Salome Charalambous
Associate Professor AdjunctCards
About
Research
Publications
2025
Hidden in Success: Gendered Patterns of Suboptimal Care Engagement Among TB Patients Who “Successfully” Completed Treatment in South Africa
Marino A, Arua E, de Vos L, Fiphaza K, Bezuidenhout D, Ngcelwane N, Charalambous S, Daniels J. Hidden in Success: Gendered Patterns of Suboptimal Care Engagement Among TB Patients Who “Successfully” Completed Treatment in South Africa. Clinical Infectious Diseases 2025, ciaf714. PMID: 41417651, DOI: 10.1093/cid/ciaf714.Peer-Reviewed Original ResearchCare engagementSuboptimal engagementGendered patternsOptimal health outcomesPatient-centered counselingTB patientsGender-stratified modelsGender-responsive interventionsLongitudinal trajectoriesTreatment successHIV-negative statusMedication refill dataLatent class mixed modelsRefill patternsHealth outcomesTrajectory class membershipRefill dataFlexible treatment strategiesLogistic regressionRefill behaviorClass 1Treatment completionSouth AfricaShorter regimensMixed modelsA study protocol to co-develop and evaluate interventions that strengthen healthcare resilience to extreme weather events in three African countries: the ASTRA study
Mabuto T, Orievulu K, Bond V, Simwinga M, Grapsa E, Khoza T, Khan-Gillmore S, Nzimande L, Craig M, Khagayi S, Chirwa T, Chiau R, Ossemane E, Hoffmann C, Seeley J, Kniveton D, Babashahi S, Rangunwala A, Mthembu N, Oberholzer C, Charalambous S, Iwuji C. A study protocol to co-develop and evaluate interventions that strengthen healthcare resilience to extreme weather events in three African countries: the ASTRA study. Frontiers In Climate 2025, 7: 1679392. DOI: 10.3389/fclim.2025.1679392.Peer-Reviewed Original ResearchHealth system resilienceBurden of HIVEconomic evaluationDelphi consensus processMiddle-income countriesBenefits of interventionsMixed-methods studyASTRA studyPrototype interventionHealth outcomesHealthcare systemExtreme weather eventsConsensus processEvidence-basedService deliveryVulnerable populationsEthnographic assessmentScoping interviewsAssessment of communityCo-creation workshopsCommunity engagementStudy protocolInterventionAfrican countriesCosts of inactionEvaluating the New TB Antigen-Based Skin Test to Diagnose TB Infection in South Africa
Sathar F, du Toit C, Chihota V, Eastop C, Ndjeka N, Motlhaoleng K, Hausler H, Mphahlele M, Radia K, Ntshiqa T, Hatherill M, Switala J, Charalambous S, Velen K. Evaluating the New TB Antigen-Based Skin Test to Diagnose TB Infection in South Africa. Tropical Medicine And Infectious Disease 2025, 10: 338. PMID: 41441576, PMCID: PMC12737664, DOI: 10.3390/tropicalmed10120338.Peer-Reviewed Original ResearchTB preventive treatmentTB infection testingTB infectionSkin testWorld Health OrganizationPatient-level barriersTB diagnosisAcceptance of testingPoint-of-care optionPrevalence of TB infectionDiagnosing TB infectionLevel barriersDiagnosis of childrenPositive immunological testsHealthcare workersPregnant womenTB contactTB diseaseHealth OrganizationPreventive treatmentSouth AfricaImmunological testsSituation analysisMycobacterium tuberculosisPoor sensitivityCorrection: Epidemiological factors associated with immunological resistance in household contacts exposed to active tuberculosis in South Africa: A logistic regression analysis
Maenetje N, Oladimeji M, Mlotshwa M, Price M, Hoft D, Lindan C, Wallis R, Charalambous S, Churchyard G, Edward V, Fiore-Gartland A, Shai J, Maenetje P. Correction: Epidemiological factors associated with immunological resistance in household contacts exposed to active tuberculosis in South Africa: A logistic regression analysis. PLOS ONE 2025, 20: e0337706. PMID: 41289202, PMCID: PMC12646424, DOI: 10.1371/journal.pone.0337706.Peer-Reviewed Original ResearchShesha, a WhatsApp Chatbot for Linking Household Contacts to Tuberculosis Treatment or Preventive Therapy in South Africa: Design and Development
Mudzengi D, Ntshiqa T, Hamada Y, Ndebele F, Mpanza T, Kyobutungi B, Williams C, Kennealy M, Rangaka M, Velen K, Charalambous S. Shesha, a WhatsApp Chatbot for Linking Household Contacts to Tuberculosis Treatment or Preventive Therapy in South Africa: Design and Development. JMIR Formative Research 2025, 9: e71793. PMID: 41232026, PMCID: PMC12614398, DOI: 10.2196/71793.Peer-Reviewed Original ResearchAcceptability and feasibility of a group intervention for long COVID in Johannesburg, South Africa: a mixed-method study
