2009
Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study
Connally NP, Durante AJ, Yousey-Hindes KM, Meek JI, Nelson RS, Heimer R. Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study. American Journal Of Preventive Medicine 2009, 37: 201-206. PMID: 19595558, DOI: 10.1016/j.amepre.2009.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsCase-Control StudiesChildChild, PreschoolConnecticutEnvironment DesignEnvironmental ExposureFemaleHumansHygieneInfantLogistic ModelsLyme DiseaseMaleMatched-Pair AnalysisMiddle AgedPopulation SurveillanceProspective StudiesResidence CharacteristicsRisk FactorsSurveys and QuestionnairesTicksYoung AdultConceptsCase-control studyLyme diseaseDisease prevention initiativesConditional logistic regressionDisease prevention measuresErythema migransPotential confoundersRecreational exposureLogistic regressionProspective ageDiseaseCase onsetPrevention resultsPrevention measuresPersonal protectionRiskHoursConfoundersMigransTicksInfectionStudyConnecticut communitiesMonths
1999
Serologic testing of horses for granulocytic ehrlichiosis, using indirect fluorescent antibody staining and immunoblot analysis.
Magnarelli L, Van Andel A, Ijdo J, Heimer R, Fikrig E. Serologic testing of horses for granulocytic ehrlichiosis, using indirect fluorescent antibody staining and immunoblot analysis. American Journal Of Veterinary Research 1999, 60: 631-5. PMID: 10328436, DOI: 10.2460/ajvr.1999.60.05.631.Peer-Reviewed Original Research
1998
Reactivity of Human Sera to Different Strains of Granulocytic Ehrlichiae in Immunodiagnostic Assays
Magnarelli L, IJdo J, Dumler J, Heimer R, Fikrig E. Reactivity of Human Sera to Different Strains of Granulocytic Ehrlichiae in Immunodiagnostic Assays. The Journal Of Infectious Diseases 1998, 178: 1835-1838. PMID: 9815246, DOI: 10.1086/314516.Peer-Reviewed Original ResearchConceptsNCH-1 strainIndirect IFAHuman granulocytic ehrlichiosis (HGE) agentHuman granulocytic ehrlichiosisWestern blot analysisInfected neutrophilsPromyelocytic leukemia cellsHuman promyelocytic leukemia cellsAntibody detectionGranulocytic ehrlichiosisEhrlichia equiDifferent strainsHuman isolatesLeukemia cellsSerumImmunodiagnostic assaysBlot analysisGranulocytic ehrlichiaeIFA analysisHuman serumIFAEhrlichiaeAssaysSeropositivityPatientsDevelopment and duration of antibody response against Ehrlichia equi in horses.
Andel A, Magnarelli L, Heimer R, Wilson M. Development and duration of antibody response against Ehrlichia equi in horses. Journal Of The American Veterinary Medical Association 1998, 212: 1910-4. PMID: 9638192, DOI: 10.2460/javma.1998.212.12.1910.Peer-Reviewed Original ResearchA single tissue culture system for the propagation of the agents of the human ehrlichioses.
Heimer R, Tisdale D, Dawson J. A single tissue culture system for the propagation of the agents of the human ehrlichioses. American Journal Of Tropical Medicine And Hygiene 1998, 58: 812-5. PMID: 9660470, DOI: 10.4269/ajtmh.1998.58.812.Peer-Reviewed Original Research
1997
Propagation of granulocytic Ehrlichia spp. from human and equine sources in HL-60 cells induced to differentiate into functional granulocytes
Heimer R, Van Andel A, Wormser G, Wilson M. Propagation of granulocytic Ehrlichia spp. from human and equine sources in HL-60 cells induced to differentiate into functional granulocytes. Journal Of Clinical Microbiology 1997, 35: 923-927. PMID: 9157154, PMCID: PMC229702, DOI: 10.1128/jcm.35.4.923-927.1997.Peer-Reviewed Original ResearchConceptsHL-60 cellsEquine sourcesRDNA genePromyelocytic leukemia cell lineGranulocytic differentiationLeukemia cell linesHL-60 promyelocytic leukemia cell lineDNA sequencingNortheastern Unites StatesCell linesRetinoic acidSame pathogenFunctional granulocytesEhrlichia sppHuman sourcesCellsGenesSequencingDifferentiationSppPathogensEhrlichiaPCR
1986
Levels of thymidylate synthetase during normal culture growth of L1210 cells.
