1999
New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users
Krol A, Flynn C, Vlahov D, Miedema F, Coutinho R, van Ameijden E. New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users. Drug And Alcohol Dependence 1999, 54: 145-154. PMID: 10217554, DOI: 10.1016/s0376-8716(98)00158-6.Peer-Reviewed Original ResearchCriteria for assessing cutaneous anergy in women with or at risk for HIV infection
Klein R, Flanigan T, Schuman P, Smith D, Vlahov D, Group* F. Criteria for assessing cutaneous anergy in women with or at risk for HIV infection. Journal Of Allergy And Clinical Immunology 1999, 103: 93-98. PMID: 9893191, DOI: 10.1016/s0091-6749(99)70531-2.Peer-Reviewed Original ResearchConceptsHIV statusCutaneous anergyHIV infectionTetanus antigensTuberculin reactionLevel of immunodeficiencyHIV-seronegative womenPositive tuberculin reactionAcademic medical centerAnergy testingLow CD4Seronegative subjectsHIV-seronegativeMumps antigenSeropositive subjectsSeropositive womenHIV-seropositiveLymphocyte levelsRisk womenTuberculin antigenTetanus toxoidCutaneous testingMedical CenterClinical utilityAntigen combinations
1998
Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline
Markham R, Wang W, Weisstein A, Wang Z, Munoz A, Templeton A, Margolick J, Vlahov D, Quinn T, Farzadegan H, Yu X. Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 12568-12573. PMID: 9770526, PMCID: PMC22871, DOI: 10.1073/pnas.95.21.12568.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCD4-Positive T-LymphocytesDNA PrimersEvolution, MolecularGenes, envHIV InfectionsHIV-1HumansLymphocyte DepletionMolecular Sequence DataPhylogenyConceptsCD4 T-cell declineT-cell declineCell declineHIV-1 env sequencesFirst seropositive visitModerate disease progressionCD4 T cellsInjection drug usersLow viral loadHIV-1 evolutionLater time pointsViral loadDisease progressionT cellsDrug usersPredominant virusNonsynonymous mutationsEnv sequencesTime pointsNonprogressorsTypes of mutationsDominant variantVisitsOnly quantitative differencesViral evolutionInfection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users
Yu X, Wang Z, Vlahov D, Markham R, Farzadegan H, Margolick J. Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users. The Journal Of Infectious Diseases 1998, 178: 388-396. PMID: 9697718, DOI: 10.1086/515646.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineCells, CulturedDisease ProgressionFemaleGenetic VariationHIV Envelope Protein gp120HIV SeropositivityHIV-1HumansMaleMolecular Sequence DataPeptide FragmentsSequence Homology, Amino AcidSubstance Abuse, IntravenousT-LymphocytesTime FactorsConceptsInjection drug usersSI variantsDisease progressionHuman immunodeficiency virus type 1 variantsDrug usersHuman immunodeficiency virus type 1Immunodeficiency virus type 1HIV-1 transmissionT cell levelsSlow disease progressionT-cell declineDual-tropic virusesType 1 variantsSyncytium-inducing (SI) variantsVirus type 1T cell linesDual tropicNSI variantsSlow progressorsRapid progressionNSI phenotypeT cellsCell declineInitial infectionType 1
1996
Existence and Failure of T-Cell Homeostasis Prior to AIDS Onset in HIV-Infected Injection Drug Users
Galai N, Margolick J, Astemborski J, Vlahov D. Existence and Failure of T-Cell Homeostasis Prior to AIDS Onset in HIV-Infected Injection Drug Users. Clinical Immunology 1996, 79: 134-141. PMID: 8620619, DOI: 10.1006/clin.1996.0060.Peer-Reviewed Original ResearchConceptsInjection drug usersTotal T cellsT cell homeostasisT cellsHIV infectionAIDS onsetAIDS diagnosisHomosexual menDrug usersCurrent injection drug useSeropositive injection drug usersInjection drug useT cell levelsImportant prognostic valueALIVE studyClinic visitsPrognostic valueRisk groupsT lymphocytesAIDS casesLate failureDrug useHIVAIDSMonthsTemporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992
Galai N, Lepri A, Vlahov D, Pezzotti P, Sinicco A, Rezza G, Study H. Temporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992. American Journal Of Epidemiology 1996, 143: 278-282. PMID: 8561162, DOI: 10.1093/oxfordjournals.aje.a008739.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCD4 Lymphocyte CountCD4-Positive T-LymphocytesCohort StudiesFemaleHIV AntibodiesHIV InfectionsHIV SeropositivityHIV-1HumansItalyLinear ModelsMaleMiddle AgedConceptsCD4 cell measurementsInitial CD4 cell countHuman immunodeficiency virus (HIV) seroconversionCD4 cell countCell countCD4 cell count increaseItalian Seroconversion StudyLow CD4 countMonths of seroconversionYear of seroconversionCD4 cell levelsCell count increaseMedian lag timeCD4 countCD4 levelsHIV seroconversionPositive serologyNegative serologyHIV seroconvertersClinical centersRisk groupsSeroconversion StudySeroconversionMultivariate modelLag time
1995
Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes.
