Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users
Yu X, Wang Z, Vlahov D, Markham R, Farzadegan H, Margolick J. Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users. The Journal Of Infectious Diseases 1998, 178: 388-396. PMID: 9697718, DOI: 10.1086/515646.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineCells, CulturedDisease ProgressionFemaleGenetic VariationHIV Envelope Protein gp120HIV SeropositivityHIV-1HumansMaleMolecular Sequence DataPeptide FragmentsSequence Homology, Amino AcidSubstance Abuse, IntravenousT-LymphocytesTime FactorsConceptsInjection drug usersSI variantsDisease progressionHuman immunodeficiency virus type 1 variantsDrug usersHuman immunodeficiency virus type 1Immunodeficiency virus type 1HIV-1 transmissionT cell levelsSlow disease progressionT-cell declineDual-tropic virusesType 1 variantsSyncytium-inducing (SI) variantsVirus type 1T cell linesDual tropicNSI variantsSlow progressorsRapid progressionNSI phenotypeT cellsCell declineInitial infectionType 1