2012
Favorable outcome associated with an IGF-1 ligand signature in breast cancer
Mu L, Tuck D, Katsaros D, Lu L, Schulz V, Perincheri S, Menato G, Scarampi L, Harris L, Yu H. Favorable outcome associated with an IGF-1 ligand signature in breast cancer. Breast Cancer Research And Treatment 2012, 133: 321-331. PMID: 22297468, DOI: 10.1007/s10549-012-1952-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularCohort StudiesDisease-Free SurvivalFemaleGene ExpressionGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IKaplan-Meier EstimateLigandsMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalOligonucleotide Array Sequence AnalysisPrognosisReceptor, IGF Type 1Young AdultConceptsIGF-1 ligandBreast cancerFavorable outcomeInsulin-like growth factor (IGF) axisActivation signaturePrimary breast cancerGrowth factor axisPredictors of responseHuman breast cancerPathway analysisUpregulation of pathwaysBetter prognosisIGF axisPrognostic valueReceptor levelsLevels of mRNAFactor axisIGF ligandsIngenuity softwarePathway activation scoresCancerLigand levelsActivation scoresHigh groupProliferation pathways
2010
Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers
Tan H, Wang Q, Wang A, Ye Y, Feng N, Feng X, Lu L, Au W, Zheng Y, Xia Z. Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers. Toxicology And Applied Pharmacology 2010, 247: 198-203. PMID: 20637790, DOI: 10.1016/j.taap.2010.07.006.Peer-Reviewed Original ResearchConceptsGenotypes of GSTM1Higher MN frequencyMicronucleus frequencyChromosomal damageNon-exposed healthy individualsMN frequencyPolymorphisms of GSTM1Lower micronucleus frequencyBD exposure levelsPeripheral lymphocytesHealthy individualsMEH polymorphismsMetabolic polymorphismsBD exposureGSTM1CYP2E1Exposure levelsHigh groupCBMN assayLow exposureHuman carcinogenPCR-RFLPChromosome damageIntermediate groupPresent study