Holmberg S, Conley L, Luby S, Cohn S, Wong L, Vlahov D. Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 9: 291. PMID: 7788428, DOI: 10.1097/00042560-199507000-00011.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCD4 T lymphocytesObservational cohort studyT lymphocytesCell countHIV seroconversionCohort studyHIV infectionImmunodeficiency virusOngoing observational cohort studyEarlier calendar yearsMore rapid declineLow CD4Mean CD4Recent infectionHIV-1CD4Drug usersBisexual menInfectionSeroconversionCalendar yearLymphocytesRapid lossFirst yearClinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users
Dorrucci M, Rezza G, Vlahov D, Pezzotti P, Sinicco A, Nicolosi A, Lazzarin A, Galai N, Gafà S, Pristerà R. Clinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users. AIDS 1995, 9: 597-604. PMID: 7662199, DOI: 10.1097/00002030-199506000-00011.Peer-Reviewed Original ResearchConceptsAcute retroviral syndromeHIV infectionHIV seroconvertersRelative hazardDrug usersFirst positive HIV testYear of seroconversionPositive HIV testRate of CD4Kaplan-Meier estimatesCumulative AIDS incidenceAsymptomatic seroconvertersHIV seroconversionClinical characteristicsHIV testClinical progressionPrognostic valueProspective studyClinical centersSeroconvertersCell declineSeroconversionCell countSyndromeNatural historyChanges in Markers of Disease Progression in HIV-1 Seroconverters
Galai N, Vlahov D, Margolick J, Chen K, Graham N, Munoz A. Changes in Markers of Disease Progression in HIV-1 Seroconverters. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 8: 66-82. PMID: 8548349, DOI: 10.1097/00042560-199501000-00011.Peer-Reviewed Original ResearchConceptsHomosexual menDrug usersDisease progressionRisk groupsHuman immunodeficiency virus (HIV) disease progressionHIV-1 seroconversionHIV-1 seroconvertersT lymphocyte subsetsImmune deficiency syndromeWhite homosexual menCD8 percentagesTotal lymphocytesHIV infectionSimilar CD4HIV seroconvertersDeficiency syndromeInitial courseSeroconversionCD4Long incubation periodSeroconvertersMenCohortInfectionSimilar rates
1994
Comparison of clinical manifestations of HIV infection between male and female injecting drug users
Vlahov D, Muñoz A, Solomon L, Astemborski J, Lindsay A, Anderson J, Galai N, Nelson K. Comparison of clinical manifestations of HIV infection between male and female injecting drug users. AIDS 1994, 8: 819-824. PMID: 7916193, DOI: 10.1097/00002030-199406000-00015.Peer-Reviewed Original ResearchConceptsCD4 cell countHIV infectionCell countDrug usersMedian CD4 cell countPosterior cervical lymph nodesAIDS-free HIVHIV-seropositive menCervical lymph nodesHIV-seronegative controlsDiagnosis of AIDSShortness of breathPhysical examination findingsHIV-seropositive participantsSymptoms of diarrheaHIV serologyGenital herpesLymphocyte countLymph nodesMedian ageSimilar CD4Examination findingsClinical manifestationsClinical symptomsConstitutional signsDirect Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users
Margolick J, Muñoz A, Vlahov D, Astemborski J, Solomon L, He X, Nelson K, Saah A. Direct Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users. JAMA Internal Medicine 1994, 154: 869-875. PMID: 7908795, DOI: 10.1001/archinte.1994.00420080065006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBisexualityCD4-Positive T-LymphocytesHIV SeropositivityHomosexualityHumansLeukocyte CountMaleSubstance Abuse, IntravenousConceptsHuman immunodeficiency virus-positive homosexual menLymphocyte countHomosexual menImmunodeficiency syndromeDrug usersRate of declineStudy entryClinical outcomesHuman immunodeficiency virus (HIV) infectionDevelopment of thrushMore frequent developmentImmunodeficiency virus infectionT cell subsetsInjecting Drug UsersProgression of diseaseRisk group membershipLower absolute numbersLymphocyte numbersClinical progressionClinical symptomsInitial levelDisease progressionVirus infectionStudy groupCD4Maturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users
