2001
Sexual and drug risk-related behaviours after initiating highly active antiretroviral therapy among injection drug users
Vlahov D, Safaien M, Lai S, Strathdee S, Johnson L, Sterling T, Celentano D. Sexual and drug risk-related behaviours after initiating highly active antiretroviral therapy among injection drug users. AIDS 2001, 15: 2311-2316. PMID: 11698705, DOI: 10.1097/00002030-200111230-00013.Peer-Reviewed Original ResearchConceptsInjection drug usersHIV-seropositive injection drug usersActive antiretroviral therapyUntreated groupHigh-risk behaviorsAntiretroviral therapyConsecutive visitsDrug usersRisk behaviorsInitiation of HAARTCD4 cell countOngoing prospective studySemi-annual interviewsLinear growth curve analysesHAART useMedian ageMedication useProspective studyNeedle sharingHAARTCell countUnprotected sexRisk-related behaviorsCurve analysisStudy periodMortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women: Longitudinal Analysis From the HIV Epidemiology Research Study
Ickovics J, Hamburger M, Vlahov D, Schoenbaum E, Schuman P, Boland R, Moore J, Group F. Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women: Longitudinal Analysis From the HIV Epidemiology Research Study. JAMA 2001, 285: 1466-1474. PMID: 11255423, DOI: 10.1001/jama.285.11.1466.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusChronic depressive symptomsCD4 cell countHIV-seropositive womenTreatment of depressionDepressive symptomsCell countDisease progressionBaseline CD4 cell countCD4 cell count declineHIV Epidemiologic Research StudyCell count declineCD4 lymphocyte countBaseline viral loadEpidemiologic Studies Depression ScaleHIV disease progressionHIV Epidemiology Research StudyLongitudinal cohort studyEpidemiologic research studiesImpact of depressionAcademic medical centerSelf-reported CenterCohort studyLymphocyte countCount decline
1999
Longitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load
Lyles C, Dorrucci M, Vlahov D, Pezzotti P, Angarano G, Sinicco A, Alberici F, Alcorn T, Vella S, Rezza G. Longitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load. The Journal Of Infectious Diseases 1999, 180: 1018-1024. PMID: 10479126, DOI: 10.1086/314980.Peer-Reviewed Original ResearchConceptsHIV-1 loadVirus loadHuman immunodeficiency virus type 1 (HIV-1) loadHuman immunodeficiency virus type 1 (HIV-1) seroconvertersCD4 cells/microL.Low CD4 cell countsItalian Seroconversion StudyCD4 cell countCells/microL.Injection drug useCourse of diseaseReverse transcriptase-polymerase chain reactionHigh virus loadTranscriptase-polymerase chain reactionClinical AIDSMale sexProspective studyDisease progressionSeroconversion StudyCell countDrug useSustained increaseSeroconversionAIDSFrozen serumSelf-Reported Bacterial Infections Among Women with or at Risk for Human Immunodeficiency Virus Infection
Flanigan T, Hogan J, Smith D, Schoenbaum E, Vlahov D, Schuman P, Mayer K. Self-Reported Bacterial Infections Among Women with or at Risk for Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 1999, 29: 608-612. PMID: 10530455, DOI: 10.1086/598641.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionCD4 cell countImmunodeficiency virus infectionBacterial infectionsRecent pneumoniaVirus infectionCell countHIV-negative womenHIV-seropositive womenUrinary tract infectionInjection drug useLogistic regression analysisSelf-reported pneumoniaCross-sectional analysisSeronegative womenTract infectionsHIV infectionDrug useLifetime historyInfectionPneumoniaMajor causeWomenRegression analysisCell categories
1998
Sex differences in HIV-1 viral load and progression to AIDS
Farzadegan H, Hoover D, Astemborski J, Lyles C, Margolick J, Markham R, Quinn T, Vlahov D. Sex differences in HIV-1 viral load and progression to AIDS. The Lancet 1998, 352: 1510-1514. PMID: 9820299, DOI: 10.1016/s0140-6736(98)02372-1.Peer-Reviewed Original ResearchConceptsInjection drug usersCD4 cell countProportional hazards modelBranched-chain DNAViral loadQuantitative microcultureReverse transcriptase-PCRPlasma HIV-1 RNA measurementsCell countHIV-1 RNA measurementsUnivariate proportional hazard modelHIV-1 viral loadSame viral loadViral load associationsVisit 3 yearsHIV-1 loadViral load measurementsAntiretroviral therapyAntiretroviral treatmentBaseline visitCommunity clinicsObservational studyHIV-1Current recommendationsHigh riskViolence Among Women with or at Risk for HIV Infection
Vlahov D, Wientge D, Moore J, Flynn C, Schuman P, Schoenbaum E, Zierler S, Rompalo A, Sobel J, Klein R, Carpenter C, Mayer K, Smith D, Warren D, Duerr A, Peterson B, Holmberg S, Miotti P, McKinley S. Violence Among Women with or at Risk for HIV Infection. AIDS And Behavior 1998, 2: 53-60. DOI: 10.1023/a:1022359307814.Peer-Reviewed Original ResearchLow CD4 cell countsCD4 cell countHIV-seronegative womenHIV-seropositiveHIV infectionHigh riskSex partnersCell countInjection drug useEffects of HIVLongitudinal cohort studyMultiple sex partnersHigh-risk sexCross-sectional surveySteady sex partnerPhysical abuseUninfected womenCohort studyHIV preventionAppropriate counseling servicesTreatment servicesDrug useHIVUse of marijuanaSexual abuse
1997
Markers of response to zidovudine monotherapy among treated HIV seroconverters. Italian Seroconversion Study.
