2024
BIDCell: Biologically-informed self-supervised learning for segmentation of subcellular spatial transcriptomics data
Fu X, Lin Y, Lin D, Mechtersheimer D, Wang C, Ameen F, Ghazanfar S, Patrick E, Kim J, Yang J. BIDCell: Biologically-informed self-supervised learning for segmentation of subcellular spatial transcriptomics data. Nature Communications 2024, 15: 509. PMID: 38218939, PMCID: PMC10787788, DOI: 10.1038/s41467-023-44560-w.Peer-Reviewed Original ResearchMeSH KeywordsBenchmarkingErythrocytes, AbnormalGene Expression ProfilingHistocompatibility TestingSupervised Machine LearningConceptsGene expressionSingle-cell transcriptomic dataSpatial expression analysisMap of gene expressionSpatial mapping of gene expressionTranscriptome dataBiological discoveryExpression analysisTranscriptomic platformsOversized cellsPublic repositoriesCell morphologyState-of-the-art methodsSelf-supervised learningDeep learning-based frameworkState-of-the-artTissue typesLearning-based frameworkHigh-resolution spatial mappingCellsExpressionSignificant analytical challengeSegmentation performanceLoss functionRecent advances
2023
Atlas-scale single-cell multi-sample multi-condition data integration using scMerge2
Lin Y, Cao Y, Willie E, Patrick E, Yang J. Atlas-scale single-cell multi-sample multi-condition data integration using scMerge2. Nature Communications 2023, 14: 4272. PMID: 37460600, PMCID: PMC10352351, DOI: 10.1038/s41467-023-39923-2.Peer-Reviewed Original ResearchAlgorithmsCOVID-19Exome SequencingGene Expression ProfilingHumansSequence Analysis, RNASingle-Cell Analysis
2020
CiteFuse enables multi-modal analysis of CITE-seq data
Kim H, Lin Y, Geddes T, Yang J, Yang P. CiteFuse enables multi-modal analysis of CITE-seq data. Bioinformatics 2020, 36: 4137-4143. PMID: 32353146, DOI: 10.1093/bioinformatics/btaa282.Peer-Reviewed Original ResearchMeSH KeywordsEpitopesGene Expression ProfilingRNASequence Analysis, RNASingle-Cell AnalysisSoftwareTranscriptomeConceptsCITE-seq dataLigand-receptor interaction analysisCell surface proteinsMulti-modal profilingProtein expression analysisLigand-receptor interactionsCell hashingDifferential RNATranscriptome dataDistinct speciesCellular indexingExpression analysisDoublet detectionIntegrative analysisMolecular biologyStreamlined packageTranscriptomeSingle cellsInteractive web-based visualizationSupplementary dataRNAR packageProfilingEpitope profilesSuite of tools