Alcabes P, Muñoz A, Vlahov D, Friedland G. Maturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users. Annals Of Epidemiology 1994, 4: 17-26. PMID: 7911376, DOI: 10.1016/1047-2797(94)90038-8.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBaltimoreCD4-Positive T-LymphocytesCohort StudiesConfidence IntervalsHIV InfectionsHIV SeroprevalenceHomosexualityHumansIncidenceLeukocyte CountLife TablesMaleModels, StatisticalNew York CityPlatelet CountRegression AnalysisSubstance Abuse, IntravenousSurvival RateTime FactorsConceptsHIV infectionDrug usersImmunodeficiency syndromeMedian timeCombined cohortHomosexual menHuman immunodeficiency virus (HIV) infectionHuman immunodeficiency virus (HIV) epidemicPercent of CD4Immunodeficiency virus infectionIncident HIV infectionProduct-limit methodMarkers of maturityHIV incubation distributionsPlatelet countVirus infectionLarge cohortSeroconversionCohortInfectionConfidence intervalsIncubation distributionAIDSVirus epidemicPopulation groups
1993
Comparison of Clinical Symptoms of Human Immunodeficiency Virus Disease Between Intravenous Drug Users and Homosexual Men
Palenicek J, Nelson K, Vlahov D, Galai N, Cohn S, Saah A. Comparison of Clinical Symptoms of Human Immunodeficiency Virus Disease Between Intravenous Drug Users and Homosexual Men. JAMA Internal Medicine 1993, 153: 1806-1812. PMID: 8101438, DOI: 10.1001/archinte.1993.00410150094009.Peer-Reviewed Original ResearchConceptsIntravenous drug usersCD4 cell levelsClinical symptomsDrug usersHomosexual menOral candidiasisHIV infectionPhysical examinationRisk groupsMale intravenous drug usersHuman immunodeficiency virus (HIV) diseaseRisk behavior interviewsCD4 cell countTotal lymphocyte countIntravenous drug useShortness of breathMost clinical symptomsHIV-1 infectionHuman immunodeficiency virusFrequency of symptomsIntermediate outcome measuresCell levelAbnormal hematocritHIV immunosuppressionNight sweats
1992
Effect of Chronic Substance Abuse on the Neuropsychological Performance of Intravenous Drug Users with a High Prevalence of HIV-1 Seropositivity
Concha M, Graham N, Muñoz A, Vlahov D, Royal W, Updike M, Nance-Sproson T, Seines O, McArthur J. Effect of Chronic Substance Abuse on the Neuropsychological Performance of Intravenous Drug Users with a High Prevalence of HIV-1 Seropositivity. American Journal Of Epidemiology 1992, 136: 1338-1348. PMID: 1362630, DOI: 10.1093/oxfordjournals.aje.a116446.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBaltimoreBlack or African AmericanCD4-Positive T-LymphocytesChronic DiseaseCognition DisordersConfounding Factors, EpidemiologicEducational StatusEmploymentEvaluation Studies as TopicFemaleHIV SeropositivityHIV SeroprevalenceHIV-1HumansLeukocyte CountLinear ModelsMaleMass ScreeningNeuropsychological TestsPopulation SurveillancePredictive Value of TestsPrisonsPsychomotor PerformanceSubstance Abuse, IntravenousConceptsNeuropsychological test performanceHIV-1 seropositivityIntravenous drug usersTest performanceNeuropsychological performancePractice effectsHuman immunodeficiency virus type 1 (HIV-1) infectionDrug usersVirus type 1 infectionSubstance abuseSignificant practice effectsHIV-1 serostatusType 1 infectionIntravenous Experience (ALIVE) studyFrequency of drugChronic substance abuseNeuropsychological functioningCognitive performanceImmunodeficiency syndromeAsymptomatic stageHigh prevalenceOutcome measuresDrug useIntoxicated individualsMultivariate analysisImmune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users.
