2013
Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis
Silvera S, Mayne ST, Gammon MD, Vaughan TL, Chow WH, Dubin JA, Dubrow R, Stanford JL, West AB, Rotterdam H, Blot WJ, Risch HA. Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis. Annals Of Epidemiology 2013, 24: 50-57. PMID: 24239095, PMCID: PMC4006990, DOI: 10.1016/j.annepidem.2013.10.009.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellCase-Control StudiesConnecticutDietEsophageal NeoplasmsFeeding BehaviorFemaleGastroesophageal RefluxHumansIncidenceLife StyleLogistic ModelsMaleMiddle AgedNew JerseyRisk FactorsStatistics as TopicStomach NeoplasmsSurveys and QuestionnairesWashingtonYoung AdultConceptsImportant risk stratification factorRisk stratification factorsSquamous cell carcinomaRisk of subtypesGastric cardiaRisk factorsCell carcinomaGastric cancerStratification factorsPopulation-based case-control studyGastroesophageal reflux disease symptomsEsophageal squamous cell carcinomaGastroesophageal reflux diseaseCase-control studyInteraction of dietReflux diseaseLifestyle factorsWine intakeDietary factorsCancer sitesMedical factorsGastric sitesNoncitrus fruitClassification tree analysisCancer subtypes
2012
Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations
Palmer AJ, Lochhead P, Hold GL, Rabkin CS, Chow WH, Lissowska J, Vaughan TL, Berry S, Gammon M, Risch H, El-Omar EM. Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations. European Journal Of Cancer Prevention 2012, 21: 541-544. PMID: 22805490, PMCID: PMC3460062, DOI: 10.1097/cej.0b013e3283529b79.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesEsophageal NeoplasmsFemaleGastrointestinal NeoplasmsGenetic Predisposition to DiseaseHumansMaleMembrane Transport ProteinsMucin-1Phosphoinositide Phospholipase CPolandPolymorphism, Single NucleotidePrognosisRisk FactorsUnited StatesWhite PeopleConceptsUpper gastrointestinal cancerOesophageal squamous cell cancerSquamous cell cancerGastrointestinal cancerCancer casesRisk of GCCaucasian populationCell cancerOdds ratioOesophageal squamous cell carcinomaSquamous cell carcinomaConfidence intervalsCase-control studyIntestinal histological typeGastric cancer casesHistological typeCell carcinomaSimilar associationGC casesChinese populationFirst studyCancerLarge genome-wide association studiesMUC1AdenocarcinomaThe importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
Lubin JH, Cook MB, Pandeya N, Vaughan TL, Abnet CC, Giffen C, Webb PM, Murray LJ, Casson AG, Risch HA, Ye W, Kamangar F, Bernstein L, Sharp L, Nyrén O, Gammon MD, Corley DA, Wu AH, Brown LM, Chow WH, Ward MH, Freedman ND, Whiteman DC. The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Cancer Epidemiology 2012, 36: 306-316. PMID: 22504051, PMCID: PMC3489030, DOI: 10.1016/j.canep.2012.03.001.Peer-Reviewed Original ResearchConceptsEsophagogastric junctional adenocarcinomaBody mass indexSquamous cell carcinomaEsophageal adenocarcinomaEsophageal Adenocarcinoma ConsortiumCigarette smokingAlcohol consumptionAcid refluxCell carcinomaBarrett's esophagusInverse associationEffect modificationYounger ageCigarettes/dayDrinks/dayExposure rateSignificant effect modificationCase-control studyTotal exposureHigh exposure rateEvaluated effect modificationJunctional adenocarcinomaMass indexSmoking effectsOdds ratio
2011
Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
Lochhead P, Ng MT, Hold GL, Rabkin CS, Vaughan TL, Gammon MD, Risch HA, Lissowska J, Mukhopadhya I, Chow WH, El-Omar EM. Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer. European Journal Of Cancer Prevention 2011, 20: 54-57. PMID: 21102338, PMCID: PMC3020097, DOI: 10.1097/cej.0b013e328341e320.Peer-Reviewed Original ResearchConceptsOesophageal cancerOdds ratioStudy populationCancer riskPopulation-based case-control studyUpper gastrointestinal cancer riskOesophageal squamous cell carcinomaGastrointestinal cancer riskWide association studies-identified single-nucleotide polymorphismsNoncardia gastric cancerSquamous cell carcinomaUpper gastrointestinal cancerCase-control studyColorectal cancer susceptibilitySecond study populationGastric cancer casesGastric cancer riskPotential confounding variablesFirst study populationCardia cancerCell carcinomaGastrointestinal cancerInverse associationCancer casesGastric cancer
2010
Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals
Lochhead P, Frank B, Hold GL, Rabkin CS, Ng MT, Vaughan TL, Risch HA, Gammon MD, Lissowska J, Weck MN, Raum E, Müller H, Illig T, Klopp N, Dawson A, McColl KE, Brenner H, Chow W, El–Omar E. Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals. Gastroenterology 2010, 140: 435-441. PMID: 21070776, PMCID: PMC3031760, DOI: 10.1053/j.gastro.2010.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAntigens, NeoplasmCarcinoma, Squamous CellCase-Control StudiesEsophageal NeoplasmsFemaleGastritis, AtrophicGastrointestinal NeoplasmsGenetic Predisposition to DiseaseGPI-Linked ProteinsHelicobacter InfectionsHelicobacter pyloriHumansMaleNeoplasm ProteinsPolymorphism, Single NucleotideRiskWhite PeopleConceptsChronic atrophic gastritisNoncardia gastric cancerUpper gastrointestinal cancerGastric cancer casesProstate stem cell antigen (PSCA) geneCancer casesGastric cancerAtrophic gastritisGastrointestinal cancerRs2294008 polymorphismWhite individualsRisk allelesHelicobacter pylori-infected subjectsPylori-infected subjectsPopulation-based studySquamous cell carcinomaGastric cancer patientsGastric cardia cancerCase-control studyEsophageal cancer casesDiffuse histologic typeAntigen geneProximal cancersGastric atrophyHistologic type