Rezza G, Galai N, Pezzotti P, Vlahov D, Graham N, Viale P, Angarano G. Markers of response to zidovudine monotherapy among treated HIV seroconverters. Italian Seroconversion Study. Antiviral Therapy 1997, 2: 167-74. PMID: 11322271.Peer-Reviewed Original ResearchConceptsCD4 cell countInitiation of treatmentZidovudine monotherapyP24 antigenaemiaCell countConstitutional symptomsHIV seroconvertersRisk groupsCopies/Human immunodeficiency virus seroconvertersPlasma RNA viral loadHIV RNA copiesCD4 cell declineRNA viral loadStart of therapyMarker of responseAntigen-positive individualsAdditional predictive informationIndicator of responseStandard survival methodsTerms of progressionAntiretroviral therapyViral loadAntigen levelsDisease progression
1996
The Effect of Latent Mycobacterium tuberculosis Infection on Human Immunodeficiency Virus (HIV) Disease Progression and HIV RNA Load among Injecting Drug Users
Manoff S, Farzadegan H, Muñoz A, Astemborski J, Vlahov D, Rizzo R, Solomon L, Graham N. The Effect of Latent Mycobacterium tuberculosis Infection on Human Immunodeficiency Virus (HIV) Disease Progression and HIV RNA Load among Injecting Drug Users. The Journal Of Infectious Diseases 1996, 174: 299-308. PMID: 8699059, DOI: 10.1093/infdis/174.2.299.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) disease progressionLatent Mycobacterium tuberculosis infectionMycobacterium tuberculosis infectionTuberculosis infectionSkin testingDisease progressionDrug usersLatent M. tuberculosis infectionTuberculin positive casesTuberculin-negative controlsTuberculin-negative personsCD4 cell countCohort of HIVHIV RNA loadCD4 cell declineM. tuberculosis infectionTuberculin skin testingInjecting Drug UsersBaseline immune functionHIV concentrationHIV RNAActive tuberculosisHIV burdenHIV progressionRNA loadTemporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992
Galai N, Lepri A, Vlahov D, Pezzotti P, Sinicco A, Rezza G, Study H. Temporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992. American Journal Of Epidemiology 1996, 143: 278-282. PMID: 8561162, DOI: 10.1093/oxfordjournals.aje.a008739.Peer-Reviewed Original ResearchConceptsCD4 cell measurementsInitial CD4 cell countHuman immunodeficiency virus (HIV) seroconversionCD4 cell countCell countCD4 cell count increaseItalian Seroconversion StudyLow CD4 countMonths of seroconversionYear of seroconversionCD4 cell levelsCell count increaseMedian lag timeCD4 countCD4 levelsHIV seroconversionPositive serologyNegative serologyHIV seroconvertersClinical centersRisk groupsSeroconversion StudySeroconversionMultivariate modelLag time
1995
Instability of Delayed-type Hypersensitivity Skin Test Anergy in Human Immunodeficiency Virus Infection
Caiaffa W, Graham N, Galai N, Rizzo R, Nelson K, Vlahov D. Instability of Delayed-type Hypersensitivity Skin Test Anergy in Human Immunodeficiency Virus Infection. JAMA Internal Medicine 1995, 155: 2111-2117. PMID: 7575072, DOI: 10.1001/archinte.1995.00430190107015.Peer-Reviewed Original ResearchConceptsHIV-seropositive subjectsHIV-seronegative subjectsCD4 cell countSkin test resultsDrug usersCell countDTH anergyDTH positivityDelayed-type hypersensitivity (DTH) skin testDelayed-type hypersensitivity anergyHuman immunodeficiency virus (HIV) infectionDTH skin testingSkin test anergyImmunodeficiency virus infectionCommunity-based cohortHuman immunodeficiency virusHypersensitivity skin testsCandida albicans antigenAnergy testingSerial skinCD4 cellsHIV statusSingle testSkin testingImmunodeficiency virusFactors Associated with Initiation of Zidovudine in a Cohort of Injection Drug Users