Chaisson R, Taylor E, Margolick J, Muñoz A, Solomon L, Cohn S, Nelson K, Vlahov D. Immune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 456. PMID: 1348535, DOI: 10.1097/00126334-199205000-00004.Peer-Reviewed Original ResearchConceptsCD4 cell countSerum immune markersDrug use patternsCell countCD4 countHIV statusImmune markersImmune activationDrug usersHuman immunodeficiency virus (HIV) infectionHIV-seropositive individualsImmunodeficiency virus infectionSerum IgA levelsIntravenous drug usersAssociation of raceIgA levelsNeopterin levelsSerum markersVirus infectionLarge cohortBacterial infectionsHIVHepatitisInfectionMarkersChanges in T-Lymphocyte Subsets in Intravenous Drug Users With HIV-1 Infection
Margolick J, Muñoz A, Vlahov D, Solomon L, Astemborski J, Cohn S, Nelson K. Changes in T-Lymphocyte Subsets in Intravenous Drug Users With HIV-1 Infection. JAMA 1992, 267: 1631-1636. PMID: 1347321, DOI: 10.1001/jama.1992.03480120069035.Peer-Reviewed Original ResearchConceptsSeropositive intravenous drug usersIntravenous drug usersHIV-1 infectionHIV-1-seropositive intravenous drug usersDrug usersCell countSeronegative intravenous drug usersHuman immunodeficiency virus type 1Complete blood cell countImmunodeficiency virus type 1Absolute numberCD4 cell countCD4 lymphocyte countPercentage of CD4T lymphocyte subsetsCD8 T cellsT cell subsetsCommunity-based clinicsBlood cell countTime of seroconversionVirus type 1Multivariate regression analysisUse of drugsCD4 lymphocytesCD8 lymphocytes
1991
Antibody Responses to Haemophilus influenzae Type b Vaccines in Men with Human Immunodeficiency Virus Infection
Steinhoff M, Auerbach B, Nelson K, Vlahov D, Becker R, Graham N, Schwartz D, Lucas A, Chaisson R. Antibody Responses to Haemophilus influenzae Type b Vaccines in Men with Human Immunodeficiency Virus Infection. New England Journal Of Medicine 1991, 325: 1837-1842. PMID: 1683682, DOI: 10.1056/nejm199112263252603.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionInfluenzae type b vaccineAsymptomatic HIV infectionImmunodeficiency virus infectionSymptomatic HIV infectionType b vaccineHIV infectionAntibody responsePRP vaccineB vaccineVirus infectionH. influenzae type b vaccineHaemophilus influenzae type b vaccineType b polysaccharide vaccineGeometric mean antibody titersHIV-seropositive menPRP antibody titersPutative protective levelGreater antibody responseH. influenzae type b.Mean antibody titersSeronegative subjectsCD4 lymphocytesPolysaccharide vaccineSeronegative men
1990
Blood and Plasma Donations Among a Cohort of Intravenous Drug Users
Nelson K, Vlahov D, Margolick J, Bernal M, Taylor E. Blood and Plasma Donations Among a Cohort of Intravenous Drug Users. JAMA 1990, 263: 2194-2197. PMID: 1969502, DOI: 10.1001/jama.1990.03440160056037.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHIV-1 seroprevalenceIntravenous drug useDrug usersHuman immunodeficiency virus serologic statusDrug useHIV test resultsCD4 lymphocytesEntire cohortPeripheral bloodSerologic statusDonor poolIntravenous drugsHIV-1Blood donationMost subjectsPlasma donationBloodCohortDonation historySeroprevalenceDonationLymphocytesHistoryPlasma