1992
RNA-directed actions of 5-fluorouridine in hemin stimulated K-562 erythroleukemia cells.
Heimer R, Sartorelli A. RNA-directed actions of 5-fluorouridine in hemin stimulated K-562 erythroleukemia cells. Cancer Biochemistry Biophysics 1992, 12: 221-39. PMID: 1423209.Peer-Reviewed Original Research
1989
RNA polymerase II transcripts as targets for 5-fluorouridine cytotoxicity: antagonism of 5-fluorouridine actions by α-amanitin
Heimer R, Sartorelli A. RNA polymerase II transcripts as targets for 5-fluorouridine cytotoxicity: antagonism of 5-fluorouridine actions by α-amanitin. Cancer Chemotherapy And Pharmacology 1989, 24: 80-86. PMID: 2731315, DOI: 10.1007/bf00263125.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAmanitinsCell DivisionCell Membrane PermeabilityChromatography, AffinityElectrophoresis, Agar GelHumansLeukemia, Erythroblastic, AcuteLysophosphatidylcholinesNucleic Acid HybridizationRNA Polymerase IIRNA PrecursorsRNA, MessengerTranscription, GeneticTumor Cells, CulturedTumor Stem Cell AssayUridine
1985
Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil
Danhauser L, Heimer R, Cadman E. Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil. Cancer Chemotherapy And Pharmacology 1985, 15: 214-219. PMID: 3876889, DOI: 10.1007/bf00263888.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell SurvivalDNA ReplicationDrug InteractionsFluorouracilKineticsLeucovorinLeukemia L1210MethotrexateMiceThymidylate SynthaseTranscription, GeneticConceptsSequential methotrexateΜM methotrexateL1210 cellsSynergistic cell killingCultured L1210 cellsFolinic acidMTX pretreatmentMethotrexateL1210 cell growthAcid-precipitable materialHuman neoplasmsPresence of methotrexateFUraInhibitory effectElevated levelsEnhanced cytotoxicityCell killingCell fractionCytotoxicityDUrd incorporationInhibitionThymidylate synthetaseCell growthThymidylate synthesisCultured cells