Solomon L, Vlahov D, Astemborski J, Galai N, Graham N, Nelson K. Factors Associated with Initiation of Zidovudine in a Cohort of Injection Drug Users. Journal Of Drug Issues 1995, 25: 225-233. DOI: 10.1177/002204269502500115.Peer-Reviewed Original Research
1994
Comparison of clinical manifestations of HIV infection between male and female injecting drug users
Vlahov D, Muñoz A, Solomon L, Astemborski J, Lindsay A, Anderson J, Galai N, Nelson K. Comparison of clinical manifestations of HIV infection between male and female injecting drug users. AIDS 1994, 8: 819-824. PMID: 7916193, DOI: 10.1097/00002030-199406000-00015.Peer-Reviewed Original ResearchConceptsCD4 cell countHIV infectionCell countDrug usersMedian CD4 cell countPosterior cervical lymph nodesAIDS-free HIVHIV-seropositive menCervical lymph nodesHIV-seronegative controlsDiagnosis of AIDSShortness of breathPhysical examination findingsHIV-seropositive participantsSymptoms of diarrheaHIV serologyGenital herpesLymphocyte countLymph nodesMedian ageSimilar CD4Examination findingsClinical manifestationsClinical symptomsConstitutional signsProfile of HIV seropositive inmates diagnosed in Maryland's state correctional system.
Kendig N, Stough T, Austin P, Kummer L, Swetz A, Vlahov D. Profile of HIV seropositive inmates diagnosed in Maryland's state correctional system. Public Health Reports 1994, 109: 756-60. PMID: 7800784, PMCID: PMC1403577.Peer-Reviewed Original ResearchConceptsHIV infectionInfected inmatesHigher CD4 cell countsHuman immunodeficiency virus (HIV) infectionHIV-seropositive inmatesCD4 cell countImmunodeficiency virus infectionAnti-retroviral therapyVoluntary HIV testingPrimary care providersClinical case managementPublic health interventionsState correctional systemCorrectional settingsImmediate medical treatmentClinical profileHIV testingInitial diagnosisVirus infectionCare providersMedical treatmentCell countHealth interventionsCase managementInfection
1993
Comparison of Clinical Symptoms of Human Immunodeficiency Virus Disease Between Intravenous Drug Users and Homosexual Men
Palenicek J, Nelson K, Vlahov D, Galai N, Cohn S, Saah A. Comparison of Clinical Symptoms of Human Immunodeficiency Virus Disease Between Intravenous Drug Users and Homosexual Men. JAMA Internal Medicine 1993, 153: 1806-1812. PMID: 8101438, DOI: 10.1001/archinte.1993.00410150094009.Peer-Reviewed Original ResearchConceptsIntravenous drug usersCD4 cell levelsClinical symptomsDrug usersHomosexual menOral candidiasisHIV infectionPhysical examinationRisk groupsMale intravenous drug usersHuman immunodeficiency virus (HIV) diseaseRisk behavior interviewsCD4 cell countTotal lymphocyte countIntravenous drug useShortness of breathMost clinical symptomsHIV-1 infectionHuman immunodeficiency virusFrequency of symptomsIntermediate outcome measuresCell levelAbnormal hematocritHIV immunosuppressionNight sweats
1992
Immune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users.
