2023
CAXII inhibitors: Potential sensitizers for immune checkpoint inhibitors in HCC treatment
Han R, Li J, Hony J, Xiao Z, wang J, Yao M, Liang S, Lu L. CAXII inhibitors: Potential sensitizers for immune checkpoint inhibitors in HCC treatment. Frontiers In Immunology 2023, 14: 1052657. PMID: 37006233, PMCID: PMC10061011, DOI: 10.3389/fimmu.2023.1052657.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsC motif chemokine ligand 8Hepatocellular carcinomaCheckpoint inhibitorsDeath ligand 1 (PD-L1) immunotherapyCell death protein 1Treatment of HCCDeath protein 1Chemokine ligand 8Function of monocytesTumor immunosuppression microenvironmentClinical benefitCombination therapyImmunosuppression microenvironmentLethal malignancyTherapeutic effectEffective treatmentHCC treatmentAdvanced stageProtein 1Ligand 8ImmunotherapyTreatmentXII inhibitorsAnticancer drugs
2016
Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer
Deloria AJ, Höflmayer D, Kienzl P, Łopatecka J, Sampl S, Klimpfinger M, Braunschmid T, Bastian F, Lu L, Marian B, Stättner S, Holzmann K. Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer. Oncotarget 2016, 5: 73800-73816. PMID: 27650542, PMCID: PMC5342015, DOI: 10.18632/oncotarget.12070.Peer-Reviewed Original ResearchConceptsColorectal cancerEpithelial-mesenchymal transitionPrognostic valueNon-neoplastic colorectal epitheliumPrognosis of CRCFavorable overall survivalHuman colorectal cancerRole of ESRP1Overall survivalCRC casesPathological stageCRC cellsPrognostic stratificationFavorable outcomeTumor stagingClinical dataTCGA cohortColorectal epitheliumTumor progressionMicrosatellite instabilityMicrosatellite stabilityTumor cellsEarly detectionProtein 1Tissue expression