2008
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
Figueroa JD, Terry MB, Gammon MD, Vaughan TL, Risch HA, Zhang FF, Kleiner DE, Bennett WP, Howe CL, Dubrow R, Mayne ST, Fraumeni JF, Chow WH. Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression. Cancer Causes & Control 2008, 20: 361-368. PMID: 18989634, PMCID: PMC2726999, DOI: 10.1007/s10552-008-9250-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAnti-Inflammatory Agents, Non-SteroidalBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfidence IntervalsEsophageal NeoplasmsGastroesophageal RefluxHumansImmunohistochemistryLogistic ModelsMiddle AgedMulticenter Studies as TopicOdds RatioPopulation SurveillanceRisk FactorsSmokingStomach NeoplasmsTumor Suppressor Protein p53United StatesConceptsBody mass indexNon-steroidal anti-inflammatory drugsGastroesophageal reflux diseaseRisk factorsP53 overexpressionGastric cancerCigarette smokingReflux diseaseMass indexNon-steroidal anti-inflammatory drug useTumor subtypesPopulation-based case-control studyAnti-inflammatory drug useNon-cardia gastric adenocarcinomaGastro-esophageal reflux diseaseLarger body mass indexNon-cardia gastric cancerEsophageal squamous cell carcinomaTumor p53 overexpressionRisk factor profileSquamous cell carcinomaRisk of subtypesCase-control studyAnti-inflammatory drugsP53 protein overexpressionFood group intake and risk of subtypes of esophageal and gastric cancer
Silvera S, Mayne ST, Risch H, Gammon MD, Vaughan TL, Chow W, Dubrow R, Schoenberg JB, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF. Food group intake and risk of subtypes of esophageal and gastric cancer. International Journal Of Cancer 2008, 123: 852-860. PMID: 18537156, PMCID: PMC3008621, DOI: 10.1002/ijc.23544.Peer-Reviewed Original ResearchConceptsGastric cardia adenocarcinomaNoncardia gastric adenocarcinomaHigh-fat dairyFood group intakesCardia adenocarcinomaGastric adenocarcinomaEsophageal adenocarcinomaGroup intakesOdds ratioGastric cancerHigh intakePopulation-based case-control studyNon-cardia gastric adenocarcinomaEsophageal squamous cell carcinomaRed meatTotal meat intakeSquamous cell carcinomaTotal vegetable intakeRisk of subtypesEsophageal adenocarcinoma riskCase-control studyGastric cardiaAdenocarcinoma riskCell carcinomaRisk factors
2005
Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers
Trivers KF, de Roos AJ, Gammon MD, Vaughan TL, Risch HA, Olshan AF, Schoenberg JB, Mayne ST, Dubrow R, Stanford JL, Abrahamson P, Rotterdam H, West AB, Fraumeni JF, Chow WH. Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers. Clinical Gastroenterology And Hepatology 2005, 3: 225-230. PMID: 15765441, DOI: 10.1016/s1542-3565(04)00613-5.Peer-Reviewed Original ResearchConceptsBody mass indexEsophageal squamous cell carcinomaGastric cancerHazard ratioLonger survivalNonsteroidal anti-inflammatory drug usePopulation-based case-control studyAnti-inflammatory drug usePrediagnosis body mass indexAdjusted hazard ratioGastroesophageal reflux diseaseSquamous cell carcinomaConfidence intervalsGastric cancer survivalCase-control studyEsophageal adenocarcinoma patientsLocalized diseaseReflux diseaseMass indexAlcohol intakeCigarette smokingDecreased riskIncident casesAdenocarcinoma patientsCell carcinoma
2003
Population Attributable Risks of Esophageal and Gastric Cancers
Engel LS, Chow W, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, West AB, Blaser M, Blot WJ, Gail MH, Fraumeni JF. Population Attributable Risks of Esophageal and Gastric Cancers. Journal Of The National Cancer Institute 2003, 95: 1404-1413. PMID: 13130116, DOI: 10.1093/jnci/djg047.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAlcohol DrinkingBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfounding Factors, EpidemiologicEnzyme-Linked Immunosorbent AssayEsophageal NeoplasmsFeeding BehaviorFemaleFruitGastroesophageal RefluxHumansLife StyleMaleMiddle AgedNitritesObesityRisk AssessmentRisk FactorsSmokingStomach NeoplasmsStomach UlcerUnited StatesVegetablesConceptsCombined population attributable riskPopulation attributable riskNoncardia gastric adenocarcinomaEsophageal squamous cell carcinomaSquamous cell carcinomaGastric cardia adenocarcinomaBody mass indexGastric adenocarcinomaRisk factorsCell carcinomaCardia adenocarcinomaGastroesophageal refluxMass indexPylori infectionAttributable riskEsophageal adenocarcinomaGastric cancerVegetable consumptionMulticenter population-based case-control studyPopulation-based case-control studyPrevalence of smokingH. pylori infectionHelicobacter pylori infectionCase-control studyLow fruit
2001
Nutrient intake and risk of subtypes of esophageal and gastric cancer.
