Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers
Tan H, Wang Q, Wang A, Ye Y, Feng N, Feng X, Lu L, Au W, Zheng Y, Xia Z. Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers. Toxicology And Applied Pharmacology 2010, 247: 198-203. PMID: 20637790, DOI: 10.1016/j.taap.2010.07.006.Peer-Reviewed Original ResearchConceptsGenotypes of GSTM1Higher MN frequencyMicronucleus frequencyChromosomal damageNon-exposed healthy individualsMN frequencyPolymorphisms of GSTM1Lower micronucleus frequencyBD exposure levelsPeripheral lymphocytesHealthy individualsMEH polymorphismsMetabolic polymorphismsBD exposureGSTM1CYP2E1Exposure levelsHigh groupCBMN assayLow exposureHuman carcinogenPCR-RFLPChromosome damageIntermediate groupPresent study