Chaisson R, Taylor E, Margolick J, Muñoz A, Solomon L, Cohn S, Nelson K, Vlahov D. Immune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 456. PMID: 1348535, DOI: 10.1097/00126334-199205000-00004.Peer-Reviewed Original ResearchConceptsCD4 cell countSerum immune markersDrug use patternsCell countCD4 countHIV statusImmune markersImmune activationDrug usersHuman immunodeficiency virus (HIV) infectionHIV-seropositive individualsImmunodeficiency virus infectionSerum IgA levelsIntravenous drug usersAssociation of raceIgA levelsNeopterin levelsSerum markersVirus infectionLarge cohortBacterial infectionsHIVHepatitisInfectionMarkersChanges in T-Lymphocyte Subsets in Intravenous Drug Users With HIV-1 Infection
Margolick J, Muñoz A, Vlahov D, Solomon L, Astemborski J, Cohn S, Nelson K. Changes in T-Lymphocyte Subsets in Intravenous Drug Users With HIV-1 Infection. JAMA 1992, 267: 1631-1636. PMID: 1347321, DOI: 10.1001/jama.1992.03480120069035.Peer-Reviewed Original ResearchConceptsSeropositive intravenous drug usersIntravenous drug usersHIV-1 infectionHIV-1-seropositive intravenous drug usersDrug usersCell countSeronegative intravenous drug usersHuman immunodeficiency virus type 1Complete blood cell countImmunodeficiency virus type 1Absolute numberCD4 cell countCD4 lymphocyte countPercentage of CD4T lymphocyte subsetsCD8 T cellsT cell subsetsCommunity-based clinicsBlood cell countTime of seroconversionVirus type 1Multivariate regression analysisUse of drugsCD4 lymphocytesCD8 lymphocytesPrognostic indicators for development of AIDS among intravenous drug users.
Muñoz A, Vlahov D, Solomon L, Margolick J, Bareta J, Cohn S, Astemborski J, Nelson K. Prognostic indicators for development of AIDS among intravenous drug users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 694-700. PMID: 1613668.Peer-Reviewed Original ResearchConceptsCD4 cell countIntravenous drug usersClinical symptomsDrug usersCell countHigher CD4 cell countsHIV-1-related symptomsSeropositive intravenous drug usersPneumocystis carinii prophylaxisIntravenous drug useDevelopment of AIDSDose-response relationshipYear of enrollmentSerum neopterinLaboratory markersSerum betaPrognostic indicatorClinical evaluationAntiviral agentsRelative hazardDrug useSurvival analysisMultivariate analysisSignificant associationAIDS
1991
HIV-1 infection and nervous system abnormalities among a cohort of intravenous drug users.
Royal W, Updike M, Seines O, Proctor T, Nance-Sproson L, Solomon L, Vlahov D, Cornblath D, McArthur J. HIV-1 infection and nervous system abnormalities among a cohort of intravenous drug users. Neurology 1991, 41: 1905-10. PMID: 1745346, DOI: 10.1212/wnl.41.12.1905.Peer-Reviewed Original ResearchConceptsHIV-1 serostatusIntravenous drug usersNeurologic abnormalitiesDrug usersSeronegative intravenous drug usersCD4 cell countHIV-seropositive subjectsHIV-1 infectionNervous system abnormalitiesConstitutional symptomsElectrophysiologic evaluationSeropositive participantsSeropositive subjectsElectrophysiologic abnormalitiesHIV infectionStudy cohortNeurologic diseaseSystem abnormalitiesHomosexual menCell countSerologic groupsCohortAbnormalitiesClear associationNeuropsychological testsUtilization of health services in a cohort of intravenous drug users with known HIV-1 serostatus.
Solomon L, Frank R, Vlahov D, Astemborski J. Utilization of health services in a cohort of intravenous drug users with known HIV-1 serostatus. American Journal Of Public Health 1991, 81: 1285-90. PMID: 1928527, PMCID: PMC1405342, DOI: 10.2105/ajph.81.10.1285.Peer-Reviewed Original ResearchConceptsIntravenous drug usersCD4 cell countDrug usersHealth servicesHIV serostatusClinical symptomsHIV-seropositive intravenous drug usersHealth insuranceCell countAsymptomatic HIV-1 infectionSeropositive intravenous drug usersHuman immunodeficiency virus (HIV) infectionHIV-seropositive drug usersOngoing natural history studyLow CD4 countHIV-1 seropositiveImmunodeficiency virus infectionHIV-1 serostatusHealth care utilizationHIV-1 infectionHIV-positive serostatusNatural history studiesHealth care servicesCD4 countMore HIV