Mayne ST, Risch HA, Dubrow R, Chow WH, Gammon MD, Vaughan TL, Farrow DC, Schoenberg JB, Stanford JL, Ahsan H, West AB, Rotterdam H, Blot WJ, Fraumeni JF. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 1055-62. PMID: 11588131.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAge DistributionAgedCarcinoma, Squamous CellCase-Control StudiesConfidence IntervalsConnecticutDietEsophageal NeoplasmsFemaleHumansIncidenceMaleMiddle AgedNew JerseyOdds RatioPopulation SurveillanceReference ValuesRisk AssessmentRisk FactorsSex DistributionStomach NeoplasmsWashingtonConceptsNoncardia gastric cancerGastric cancerGastric cardiaNutrient intakeEsophageal adenocarcinomaOdds ratioHigh intakeTumor typesPopulation-based case-control studyVitamin C supplement useEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaRisk of adenocarcinomaSquamous cell carcinomaRisk of subtypesCase-control studyRisk of cancerPercentile of intakeSupplement useCell carcinomaDietary nitriteGastric adenocarcinomaRisk factorsDietary cholesterolIncidence rate
2000
Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer
Farrow D, Vaughan T, Sweeney C, Gammon M, Chow W, Risch H, Stanford J, Hansten P, Mayne S, Schoenberg J, Rotterdam H, Ahsan H, West A, Dubrow R, Fraumeni J, Blot W. Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer. Cancer Causes & Control 2000, 11: 231-238. PMID: 10782657, DOI: 10.1023/a:1008913828105.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseNon-cardia gastric adenocarcinomaEsophageal adenocarcinomaGERD symptomsReflux diseaseH2 blockersGastric adenocarcinomaGastric cancerLarge population-based case-control studyPopulation-based case-control studyPopulation-based tumor registryEsophageal squamous cell carcinomaPerson structured interviewRisk of esophagealSquamous cell carcinomaEsophageal adenocarcinoma riskH2-receptor antagonistsCase-control studyGastric cardia adenocarcinomaRandom digit dialingLong-term usersTumor RegistryAdenocarcinoma riskDaily symptomsCell carcinoma
1997
Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia
Gammon M, Ahsan H, Schoenberg J, West A, Rotterdam H, Niwa S, Blot W, Risch H, Dubrow R, Mayne S, Vaughan T, Stanford J, Farrow D, Chow W, Fraumeni J. Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia. Journal Of The National Cancer Institute 1997, 89: 1277-1284. PMID: 9293918, DOI: 10.1093/jnci/89.17.1277.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaGastric cardiaSquamous cell carcinomaCell carcinomaGastric adenocarcinomaRisk factorsTumor typesNoncardia gastric adenocarcinomaDuration of smokingCurrent cigarette smokersRisk of esophagealMajor risk factorCase-control studyGastric cardia adenocarcinomaEarly-stage carcinogenesisCigarette smokersHigher ORsControl subjectsIncidence rateSimilar ORsCardia adenocarcinomaEstimates of riskAdenocarcinomaCardiaSmoking
1993
Are Female Smokers at Higher Risk for Lung Cancer than Male Smokers?
Risch H, Howe G, Jain M, Burch J, Holowaty E, Miller A. Are Female Smokers at Higher Risk for Lung Cancer than Male Smokers? American Journal Of Epidemiology 1993, 138: 281-293. PMID: 8395141, DOI: 10.1093/oxfordjournals.aje.a116857.Peer-Reviewed Original ResearchConceptsLung cancerOdds ratioElevated riskGreater smoking cessationHigher elevated riskCase-control studyHigher odds ratioLife-style factorsArea of residenceHistologic groupingsMale smokersFemale smokersCigarette smokingSmoking cessationCancer casesHigh riskCigarette consumptionDetailed questioningLifelong historySmokersTobacco productsCancerDuration of timeMale-female differencesSmoking