2022
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Eyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil. ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.Peer-Reviewed Original ResearchConceptsInfection riskSignificant global public health burdenCommunity-based cohort studyGlobal public health burdenPublic health burdenAgents of leptospirosisExposure of interestYears of agePublic health interventionsHigh-risk communitiesJoint spatial modellingZoonotic spilloverCohort studyHuman infection riskMale genderSerological evidenceHealth burdenLeptospira infectionLeptospiral infectionInfection rateHealth interventionsEco-epidemiological studiesHealth surveillanceFundação de Amparo à PesquisaOswaldo Cruz Foundation
2020
Effects of Accounting for Interval-Censored Antibody Titer Decay on Seroincidence in a Longitudinal Cohort Study of Leptospirosis
Bonner K, Cruz JS, Sacramento GA, de Oliveira D, Nery N, Carvalho M, Costa F, Childs JE, Ko AI, Diggle PJ. Effects of Accounting for Interval-Censored Antibody Titer Decay on Seroincidence in a Longitudinal Cohort Study of Leptospirosis. American Journal Of Epidemiology 2020, 190: 893-899. PMID: 33274738, PMCID: PMC8096484, DOI: 10.1093/aje/kwaa253.Peer-Reviewed Original ResearchConceptsLongitudinal cohort studyCohort studyMicroscopic agglutination test titersAgglutination test titersHigh transmission settingsPoint-source exposureSeroincidence ratesEstimates of infectionRisk factorsTest titersReported casesEpidemiologic implicationsInfection rateMean infection rateSerological samplesSerological assaysLeptospirosis casesInfectionArboviral diseasesTiter dilutionsSeroincidenceSource exposureLeptospirosisSample size estimationInterval