Scalable workflow for characterization of cell-cell communication in COVID-19 patients
Lin Y, Loo L, Tran A, Lin D, Moreno C, Hesselson D, Neely G, Yang J. Scalable workflow for characterization of cell-cell communication in COVID-19 patients. PLOS Computational Biology 2022, 18: e1010495. PMID: 36197936, PMCID: PMC9534414, DOI: 10.1371/journal.pcbi.1010495.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsSevere patientsDisease severityDysfunctional immune responseDistinct disease outcomesHigher mortality riskSARS-CoV-2Different disease statesImmune cellsLung tissueDisease outcomeImmune responseMortality riskPatientsCell-cell interactionsPathogenic outcomesCritical symptomsCell-cell interaction patternsDisease statesSeverityOutcomesCellsLungSymptoms