2005
Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study
Modi W, Scott K, Goedert J, Vlahov D, Buchbinder S, Detels R, Donfield S, O'Brien S, Winkler C. Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Genes & Immunity 2005, 6: 691-698. PMID: 16177829, DOI: 10.1038/sj.gene.6364258.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAllelesBlack or African AmericanChemokine CXCL12Chemokines, CXCChildCohort StudiesDisease ProgressionFemaleGene FrequencyHaplotypesHIV InfectionsHIV-1HumansLongitudinal StudiesMaleOdds RatioPolymorphism, Single NucleotideRisk FactorsSurvival AnalysisUnited StatesWhite PeopleConceptsSDF-1 geneCohort studySingle nucleotide polymorphismsAfrican AmericansOnly natural ligandSingle disease outcomesX4 HIV-1HIV-1 infectionAIDS Cohort StudyRisk of infectionMACS cohortDisease outcomeHIV-1Epidemiological studiesSDF-1Significant associationChemokine genesInfectionRs1801157Natural ligandProgressionHaplotype analysisCommon haplotypeCXCR4Cohort
2003
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans
Duggal P, An P, Beaty T, Strathdee S, Farzadegan H, Markham R, Johnson L, O'Brien S, Vlahov D, Winkler C. Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. Genes & Immunity 2003, 4: 245-250. PMID: 12761559, DOI: 10.1038/sj.gene.6363950.Peer-Reviewed Original ResearchConceptsPneumocystis carinii pneumoniaLate-stage HIV-1 infectionAfrican AmericansHIV-1 infectionMedian survival timeSIV infectionCarinii pneumoniaChemokine receptorsAIDS progressionPrimary coreceptorSurvival timeK polymorphismInitial infectionCXCR6Receptor allelesInfectionProgressionSingle nucleotide polymorphismsDeathK genotypesAIDSCoreceptorNucleotide polymorphismsGenetic influencesAllele frequencies
2002
HLA-Cw*04 and Hepatitis C Virus Persistence
Thio C, Gao X, Goedert J, Vlahov D, Nelson K, Hilgartner M, O'Brien S, Karacki P, Astemborski J, Carrington M, Thomas D. HLA-Cw*04 and Hepatitis C Virus Persistence. Journal Of Virology 2002, 76: 4792-4797. PMID: 11967296, PMCID: PMC136132, DOI: 10.1128/jvi.76.10.4792-4797.2002.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenHCV infectionViral persistenceAcute hepatitis C virus (HCV) infectionAssociation of HLAHepatitis C virus infectionHepatitis C virus (HCV) persistenceKiller immunoglobulin-like receptorsClass I human leukocyte antigenEarly host immune responseC virus infectionHCV RNA levelsNatural killer cellsImmunoglobulin-like receptorsCytolytic T cellsHost immune responsePolymorphic HLA genesHCV clearanceHCV persistenceKiller cellsViral clearanceLeukocyte antigenPx groupForeign antigensT cells
2001
Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data.
Ioannidis J, Rosenberg P, Goedert J, Ashton L, Benfield T, Buchbinder S, Coutinho R, Eugen-Olsen J, Gallart T, Katzenstein T, Kostrikis L, Kuipers H, Louie L, Mallal S, Margolick J, Martinez O, Meyer L, Michael N, Operskalski E, Pantaleo G, Rizzardi G, Schuitemaker H, Sheppard H, Stewart G, Theodorou I, Ullum H, Vicenzi E, Vlahov D, Wilkinson D, Workman C, Zagury J, O'Brien T. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Annals Of Internal Medicine 2001, 135: 782-95. PMID: 11694103, DOI: 10.7326/0003-4819-135-9-200111060-00008.Peer-Reviewed Original ResearchConceptsHIV-1 infectionCCR2-64I alleleHIV-1 RNA levelsHIV-1 disease progressionDevelopment of AIDSIndividual patient dataCCR5-Delta32Decreased riskDisease progressionProtective effectLower HIV-1 RNA levelsRNA levelsProspective cohort studyCase-control studyClear protective effectStrong protective effectChemokine receptor genesRandom-effects modelCCR2-64ICohort studyStudy entryCertain chemokinesAIDSInfectionProgressionEffect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS
Gao X, Nelson G, Karacki P, Martin M, Phair J, Kaslow R, Goedert J, Buchbinder S, Hoots K, Vlahov D, O'Brien S, Carrington M. Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS. New England Journal Of Medicine 2001, 344: 1668-1675. PMID: 11386265, DOI: 10.1056/nejm200105313442203.Peer-Reviewed Original ResearchConceptsRate of progressionHIV-1 infectionClass IHuman immunodeficiency virus type 1 (HIV-1) infectionDifferent peptide-binding specificitiesVirus type 1 infectionRisk of progressionT lymphocyte responsesInfluence of HLAType 1 infectionHIV-1 epitopesSubtypes of HLAHLA class IPeptide-binding specificityMHC class I moleculesAmino acid changesComplex class ISingle amino acid changeClass I moleculesReactive HLAImmunodeficiency syndromeRelated HLAPx groupCommon HLAHIV-1Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes
Thio C, Thomas D, Goedert J, Vlahov D, Nelson K, Hilgartner M, O’Brien S, Karacki P, Marti D, Astemborski J, Carrington M. Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes. The Journal Of Infectious Diseases 2001, 184: 16-21. PMID: 11398104, DOI: 10.1086/321005.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenClass II associationsViral clearanceClass II HLA typingClass II human leukocyte antigenHepatitis C virus clearanceHLA class II associationsCD4 T cell responsesT cell responsesClass II allelesHepatitis C virus outcomeHCV clearanceLeukocyte antigenVirus clearanceViral persistenceHLA typingImmune responseHomogeneous cohortCell responsesWhite subjectsDiverse cohortCohortClearanceVaried cohortsBlack subjects
