2004
Increase in Sexual Risk Behavior Associated with Immunologic Response to Highly Active Antiretroviral Therapy among HIV-Infected Injection Drug Users
Tun W, Gange S, Vlahov D, Strathdee S, Celentano D. Increase in Sexual Risk Behavior Associated with Immunologic Response to Highly Active Antiretroviral Therapy among HIV-Infected Injection Drug Users. Clinical Infectious Diseases 2004, 38: 1167-1174. PMID: 15095224, DOI: 10.1086/383033.Peer-Reviewed Original ResearchConceptsInjection drug usersActive antiretroviral therapyHAART initiationCell countAntiretroviral therapyDrug usersSexual intercourseRisk reduction counselingHuman immunodeficiency virusLarge cohort studyDrug injection behaviorInjection of drugsUnprotected sexual intercourseSemiannual visitsReduction counselingCohort studyHIV infectionHIV serostatusImmunodeficiency virusImmunologic responseNeedle sharingBlood samplesSurvival analysisRisk behaviorsCD4
2002
Risk factors and cumulative incidence of anaemia among HIV-infected injection drug users
Semba R, Shah N, Vlahov D. Risk factors and cumulative incidence of anaemia among HIV-infected injection drug users. International Journal Of STD & AIDS 2002, 13: 119-123. PMID: 11839167, DOI: 10.1258/0956462021924758.Peer-Reviewed Original ResearchConceptsInjection drug usersCumulative incidenceRisk factorsDrug usersMycobacterium avium complex infectionHigher body mass indexBody mass indexLongitudinal cohort studyZidovudine useCohort studyLymphocyte countOral thrushMass indexComplex infectionFemale genderHigh riskLower riskAnemiaMicrocytic anemiaIncidenceWeight lossCells/Marijuana useRiskCD4
1999
New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users
Krol A, Flynn C, Vlahov D, Miedema F, Coutinho R, van Ameijden E. New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users. Drug And Alcohol Dependence 1999, 54: 145-154. PMID: 10217554, DOI: 10.1016/s0376-8716(98)00158-6.Peer-Reviewed Original Research
1998
HIV/HTLV-II Coinfection and CD4+ Cell Count Controlling for Plasma HIV Viral Load in Injection Drug Users in Baltimore
Zhang H, Flynn C, Nelson K, Chen W, Kawalski R, Vlahov D. HIV/HTLV-II Coinfection and CD4+ Cell Count Controlling for Plasma HIV Viral Load in Injection Drug Users in Baltimore. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: 397-398. PMID: 9704951, DOI: 10.1097/00042560-199808010-00018.Peer-Reviewed Original ResearchGenetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Winkler C, Modi W, Smith M, Nelson G, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert J, O'Brien T, Jacobson L, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, Study A, Study H, Study M, Study M, Cohort S, O'Brien S. Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant. Science 1998, 279: 389-393. PMID: 9430590, DOI: 10.1126/science.279.5349.389.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultChemokine CXCL12ChemokinesChemokines, CXCCohort StudiesDisease ProgressionGenesGenetic VariationGenotypeHeterozygoteHIV InfectionsHIV-1HumansMaleMolecular Sequence DataOdds RatioPolymorphism, GeneticRacial GroupsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CXCR4Survival AnalysisT-LymphocytesConceptsSDF1-3'AGenetic restrictionRecessive protective effectOnset of AIDSAIDS Cohort StudyStromal-derived factorCohort studyImmunodeficiency syndromeAIDS pathogenesisHuman immunodeficiencyHIV-1Protective effectCommon polymorphismsReceptor variantsGene variantsPrincipal ligandAIDSHomozygous stateGenetic association analysisOnsetCD4CCR5PatientsGene transcriptsImmunodeficiency
1997
The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users
Lyles C, Margolick J, Astemborski J, Graham N, Anthony J, Hoover D, Vlahov D. The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users. AIDS 1997, 11: 1255-1262. PMID: 9256944, DOI: 10.1097/00002030-199710000-00009.Peer-Reviewed Original ResearchConceptsRate of CD4Lymphocyte countLymphocyte declineDrug use patternsDrug usersRate of declineDrug useMedian initial CD4Episodes of withdrawalSpecific drug typesDrug use variablesDrug use practicesPrevious CD4Initial CD4Mean changeOutcome measuresCD4Animal studiesDrug AdministrationEast BaltimoreDrug typeCells xLymphocytesInjection frequencyOutreach techniques
1995
Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes.
Holmberg S, Conley L, Luby S, Cohn S, Wong L, Vlahov D. Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 9: 291. PMID: 7788428, DOI: 10.1097/00042560-199507000-00011.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCD4 T lymphocytesObservational cohort studyT lymphocytesCell countHIV seroconversionCohort studyHIV infectionImmunodeficiency virusOngoing observational cohort studyEarlier calendar yearsMore rapid declineLow CD4Mean CD4Recent infectionHIV-1CD4Drug usersBisexual menInfectionSeroconversionCalendar yearLymphocytesRapid lossFirst yearChanges in Markers of Disease Progression in HIV-1 Seroconverters
Galai N, Vlahov D, Margolick J, Chen K, Graham N, Munoz A. Changes in Markers of Disease Progression in HIV-1 Seroconverters. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 8: 66-82. PMID: 8548349, DOI: 10.1097/00042560-199501000-00011.Peer-Reviewed Original ResearchConceptsHomosexual menDrug usersDisease progressionRisk groupsHuman immunodeficiency virus (HIV) disease progressionHIV-1 seroconversionHIV-1 seroconvertersT lymphocyte subsetsImmune deficiency syndromeWhite homosexual menCD8 percentagesTotal lymphocytesHIV infectionSimilar CD4HIV seroconvertersDeficiency syndromeInitial courseSeroconversionCD4Long incubation periodSeroconvertersMenCohortInfectionSimilar rates
1994
Direct Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users
Margolick J, Muñoz A, Vlahov D, Astemborski J, Solomon L, He X, Nelson K, Saah A. Direct Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users. JAMA Internal Medicine 1994, 154: 869-875. PMID: 7908795, DOI: 10.1001/archinte.1994.00420080065006.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-positive homosexual menLymphocyte countHomosexual menImmunodeficiency syndromeDrug usersRate of declineStudy entryClinical outcomesHuman immunodeficiency virus (HIV) infectionDevelopment of thrushMore frequent developmentImmunodeficiency virus infectionT cell subsetsInjecting Drug UsersProgression of diseaseRisk group membershipLower absolute numbersLymphocyte numbersClinical progressionClinical symptomsInitial levelDisease progressionVirus infectionStudy groupCD4