Ramachandran R, Sathar F, Mokome P, Mathabela N, Mahlase E, Charalambous S, Rachow A, Glover N, Ivanova O. Acceptability and feasibility of a group intervention for long COVID in Johannesburg, South Africa: a mixed-method study. Frontiers In Health Services 2025, 5: 1666387. PMID: 41245100, PMCID: PMC12611963, DOI: 10.3389/frhs.2025.1666387.Peer-Reviewed Original ResearchSelf-management programProvincial Tertiary HospitalCommunity levelMiddle-income countriesDeductive thematic analysisMixed-methods studyHigh-income countriesQuality of lifeLong COVIDPilot interventionHealthcare disparitiesRehabilitation programMultidisciplinary interventionGroup interventionHospital staffMental healthThematic analysisMixed-methods approachLong COVID symptomsResearch staffTertiary hospitalInterventionDescriptive analysisChronic symptomsParticipantsClimate change and tuberculosis: an analytical framework
Saunders M, Boccia D, Khan P, Goscé L, Gasparrini A, Clark R, Pescarini J, Charalambous S, Fekadu L, Dockhorn da Costa Johansen F, Vasilyeva I, Narendran G, Li T, Ndjeka N, White R, Houben R, Zignol M, Gebreselassie N, McQuaid C. Climate change and tuberculosis: an analytical framework. The Lancet Respiratory Medicine 2025 PMID: 41177169, PMCID: PMC7618504, DOI: 10.1016/s2213-2600(25)00329-7.Peer-Reviewed Original ResearchFrequency of tuberculosis symptoms at repeat visits amongst adults attending for HIV care in Gauteng province, South Africa
Ntshiqa T, Jawad S, Hanifa Y, Chihota V, Charalambous S, Ndlovu N, Churchyard G, Fielding K, Grant A. Frequency of tuberculosis symptoms at repeat visits amongst adults attending for HIV care in Gauteng province, South Africa. BMC Public Health 2025, 25: 3667. PMID: 41162943, PMCID: PMC12573808, DOI: 10.1186/s12889-025-24984-3.Peer-Reviewed Original ResearchConceptsHIV careAntiretroviral therapyXpert MTB/RIFNight sweatsTesting of symptomatic patientsWorld Health OrganizationRoutine HIV careProportion of patientsWeight lossTB screening toolPre-ARTSymptomatic patientsGauteng ProvinceTuberculosis symptomsCohort studyTB diagnosisTB testClinical encountersCurrent coughHIVPatientsCase findingTuberculosisParent studyCareThe effect of smart pillboxes on TB stigma among adults in a cluster-randomised TB treatment trial
Jennings L, Maraba N, Mukora R, Hippner P, Velen K, Orrell C, Charalambous S, Fielding K. The effect of smart pillboxes on TB stigma among adults in a cluster-randomised TB treatment trial. IJTLD OPEN 2025, 2: 583-589. PMID: 41089234, PMCID: PMC12517265, DOI: 10.5588/ijtldopen.25.0113.Peer-Reviewed Original ResearchTB stigmaPrimary health care facilitiesStandard of care armCluster randomised trialExperiences of stigmaHealth-seeking behaviorHealth care facilitiesStigma domainsStigma QuestionnaireInternalised stigmaCare armCare facilitiesElectronic pillboxStigmaTreatment adherenceStudy populationTB statusSub-analysisPillboxFollow-upQuestionnaireInterventionTreatment initiationPrevalenceAdultsUptake of a Case Management Intervention for Continuity of Human Immunodeficiency Virus Treatment Among Individuals Released From Incarceration Living With HIV in South Africa
Ndini P, Mabuto T, Charalambous S, Chimoyi L, Wahome E, Hoffmann C, Ndlovu N. Uptake of a Case Management Intervention for Continuity of Human Immunodeficiency Virus Treatment Among Individuals Released From Incarceration Living With HIV in South Africa. Journal Of Correctional Health Care 2025, 31: 318-326. PMID: 40991449, DOI: 10.1177/10783458251379408.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCorrectional facilitiesAntiretroviral therapyHuman immunodeficiency virus disclosureHuman immunodeficiency virus treatmentHuman immunodeficiency virus prevalenceSouth AfricaCase management interventionMultiple logistic regressionImmunodeficiency virusIncarcerationUninterrupted treatmentCross-sectional analysisTreatment continuationCase management sessionsObservational studyCase managementCase management strategiesSocial supportVirus treatmentLogistic regressionTherapyTreatmentAfricaManagement sessions