2001
Isoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis
Sadaphal P, Astemborski J, Graham N, Sheely L, Bonds M, Madison A, Vlahov D, Thomas D, Sterling T. Isoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis. Clinical Infectious Diseases 2001, 33: 1687-1691. PMID: 11641824, PMCID: PMC2650436, DOI: 10.1086/323896.Peer-Reviewed Original ResearchConceptsHepatitis C virusInjection drug usersTuberculosis infectionValue elevationDrug usersCurrent injection drug useLatent Mycobacterium tuberculosis infectionHepatitis C virus infectionHepatitis B surface antigenLow HCV prevalenceC virus infectionIsoniazid preventive therapyInjection drug useM. tuberculosis infectionMycobacterium tuberculosis infectionHIV-1 infectionHuman immunodeficiency virusB surface antigenConcurrent alcohol useDrug discontinuationHCV prevalencePreventive therapyImmunodeficiency virusProspective studyTransaminase values
1999
Comparison between a Whole Blood Interferon-γ Release Assay and Tuberculin Skin Testing for the Detection of Tuberculosis Infection among Patients at Risk for Tuberculosis Exposure
Kimura M, Converse P, Astemborski J, Rothel J, Vlahov D, Comstock G, Graham N, Chaisson R, Bishai W. Comparison between a Whole Blood Interferon-γ Release Assay and Tuberculin Skin Testing for the Detection of Tuberculosis Infection among Patients at Risk for Tuberculosis Exposure. The Journal Of Infectious Diseases 1999, 179: 1297-1300. PMID: 10191241, DOI: 10.1086/314707.Peer-Reviewed Original ResearchConceptsTuberculin skin testIFN-gamma releaseTuberculosis infectionWhole-Blood Interferon-γ Release AssayStandard tuberculin skin testInterferon-γ release assaysPercent agreementCulture-confirmed tuberculosisHIV-seropositive subjectsTuberculin skin testingHuman immunodeficiency virusInterferon-gamma releaseIntravenous drug usersSingle blood drawSeronegative patientsTuberculosis exposureSkin testingUninfected personsImmunodeficiency virusSkin testBlood drawUrban BaltimoreDrug usersRelease assaysFurther evaluation
1998
Mycobacterium tuberculosis infection and disease are not associated with protection against subsequent disseminated M. avium complex disease
Sterling T, Moore R, Graham N, Astemborski J, Vlahov D, Chaisson R. Mycobacterium tuberculosis infection and disease are not associated with protection against subsequent disseminated M. avium complex disease. AIDS 1998, 12: 1451-1457. PMID: 9727565, DOI: 10.1097/00002030-199812000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsAntibiotic ProphylaxisAntitubercular AgentsCD4 Lymphocyte CountCohort StudiesFemaleHumansMaleMiddle AgedMycobacterium avium ComplexMycobacterium avium-intracellulare InfectionMycobacterium tuberculosisProspective StudiesRisk FactorsSubstance Abuse, IntravenousTuberculosisConceptsM. tuberculosis infectionM. avium complex diseaseMycobacterium tuberculosis infectionDisseminated MACTuberculosis infectionExtrapulmonary tuberculosisDrug useLow CD4 cell levelsProspective observational cohort studyAdult HIV clinicIntravenous Experience cohortPrior opportunistic infectionsCD4 cell levelsObservational cohort studyLogistic regression analysisALIVE cohortAntibiotic prophylaxisMAC prophylaxisAntiretroviral therapyCD4 lymphocytesHIV clinicMAC diseaseActive tuberculosisCohort studyOpportunistic infectionsTuberculosis Risk in Funeral Home Employees
Gershon R, Vlahov D, Escamilla-Cejudo J, Badawi M, McDiarmid M, Karkashian C, Grimes M, Comstock G. Tuberculosis Risk in Funeral Home Employees. Journal Of Occupational And Environmental Medicine 1998, 40: 497-503. PMID: 9604188, DOI: 10.1097/00043764-199805000-00014.Peer-Reviewed Original ResearchConceptsTuberculin skin testTuberculin skin testingSkin testingSkin testAnnual tuberculin skin testingReactive tuberculin skin testHome employeesPast historyRisk assessment questionnaireTuberculin reactivityTuberculosis infectionTuberculosis riskTuberculosis casesTuberculosis preventionInfected individualsStudy participantsClose contactConvenience sampleRespiratory protectionJob categoriesAgeRiskRisk assessment studiesNumber of yearsHistory
1996
The Effect of Latent Mycobacterium tuberculosis Infection on Human Immunodeficiency Virus (HIV) Disease Progression and HIV RNA Load among Injecting Drug Users
Manoff S, Farzadegan H, Muñoz A, Astemborski J, Vlahov D, Rizzo R, Solomon L, Graham N. The Effect of Latent Mycobacterium tuberculosis Infection on Human Immunodeficiency Virus (HIV) Disease Progression and HIV RNA Load among Injecting Drug Users. The Journal Of Infectious Diseases 1996, 174: 299-308. PMID: 8699059, DOI: 10.1093/infdis/174.2.299.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) disease progressionLatent Mycobacterium tuberculosis infectionMycobacterium tuberculosis infectionTuberculosis infectionSkin testingDisease progressionDrug usersLatent M. tuberculosis infectionTuberculin positive casesTuberculin-negative controlsTuberculin-negative personsCD4 cell countCohort of HIVHIV RNA loadCD4 cell declineM. tuberculosis infectionTuberculin skin testingInjecting Drug UsersBaseline immune functionHIV concentrationHIV RNAActive tuberculosisHIV burdenHIV progressionRNA load