Featured Publications
The Real‐World Ethics of Adaptive‐Design Clinical Trials
Bothwell LE, Kesselheim AS. The Real‐World Ethics of Adaptive‐Design Clinical Trials. The Hastings Center Report 2017, 47: 27-37. PMID: 29171051, DOI: 10.1002/hast.783.Peer-Reviewed Original ResearchConceptsClinical equipoisePrimary ethical concernsMedical researchEthical approachEthical argumentsEthical justificationTrial control armEthical concernsEthicsAdaptive design clinical trialsTheoretical equipoiseCritical principlesEquipoiseAllocation of subjectsInferior treatmentProduct sponsorsArgumentCritical assessmentConventional RCTsAdditional concernsUseful standardActual trialAdaptive trialsJustificationClaims
2019
Bioethical Issues in Pharmacoepidemiologic Research
Bothwell L, Richterich A, Greene J. Bioethical Issues in Pharmacoepidemiologic Research. 2019, 772-791. DOI: 10.1002/9781119413431.ch31.Peer-Reviewed Original ResearchBioethical issuesField of bioethicsTechnologies of surveillancePharmacoepidemiologic researchSociological perspectiveEthical approachSociological dimensionsBioethical principlesField of pharmacoepidemiologyNational variationsInternational perspectivePerspectiveChapter brieflyBioethicsIssuesResearchMedical therapeuticsAttentionRecent yearsCommonalitiesPrinciplesData analysisRecent developmentsBrieflyDimensions