2000
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10
Shin H, Winkler C, Stephens J, Bream J, Young H, Goedert J, O'Brien T, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien S, Smith M. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 14467-14472. PMID: 11121048, PMCID: PMC18942, DOI: 10.1073/pnas.97.26.14467.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1 replicationTranscription factor recognition sequencePromoter allelesLong-term nonprogressorsHIV-1 pathogenesisSingle nucleotide polymorphic variantsOnset of AIDSMacrophages/monocytesNuclear transcription factorSignificant genotype associationsIL10 promoter regionShort tandem repeat polymorphismsTranscription factorsPromoter regionRecognition sequenceIL10 productionInflammatory cytokinesCell cytokinesAIDS cohortC genotypeLymphoid cellsPromoter genotypeGenetic restrictionLymphocyte replicationInfluence of CCR5 promoter haplotypes on AIDS progression in African–Americans
An P, Martin M, Nelson G, Carrington M, Smith M, Gong K, Vlahov D, O'Brien S, Winkler C. Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans. AIDS 2000, 14: 2117-2122. PMID: 11061652, DOI: 10.1097/00002030-200009290-00007.Peer-Reviewed Original ResearchConceptsCCR5 promoter haplotypesAIDS progressionSurvival analysisAfrican AmericansNatural history cohort studyPromoter haplotypesRate of progressionPromoter variantsCohort studyCCR5 alleleRapid progressionCaucasian cohortProgressionCaucasiansComplete linkage disequilibriumCCR2AIDSUnidentified polymorphismsRacial groupsLinkage disequilibriumSeroconvertersCCR5CohortHaplotypesShort tandem repeat methodology for genotypic identification of single-person versus multi-person use of syringes
Shrestha S, Strathdee S, Brahmbhatt H, Farzadegan H, Vlahov D, Smith M. Short tandem repeat methodology for genotypic identification of single-person versus multi-person use of syringes. AIDS 2000, 14: 1507-1513. PMID: 10983637, DOI: 10.1097/00002030-200007280-00006.Peer-Reviewed Original Research
1999
Class II HLA Alleles and Hepatitis B Virus Persistence in African Americans
Thio C, Carrington M, Marti D, O'Brien S, Vlahov D, Nelson K, Astemborski J, Thomas D. Class II HLA Alleles and Hepatitis B Virus Persistence in African Americans. The Journal Of Infectious Diseases 1999, 179: 1004-1006. PMID: 10068598, DOI: 10.1086/314684.Peer-Reviewed Original ResearchConceptsHBV persistenceHBV infectionImmune responseClass II HLA typingHepatitis B virus (HBV) persistenceHepatitis B virus infectionClass II HLA allelesB virus infectionPersistent HBV infectionClass I associationsHost immune responseClass II allelesAfrican American cohortAntigen presentationVirus infectionHLA typingHLA allelesVirus persistenceTwo-locus haplotypesAmerican cohortThree-locus haplotypesClass IIHLA complexInfectionClass I
1998
Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5
Martin M, Dean M, Smith M, Winkler C, Gerrard B, Michael N, Lee B, Doms R, Margolick J, Buchbinder S, Goedert J, O'Brien T, Hilgartner M, Vlahov D, O'Brien S, Carrington M. Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5. Science 1998, 282: 1907-1911. PMID: 9836644, DOI: 10.1126/science.282.5395.1907.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAllelesChemokine CXCL12Chemokines, CXCCohort StudiesDisease ProgressionGenes, DominantGenes, RecessiveGenetic Predisposition to DiseaseGenotypeHaplotypesHeterozygoteHIV InfectionsHIV-1HomozygoteHumansPromoter Regions, GeneticProportional Hazards ModelsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CytokineRisk FactorsSurvival RateConceptsAIDS progressionCell-surface chemokine receptor moleculeCCR5 regulatory regionsChemokine receptor moleculesPercent of patientsAIDS disease progressionHIV-1 infectionCohort of peopleMacrophage-tropic strainsAIDS restriction genesDistinct regulatory influencesCCR2-64IPrincipal coreceptorImmunodeficiency syndromeCCR5-Delta32Genetic epidemiologic analysisDisease progressionHuman immunodeficiencySDF1-3'APromoter genotypeCCR5 geneInfected individualsEpidemiologic analysisHost factorsProgression
1992
Genetic Vulnerability to Drug Abuse: The D2 Dopamine Receptor Taq I B1 Restriction Fragment Length Polymorphism Appears More Frequently in Polysubstance Abusers
Smith S, O'Hara B, Persico A, Gorelick D, Newlin D, Vlahov D, Solomon L, Pickens R, Uhl G. Genetic Vulnerability to Drug Abuse: The D2 Dopamine Receptor Taq I B1 Restriction Fragment Length Polymorphism Appears More Frequently in Polysubstance Abusers. JAMA Psychiatry 1992, 49: 723-727. PMID: 1355337, DOI: 10.1001/archpsyc.1992.01820090051009.Peer-Reviewed Original Research