Single cell profiling of tumour biopsies and heterogeneity in response of dedifferentiated melanoma.
Lim E, Lin Y, Pedersen B, Stewart A, Scolyer R, Long G, Yang J, Rizos H. Single cell profiling of tumour biopsies and heterogeneity in response of dedifferentiated melanoma. JCO Global Oncology 2023, 9: 64-64. DOI: 10.1200/go.2023.9.supplement_1.64.Peer-Reviewed Original ResearchResistance to MAPK inhibitionPro-inflammatory IL-6BRAF/MEK inhibitorsIL-6MAPK inhibitionTumor biopsiesAdvanced BRAF V600-mutant melanomaResponse to second-line treatmentTreated with immune checkpoint inhibitorsDT treatmentBRAF-mutant melanoma patientsResponse to MAPK inhibitionMelanoma cellsBRAF V600-mutant melanomaV600-mutant melanomaImmune checkpoint inhibitorsSecond-line treatmentTNFA signalingEx vivo treatmentElevated IL-6Increased IL-6Treated ex vivoDifferentiation stateImmune cell proportionsProportion of melanoma cells