Cadman E, Heimer R. Levels of thymidylate synthetase during normal culture growth of L1210 cells. Cancer Research 1986, 46: 1195-8. PMID: 3943093.Peer-Reviewed Original Research
1985
Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil
Danhauser L, Heimer R, Cadman E. Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil. Cancer Chemotherapy And Pharmacology 1985, 15: 214-219. PMID: 3876889, DOI: 10.1007/bf00263888.Peer-Reviewed Original ResearchConceptsSequential methotrexateΜM methotrexateL1210 cellsSynergistic cell killingCultured L1210 cellsFolinic acidMTX pretreatmentMethotrexateL1210 cell growthAcid-precipitable materialHuman neoplasmsPresence of methotrexateFUraInhibitory effectElevated levelsEnhanced cytotoxicityCell killingCell fractionCytotoxicityDUrd incorporationInhibitionThymidylate synthetaseCell growthThymidylate synthesisCultured cells
1983
Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine
Heimer R, Goldberg D, Cadman E. Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine. Biochemical Pharmacology 1983, 32: 199-206. PMID: 6870949, DOI: 10.1016/0006-2952(83)90544-0.Peer-Reviewed Original Research
1981
Analysis of the thymidylate synthetase ternary complex by high-performance liquid steric exclusion chromatography
Heimer R, Cadman E. Analysis of the thymidylate synthetase ternary complex by high-performance liquid steric exclusion chromatography. Analytical Biochemistry 1981, 118: 322-327. PMID: 7337229, DOI: 10.1016/0003-2697(81)90589-3.Peer-Reviewed Original ResearchEffect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity
Cadman E, Benz C, Heimer R, O'Shaughnessy J. Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity. Biochemical Pharmacology 1981, 30: 2469-2472. PMID: 21043247, DOI: 10.1016/0006-2952(81)90343-9.Peer-Reviewed Original ResearchConceptsSynergistic cytotoxicityEffect of methotrexateActivity of methotrexatePurine synthesis inhibitorsMethotrexate pretreatmentPurine synthesisControl levelsIntracellular elevationL-alanosineIntracellular accumulationGlutamine antagonistMethotrexateL1210 cellsSynthesis inhibitorInhibitorsCytotoxicityDe novo purineL-norleucineMetabolismAntagonistThe influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Cadman E, Heimer R, Benz C. The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. Journal Of Biological Chemistry 1981, 256: 1695-1704. PMID: 6161926, DOI: 10.1016/s0021-9258(19)69863-7.Peer-Reviewed Original ResearchConceptsMethotrexate pretreatmentConversion of FUraAddition of leucovorinSynergistic antitumor activityAbility of methotrexateTimes control valuesL1210 cellsEnhancement of intracellularSynergistic cell killingSoft agar cloningMethotrexate treatmentAntipurine effectMethotrexateConcentrations of methotrexateMaximal inhibitionControl valuesIntracellular methotrexateFUraInhibitory effectAntitumor activityExact mechanismIntracellular accumulationAgar cloningSimilar elevationsMicroM methotrexate
1979
Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism
Cadman E, Heimer R, Davis L. Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism. Science 1979, 205: 1135-1137. PMID: 472732, DOI: 10.1126/science.472732.Peer-Reviewed Original Research
1978
Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells.
Cadman E, Eiferman F, Heimer R, Davis L. Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells. Cancer Research 1978, 38: 4610-7. PMID: 82479.Peer-Reviewed Original Research