2023
Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids
Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Pollitt K, Khan S, Johnson C. Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environmental Science And Technology 2023, 57: 21016-21028. PMID: 38064429, DOI: 10.1021/acs.est.3c04844.Peer-Reviewed Original ResearchConceptsColorectal cancerFatty acid β-oxidationCell linesSW48 cell linesSynthesis of proteinsProgression of CRCMigration phenotypeCRC cell linesEpithelial-mesenchymal transitionThree-dimensional spheroidsMetabolic pathwaysN-cadherinΒ-oxidationMechanism of actionNovel insightsE-cadherinBiological techniquesPromotes MigrationColorectal cancer spheroidsMigration assaysMetabolic profilingKRAS G12APerfluorooctanoic acidPersistent environmental contaminantsMetabolic profile
2018
Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats
Di QN, Cao WX, Xu R, Lu L, Xu Q, Wang XB. Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats. Toxicology And Applied Pharmacology 2018, 348: 67-75. PMID: 29641977, DOI: 10.1016/j.taap.2018.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsCarnitine O-PalmitoyltransferaseEndocrine DisruptorsEndometrial HyperplasiaEndometriumEnergy MetabolismEstradiolFatty AcidsFemaleGlutathioneLiverMalondialdehydeMetabolomicsOogenesisOvaryOxidation-ReductionPhenolsPPAR gammaRats, Sprague-DawleyReproductionRisk AssessmentSuperoxide DismutaseConceptsFemale reproductive toxicityReproductive toxicityFemale ratsCarnitine palmitoyltransferase IEnergy homeostasisSerum 17β-estradiol levelsChronic low-dose exposurePeroxisome proliferator-activated receptor gammaImpaired fatty acid oxidationProliferator-activated receptor gammaReproductive systemHigh-dose exposureLow-dose exposureHuman exposure scenariosNP exposureFatty acid oxidationKey reproductive tissuesEndometrium hyperplasiaL-carnitineReceptor gammaPotential biomarkersComprehensive metabolomic studyEndocrine-disrupting chemicalsMetabolic profileDevelopmental toxicity