2018
Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats
Di QN, Cao WX, Xu R, Lu L, Xu Q, Wang XB. Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats. Toxicology And Applied Pharmacology 2018, 348: 67-75. PMID: 29641977, DOI: 10.1016/j.taap.2018.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsCarnitine O-PalmitoyltransferaseEndocrine DisruptorsEndometrial HyperplasiaEndometriumEnergy MetabolismEstradiolFatty AcidsFemaleGlutathioneLiverMalondialdehydeMetabolomicsOogenesisOvaryOxidation-ReductionPhenolsPPAR gammaRats, Sprague-DawleyReproductionRisk AssessmentSuperoxide DismutaseConceptsFemale reproductive toxicityReproductive toxicityFemale ratsCarnitine palmitoyltransferase IEnergy homeostasisSerum 17β-estradiol levelsChronic low-dose exposurePeroxisome proliferator-activated receptor gammaImpaired fatty acid oxidationProliferator-activated receptor gammaReproductive systemHigh-dose exposureLow-dose exposureHuman exposure scenariosNP exposureFatty acid oxidationKey reproductive tissuesEndometrium hyperplasiaL-carnitineReceptor gammaPotential biomarkersComprehensive metabolomic studyEndocrine-disrupting chemicalsMetabolic profileDevelopmental toxicity
2017
Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats
Gao HT, Xu R, Cao WX, Qian LL, Wang M, Lu L, Xu Q, Yu SQ. Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food And Chemical Toxicology 2017, 101: 94-104. PMID: 28089693, DOI: 10.1016/j.fct.2017.01.011.Peer-Reviewed Original ResearchConceptsLong-term low-dose exposureMale reproductive toxicityLow-dose exposureReproductive toxicityMale rat reproductive systemSteroidogenic proteinsRat reproductive systemApoptosis-related proteinsPathological examinationRat testicular cellsMale ratsTesticular testosteroneCell cycle progressionRatsTesticular cellsReproductive systemTestosteroneToxicityExposureCycle progressionCell cycleIntegrated exposureButyl benzylToxicity evaluationMixP