2023
Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis
Fu Z, Brooks M, Irvin S, Jordan S, Aben K, Anton-Culver H, Bandera E, Beckmann M, Berchuck A, Brooks-Wilson A, Chang-Claude J, Cook L, Cramer D, Cushing-Haugen K, Doherty J, Ekici A, Fasching P, Fortner R, Gayther S, Gentry-Maharaj A, Giles G, Goode E, Goodman M, Group A, Harris H, Hein A, Kaaks R, Kiemeney L, Köbel M, Kotsopoulos J, Kotsopoulos J, Le N, Lee A, Matsuo K, McGuire V, McLaughlin J, Menon U, Milne R, Moysich K, Pearce C, Pike M, Qin B, Ramus S, Riggan M, Rothstein J, Schildkraut J, Sieh W, Sutphen R, Terry K, Thompson P, Titus L, van Altena A, White E, Whittemore A, Wu A, Zheng W, Ziogas A, Taylor S, Tang L, Songer T, Wentzensen N, Webb P, Risch H, Modugno F. Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis. Journal Of The National Cancer Institute 2023, 115: 539-551. PMID: 36688720, PMCID: PMC10165492, DOI: 10.1093/jnci/djad011.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerOral contraceptive useClear cell histotypeOvulatory yearsOvulation suppressionOdds ratioOvarian cancerContraceptive useNonmucinous epithelial ovarian cancerConfidence intervalsConsistent protective effectCase patientsMucinous tumorsPooled analysisProtective effectEOC riskControl participantsHistotypeCancerOvulationAssociationRegression modelsRiskYearsBeta coefficients
2020
Association Between Breastfeeding and Ovarian Cancer Risk
Babic A, Sasamoto N, Rosner BA, Tworoger SS, Jordan SJ, Risch HA, Harris HR, Rossing MA, Doherty JA, Fortner RT, Chang-Claude J, Goodman MT, Thompson PJ, Moysich KB, Ness RB, Kjaer SK, Jensen A, Schildkraut JM, Titus LJ, Cramer DW, Bandera EV, Qin B, Sieh W, McGuire V, Sutphen R, Pearce CL, Wu AH, Pike M, Webb PM, Modugno F, Terry KL. Association Between Breastfeeding and Ovarian Cancer Risk. JAMA Oncology 2020, 6: e200421. PMID: 32239218, PMCID: PMC7118668, DOI: 10.1001/jamaoncol.2020.0421.Peer-Reviewed Original ResearchConceptsOvarian cancer riskInvasive ovarian cancerEpithelial ovarian cancerOvarian cancerCancer riskLower riskOdds ratioLogistic regressionHigh-grade serous subtypeHistotype-specific associationsMultivariable logistic regressionCase-control studyOvarian Cancer Association ConsortiumPolytomous logistic regressionParous womenEndometrioid cancerModifiable factorsPooled analysisSerous subtypeMAIN OUTCOMEBreastfeedingMore monthsOverall associationLethal typeCancer
2017
Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies
Peres LC, Risch H, Terry KL, Webb PM, Goodman MT, Wu AH, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy ML, Cote ML, Funkhouser E, Moorman PG, Peters ES, Schwartz AG, Terry PD, Manichaikul A, Abbott SE, Camacho F, Jordan SJ, Nagle CM, Group A, Rossing M, Doherty J, Modugno F, Moysich K, Ness R, Berchuck A, Cook L, Le N, Brooks-Wilson A, Sieh W, Whittemore A, McGuire V, Rothstein J, Anton-Culver H, Ziogas A, Pearce C, Tseng C, Pike M, Schildkraut J, Consortium T. Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. International Journal Of Epidemiology 2017, 47: 460-472. PMID: 29211900, PMCID: PMC5913601, DOI: 10.1093/ije/dyx252.Peer-Reviewed Original ResearchConceptsAfrican American Cancer Epidemiology StudyRace/ethnicityCase-control studyOvarian Cancer Association ConsortiumOdds ratioLargest odds ratioRisk factorsFamily historyEOC riskFirst-degree family historyModifiable risk factorsMultivariable logistic regressionOvarian cancer incidenceRisk factor associationsCancer Epidemiology StudyEthnic differencesAsian/Pacific IslandersOvarian cancer etiologyBlack womenInvasive EOCPooled analysisEpidemiological characteristicsCancer incidenceOvarian cancerHigh prevalenceEpidemiologic factors that predict long-term survival following a diagnosis of epithelial ovarian cancer
Kim SJ, Rosen B, Fan I, Ivanova A, McLaughlin JR, Risch H, Narod SA, Kotsopoulos J. Epidemiologic factors that predict long-term survival following a diagnosis of epithelial ovarian cancer. British Journal Of Cancer 2017, 116: 964-971. PMID: 28208158, PMCID: PMC5379147, DOI: 10.1038/bjc.2017.35.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, Clear CellAdenocarcinoma, MucinousAdultAgedCanadaCystadenocarcinoma, SerousEndometrial NeoplasmsEpidemiologic FactorsFemaleFollow-Up StudiesHormone Replacement TherapyHumansMiddle AgedNeoplasm InvasivenessNeoplasm StagingOvarian NeoplasmsParityPregnancyPrognosisReproductive HistoryYoung AdultConceptsOvarian cancer-specific mortalityCancer-specific mortalityHormone replacement therapyRisk of deathEpithelial ovarian cancerOvarian cancerHazard ratioEpidemiologic factorsOvulatory cyclesOvarian cancer-specific deathOvarian cancer-specific survivalInvasive epithelial ovarian cancerBMI 5 yearsCancer-specific survivalCancer-specific deathOntario Cancer RegistryProportional hazards regressionConfidence intervalsBorderline significant associationOvarian cancer developmentLong-term survivalGreater cumulative numberHRT useCancer RegistryHistologic subtype
