinott G, Hayes R, Fidler S, Ayles H, Shanaube K, Team O. Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study. PLOS ONE 2024, 19: e0266573. PMID: 38363733, PMCID: PMC10871489, DOI: 10.1371/journal.pone.0266573.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildHIV InfectionsHumansMass ScreeningPredictive Value of TestsSouth AfricaZambiaConceptsScreening toolUniversal testingCommunity HIV-care providersCombination HIV prevention packageHIV-care providersHIV-positiveHIV prevention packageRapid HIV testingHIV test resultsRapid HIV test resultsHistory of hospital admissionIdentification of adolescentsPopART interventionUndiagnosed HIVHIV testingPrevention packageDoor-to-doorPoor healthHIV interventionsCommunity settingsConsented adolescentsHospital admissionSelf-reportSouth AfricaPopART
2014
HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm B
2011
Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India
Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, Nagwanshi CA, Joshi SN, Jenkins CA, Shepherd BE, Kelkar RS, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India. International Journal Of Cancer 2011, 130: 234-240. PMID: 21387289, PMCID: PMC3516675, DOI: 10.1002/ijc.25971.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultCervix UteriColposcopyCross-Sectional StudiesCytodiagnosisDNA, ViralFemaleHIVHIV InfectionsHumansIndiaMass ScreeningPapanicolaou TestPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsCervical cytologyHigh-grade squamous intraepithelial lesionsHigh-grade cervical neoplasiaNegative predictive value estimatesScreening testHPV-positive CIN2Atypical squamous cellsSquamous intraepithelial lesionsHuman immunodeficiency virusConventional cervical cytologyPredictive value estimatesSecondary prevention methodsNonpregnant HIVRigorous endpointsAntiretroviral therapyHIV/Intraepithelial lesionsCervical neoplasiaCervical cancerImmunodeficiency virusSquamous cellsHuman papillomavirusUndetermined significanceIntraepithelial cellsCare program
2009
Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project
Ding H, Wilson CM, Modjarrad K, McGwin G, Tang J, Vermund SH. Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project. JAMA Pediatrics 2009, 163: 1100-1105. PMID: 19996046, PMCID: PMC3739292, DOI: 10.1001/archpediatrics.2009.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChi-Square DistributionFemaleHIV InfectionsHumansInterviews as TopicLogistic ModelsMalePatient CompliancePredictive Value of TestsPrevalenceProspective StudiesStatistics, NonparametricTreatment OutcomeUnited StatesViral LoadYoung AdultConceptsHuman immunodeficiency virus-infected adolescentsSuboptimal virologic responsePoor virologic responseVirologic responseActive antiretroviral therapyAntiretroviral therapyVirologic suppressionMultivariable logistic regression modelDual antiretroviral therapyInitiation of HAARTSuboptimal antiretroviral therapyAge-specific interventionsAcademic medical centerLogistic regression modelsCohort studyLymphocyte countViral loadEcho findingsAdequate adherenceTherapeutic failureBiopsychosocial predictorsHAARTMedical CenterAdolescent careConsecutive visits
2005
Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting.
Modjarrad K, Zulu I, REDDEN DT, Njobvu L, FREEDMAN DO, VERMUND SH. Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting. American Journal Of Tropical Medicine And Hygiene 2005, 73: 777-82. PMID: 16222025, PMCID: PMC2749260, DOI: 10.4269/ajtmh.2005.73.777.Peer-Reviewed Original ResearchConceptsHIV-1-infected adultsIntestinal helminth infectionsHelminth infectionsUrban African settingIntestinal helminthsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Detrimental immunologic effectsRoutine HIV careAfrican settingHuman immunodeficiency virusLight-intensity infectionsHIV infection ratesVirus type 1HIV careImmunologic effectsConcomitant infectionImmunodeficiency virusPrior historyHelminth diagnosisAscaris lumbricoidesHelminth statusParasitologic dataInfection rateInfection
2004
Marginal validity of syndromic management for reproductive tract infections among pregnant women in Jamaica
Hylton-Kong T, Brathwaite AR, Del Rosario GR, Kristensen S, Kamara P, Jolly PE, Hook EW, Figueroa JP, Vermund SH. Marginal validity of syndromic management for reproductive tract infections among pregnant women in Jamaica. International Journal Of STD & AIDS 2004, 15: 371-375. PMID: 15186580, DOI: 10.1258/095646204774195209.Peer-Reviewed Original ResearchConceptsReproductive tract infectionsSyndromic managementPregnant womenAntenatal clinicTract infectionsSyndromic case management approachAntenatal care facilitiesHigh-risk womenAffordable diagnostic testsPositive predictive valueCase management approachAntenatal attendersClinical algorithmClinical careCare facilitiesPredictive valueJamaican womenDiagnostic testsLaboratory supportWomenClinicInfectionLow sensitivityCervicitisCandidiasis
2003
Utility of cervicography in HIV-infected and uninfected adolescents
Moscicki AB, Durako SJ, Ma Y, Darragh T, Vermund SH. Utility of cervicography in HIV-infected and uninfected adolescents. Journal Of Adolescent Health 2003, 32: 204-213. PMID: 12606114, DOI: 10.1016/s1054-139x(02)00461-5.Peer-Reviewed Original ResearchConceptsPositive predictive valuePap smearUninfected groupHigh-risk adolescent populationAdequate Pap smearsLow positive predictive valueRepeat Papanicolaou smearsSingle Pap smearVisit 6 monthsHIV-positive youthHIV-negative youthPositive cervigramHIV infectionCervical cancerProspective studyVisit 1Papanicolaou smearsUninfected adolescentsHIVPredictive valueTime of analysisAdolescent populationCervicography