2019
Multivariate spatiotemporal modeling of drug- and alcohol-poisoning deaths in New York City, 2009–2014
Ransome Y, Subramanian SV, Duncan DT, Vlahov D, Warren J. Multivariate spatiotemporal modeling of drug- and alcohol-poisoning deaths in New York City, 2009–2014. Spatial And Spatio-temporal Epidemiology 2019, 32: 100306. PMID: 32007280, PMCID: PMC9996640, DOI: 10.1016/j.sste.2019.100306.Peer-Reviewed Original ResearchConceptsDrug-poisoning deathsMultivariate Poisson regression modelCurrent public health problemPublic health problemZip codesDrug overdose deathsCo-occurring epidemicsPublic health plannersPoisson regression modelsHigh prevalenceOverdose deathsHealth problemsHealth plannersHeavy drinkingDeathDrugsOutcomesRegression modelsPredictorsNew York CityIndividual-level predictorsPrevalenceYork City
2013
Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population
Manini A, Jacobs M, Vlahov D, Hurd Y. Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population. Journal Of Medical Toxicology 2013, 9: 148-154. PMID: 23318993, PMCID: PMC3648633, DOI: 10.1007/s13181-012-0286-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAmino Acid SubstitutionBenzodiazepinesCohort StudiesDrug OverdoseFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHeart ArrestHumansMaleNarcoticsPilot ProjectsPolymorphism, Single NucleotideProspective StudiesReceptors, Opioid, muRespiratory InsufficiencySeverity of Illness IndexSympathomimeticsUnited StatesConceptsAcute drug overdoseG variant alleleClinical severityVariant allelesEmergency departmentDrug overdoseSingle nucleotide polymorphismsConsecutive adult ED patientsHuman mu-opioid receptor geneReceptor single nucleotide polymorphismsWorse clinical severityAdult ED patientsObservational cohort studyUrban teaching hospitalMu-opioid receptor geneAbove single nucleotide polymorphismsCohort studyED patientsRespiratory arrestCardiac arrestClinical variablesAcute drugSevere outcomesTeaching hospitalBlood samples
2007
Identifying injection drug users at risk of nonfatal overdose.
Coffin P, Tracy M, Bucciarelli A, Ompad D, Vlahov D, Galea S. Identifying injection drug users at risk of nonfatal overdose. Academic Emergency Medicine 2007, 14: 616-23. PMID: 17554010, DOI: 10.1197/j.aem.2007.04.005.Peer-Reviewed Original ResearchConceptsDrug usersHabitual drug usersNonfatal overdoseAggressive prevention effortsAgonist maintenance treatmentSerious withdrawal symptomsInjection drug usersFurther longitudinal studiesIndividual-level risk factorsTake-home naloxoneOverdose prevention interventionsFuture overdosesMaintenance treatmentWithdrawal symptomsRisk factorsDrug overdoseRecent overdoseEmergency physiciansOverdose riskPrevention interventionsHigh riskOverdoseMedical careYounger ageU.S. adults
2005
The urban built environment and overdose mortality in New York City neighborhoods
Hembree C, Galea S, Ahern J, Tracy M, Piper T, Miller J, Vlahov D, Tardiff K. The urban built environment and overdose mortality in New York City neighborhoods. Health & Place 2005, 11: 147-156. PMID: 15629682, DOI: 10.1016/j.healthplace.2004.02.005.Peer-Reviewed Original ResearchConceptsAccidental drug overdoseNew York City HousingMultilevel case-control studyNew York City OfficeNew York City neighborhoodsAccidental overdose deathsFatal drug overdoseCharacteristics of neighborhoodsCity housingDrug overdose mortalityCity neighborhoodsVacancy SurveyMayor's OfficeDifferent neighborhoodsCity OfficeNeighborhood-level variablesNeighborhoodInternal environmentNeighborhood differencesExternal environmentOfficeEnvironmentHousingDisinvestmentSocial resources
2004
Overdose deaths attributed to methadone and heroin in New York City, 1990–1998
Bryant W, Galea S, Tracy M, Piper T, Tardiff K, Vlahov D. Overdose deaths attributed to methadone and heroin in New York City, 1990–1998. Addiction 2004, 99: 846-854. PMID: 15200580, DOI: 10.1111/j.1360-0443.2004.00693.x.Peer-Reviewed Original ResearchConceptsAccidental overdose deathsOverdose deathsOverdose mortalityAccidental drug overdose deathsPrescription of methadoneTotal overdose deathsRole of methadoneDrug overdose deathsChief Medical ExaminerNew York CityMethadone treatmentMethadoneEffective interventionsHeroinDeathYork CityMedical examinersRecent reportsMortalityPeriod of studySame intervalOpiatesPeriodProportion
1999
Pre-AIDS Mortality and Morbidity among Injection Drug Users in Amsterdam and Baltimore: An Ecological Comparison
van Ameijden E, Krol A, Vlahov D, Flynn C, van Haastrecht H, Coutinho R. Pre-AIDS Mortality and Morbidity among Injection Drug Users in Amsterdam and Baltimore: An Ecological Comparison. Substance Use & Misuse 1999, 34: 845-865. PMID: 10227114, DOI: 10.3109/10826089909037245.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphetaminesBaltimoreCause of DeathCocaineCohort StudiesComorbidityCost ControlCross-Cultural ComparisonDrug OverdoseEthanolFemaleHealth Services AccessibilityHeroinHIV SeropositivityHospitalizationHumansMaleMethadoneNetherlandsRisk FactorsSubstance Abuse, IntravenousSuicideSurvival RateUnited StatesConceptsDrug usersHigh-dose methadone maintenanceIncidence of hospitalizationSuicide mortalityEmergency room visitsInjection drug usersDifferent health care systemsHealth care systemHIV seropositivityRoom visitsHospital visitsMethadone maintenancePrimary careRecent injectingRisk factorsAIDS mortalityLower mortalityPolydrug useMortalityCare systemSocietal costsMorbidityVisitsHospitalizationBaltimore
1997
The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users
Lyles C, Margolick J, Astemborski J, Graham N, Anthony J, Hoover D, Vlahov D. The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users. AIDS 1997, 11: 1255-1262. PMID: 9256944, DOI: 10.1097/00002030-199710000-00009.Peer-Reviewed Original ResearchConceptsRate of CD4Lymphocyte countLymphocyte declineDrug use patternsDrug usersRate of declineDrug useMedian initial CD4Episodes of withdrawalSpecific drug typesDrug use variablesDrug use practicesPrevious CD4Initial CD4Mean changeOutcome measuresCD4Animal studiesDrug AdministrationEast BaltimoreDrug typeCells xLymphocytesInjection frequencyOutreach techniques
1994
Impact of HIV infection on non-AIDS mortality among Italian injecting drug users
Zaccarelli M, Gattari P, Rezza G, Conti S, Spizzichino L, Vlahov D, Ippolito G, Lelli V, Valenzi C. Impact of HIV infection on non-AIDS mortality among Italian injecting drug users. AIDS 1994, 8: 345-350. PMID: 8031512, DOI: 10.1097/00002030-199403000-00008.Peer-Reviewed Original ResearchConceptsHIV seropositivesHIV serostatusAIDS mortalityMortality rateAge-adjusted standardized mortality ratiosDrug usersHIV-negative IDUsHIV-seronegative IDUsHIV-seropositive IDUPerson-time techniquesStandardized mortality ratioCause-specific mortalityDrug treatment centersRate of deathHIV-seronegativesPossible HIVHIV infectionHIV testingProspective studyMortality ratioExcess mortalityGeneral populationOverdose mortalityAIDS causesHIV