2012
Age at Last Birth in Relation to Risk of Endometrial Cancer: Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium
Setiawan VW, Pike MC, Karageorgi S, Deming SL, Anderson K, Bernstein L, Brinton LA, Cai H, Cerhan JR, Cozen W, Chen C, Doherty J, Freudenheim JL, Goodman MT, Hankinson SE, Lacey JV, Liang X, Lissowska J, Lu L, Lurie G, Mack T, Matsuno RK, McCann S, Moysich KB, Olson SH, Rastogi R, Rebbeck TR, Risch H, Robien K, Schairer C, Shu XO, Spurdle AB, Strom BL, Thompson PJ, Ursin G, Webb PM, Weiss NS, Wentzensen N, Xiang YB, Yang HP, Yu H, Horn-Ross PL, De Vivo I, Group T. Age at Last Birth in Relation to Risk of Endometrial Cancer: Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium. American Journal Of Epidemiology 2012, 176: 269-278. PMID: 22831825, PMCID: PMC3491967, DOI: 10.1093/aje/kws129.Peer-Reviewed Original ResearchConceptsEndometrial Cancer ConsortiumEndometrial cancerLast birthCancer ConsortiumLarge pooled analysisTumor histologic subtypeEndometrial cancer riskExogenous hormone useBody mass indexPooled odds ratioCase-control studyYears of ageHormone useHistologic subtypeMass indexPooled analysisRisk factorsEffect modificationOdds ratioDiagnosis groupsProtective associationCancer riskLower riskNumber of birthsOlder age
2002
Infertility, Fertility Drugs, and Ovarian Cancer: A Pooled Analysis of Case-Control Studies
Ness RB, Cramer DW, Goodman MT, Kjaer SK, Mallin K, Mosgaard BJ, Purdie DM, Risch HA, Vergona R, Wu AH. Infertility, Fertility Drugs, and Ovarian Cancer: A Pooled Analysis of Case-Control Studies. American Journal Of Epidemiology 2002, 155: 217-224. PMID: 11821246, DOI: 10.1093/aje/155.3.217.Peer-Reviewed Original ResearchConceptsFertility drug useCase-control studyOvarian cancerDrug useNulligravid womenFertility drugsBorderline serous tumorsOral contraception useMonths of useSubfertile womenHistologic subtypeSerous tumorsPooled analysisTubal ligationOdds ratioUnknown causeBiologic causesFamily historyCancer riskContraception useInfertilityCancerOverall riskConfidence intervalsWomen
2000
Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension
Eras J, Saftlas A, Triche E, Hsu C, Risch H, Bracken M. Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension. Epidemiology 2000, 11: 36-43. PMID: 10615841, DOI: 10.1097/00001648-200001000-00009.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaTransient hypertensionNulliparous womenDecreased riskMore abortionsPregnancy-related risk factorsHistory of abortionHypertensive disordersWeeks' gestationGestational ageSubsequent pregnancyPrenatal careRisk factorsObstetric practicePrior abortionMonths gestationPreeclampsiaHypertensionInduced abortionReproductive historyReferent groupProtective factorsGestationWomenAbortion
1996
Differences in Risk Factors for Epithelial Ovarian Cancer by Histologic Type
Risch H, Marrett L, Jain M, Howe G. Differences in Risk Factors for Epithelial Ovarian Cancer by Histologic Type. American Journal Of Epidemiology 1996, 144: 363-372. PMID: 8712193, DOI: 10.1093/oxfordjournals.aje.a008937.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerMucinous tumorsNonmucinous tumorsOvarian cancerHistologic typeOdds ratioPrimary epithelial ovarian cancerUnconditional logistic regression methodsInvasive serous cancerMucinous ovarian tumorsOral contraceptive useFull-term pregnancyRisk factor associationsCase-control studyOral contraceptivesSerous cancerEndometrioid cancerNoncontraceptive estrogensFat intakeInvasive cancerOvarian tumorsRisk factorsEpithelial tumorsReproductive factorsContraceptive use
1988
Lymphocyte micronuclei and sister chromatid exchanges among Canadian federal laboratory employees
Narod S, Neri L, Risch H, Raman S. Lymphocyte micronuclei and sister chromatid exchanges among Canadian federal laboratory employees. American Journal Of Industrial Medicine 1988, 14: 449-456. PMID: 3055975, DOI: 10.1002/ajim.4700140408.Peer-Reviewed Original Research
1983
EVENTS OF REPRODUCTIVE LIFE AND THE INCIDENCE OF EPITHELIAL OVARIAN CANCER
RISCH H, WEISS N, LYON J, DALING J, LIFF J. EVENTS OF REPRODUCTIVE LIFE AND THE INCIDENCE OF EPITHELIAL OVARIAN CANCER. American Journal Of Epidemiology 1983, 117: 128-139. PMID: 6681935, DOI: 10.1093/oxfordjournals.aje.a113523.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerOvarian cancerOral contraceptionInhibition of ovulationPituitary gonadotrophin secretionLack of associationThyroid medicationOral contraceptivesNoncontraceptive estrogensGonadotrophin secretionMedical historyRelative riskDiminished riskTotal doseYears of lactationCancerLogistic regression methodReproductive lifePregnancyMiscarriageRiskContraceptionRandom sampleWomenLactation