Featured Publications
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled TrialsMicroneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis
Bailey AJM, Li HO, Tan MG, Cheng W, Dover JS. Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis. Journal Of The American Academy Of Dermatology 2021, 86: 797-810. PMID: 33857549, DOI: 10.1016/j.jaad.2021.03.116.Peer-Reviewed Original ResearchConceptsTreatment of melasmaTopical therapyMelasma severitySystematic reviewSerious adverse eventsTopical tranexamic acidEfficacy of microneedlingPlatelet-rich plasmaAdverse eventsTopical interventionsTopical medicationsTranexamic acidProspective studyEligible studiesRadiofrequency microneedlingPRISMA guidelinesTherapyMicroneedlingMelasmaStudy designVitamin CAdjuvantWeeksDepigmenting agentTreatmentAdverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study
Calder LA, Perry J, Yan JW, De Gorter R, Sivilotti MLA, Eagles D, Myslik F, Borgundvaag B, Émond M, McRae AD, Taljaard M, Thiruganasambandamoorthy V, Cheng W, Forster AJ, Stiell IG. Adverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study. Annals Of Emergency Medicine 2021, 77: 561-574. PMID: 33612283, DOI: 10.1016/j.annemergmed.2020.12.012.Peer-Reviewed Original ResearchConceptsAcute heart failureAdverse eventsEmergency department patientsED visitsDepartment patientsHeart failureAtrial fibrillationHealth care provider visitsRecent-onset atrial fibrillationClinical practice guideline adherenceIndex ED visitPractice guideline adherenceAdverse event incidenceProspective cohort studyAdverse event ratesCase summariesQuality improvement opportunitiesFactor themesAdverse event typesCanadian EDsSentinel diagnosesED dischargeProvider visitsAdult patientsCohort studyOptimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis
LeVasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy AA, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. Optimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis. PLOS ONE 2021, 16: e0245794. PMID: 33539414, PMCID: PMC7861370, DOI: 10.1371/journal.pone.0245794.Peer-Reviewed Original ResearchConceptsBody mass indexStandard careCancer patientsDietary interventionAnthropometric measuresLifestyle interventionWaist circumferenceWeight lossSystematic reviewCochrane Trial RegistryEffective lifestyle interventionsGreater BMI reductionMedian intervention durationOptimal lifestyle interventionCombination strategiesAdult cancer patientsWeight loss interventionEffects of exerciseEarly-stage cancerOutcomes of interestMore weight lossBMI reductionAdult patientsExercise interventionTrials RegistryPharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis
Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Hutton B. Pharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis. PLOS ONE 2020, 15: e0237523. PMID: 32870918, PMCID: PMC7462264, DOI: 10.1371/journal.pone.0237523.Peer-Reviewed Original ResearchConceptsComplete vertigo controlEndolymphatic sac decompressionRandomized clinical trialsEndolymphatic duct blockageIT steroidsVertigo controlMeniere's diseaseIT gentamicinSurgical interventionSystematic reviewKey patient outcomesHigh cumulative dosageBest treatment optionSensorineural hearing lossEDB groupESD groupAural fullnessIntratympanic gentamicinSteroid injectionVertigo attacksHead trialsHearing preservationSurgical therapyCochrane LibraryCumulative dosageCitation impact was highly variable for reporting guidelines of health research: a citation analysis
Caulley L, Cheng W, Catalá-López F, Whelan J, Khoury M, Ferraro J, Husereau D, Altman DG, Moher D. Citation impact was highly variable for reporting guidelines of health research: a citation analysis. Journal Of Clinical Epidemiology 2020, 127: 96-104. PMID: 32712175, DOI: 10.1016/j.jclinepi.2020.07.013.Peer-Reviewed Original ResearchCombination Tests in the Diagnosis of Chronic Periprosthetic Joint Infection: Systematic Review and Development of a Stepwise Clinical Decision-Making Tool.
Abdelbary H, Cheng W, Ahmadzai N, Carli AV, Shea BJ, Hutton B, Fergusson DA, Beaulé PE. Combination Tests in the Diagnosis of Chronic Periprosthetic Joint Infection: Systematic Review and Development of a Stepwise Clinical Decision-Making Tool. Journal Of Bone And Joint Surgery 2020, 102: 114-124. PMID: 32870618, DOI: 10.2106/jbjs.20.00097.Peer-Reviewed Original ResearchComparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses.
Hutton B, Hersi M, Cheng W, Pratt M, Barbeau P, Mazzarello S, Ahmadzai N, Skidmore B, Morgan SC, Bordeleau L, Ginex PK, Sadeghirad B, Morgan RL, Cole KM, Clemons M. Comparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses. Oncology Nursing Forum 2020, 47: e86-e106. PMID: 32555553, PMCID: PMC7891229, DOI: 10.1188/20.onf.e86-e106.Peer-Reviewed Original ResearchConceptsHot flash frequencyHot flashesProstate cancerHot flash scoreHistory of breastHot flash severityQuality of lifeFlash frequencyActive therapyPatients' qualitySystematic reviewAbstractTextMeta-AnalysisNarrative synthesisMore interventionsDATA EVALUATIONLiterature searchPatientsTherapyCancerBreastLittle dataInterventionMinimal dataTreatmentDoes N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope?
Thiruganasambandamoorthy V, McRae AD, Rowe BH, Sivilotti MLA, Mukarram M, Nemnom MJ, Booth RA, Calder LA, Stiell IG, Wells GA, Cheng W, Taljaard M. Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope? Annals Of Internal Medicine 2020, 172: 648-655. PMID: 32340039, DOI: 10.7326/m19-3515.Peer-Reviewed Original ResearchConceptsCanadian Syncope Risk ScoreSerious adverse eventsPro-B-type natriuretic peptideSerum NT-proBNP concentrationNT-proBNP concentrationsNT-proBNPNatriuretic peptideED patientsN-terminal pro-B-type natriuretic peptideTerminal pro-B-type natriuretic peptidePhysicians Services Incorporated FoundationIndex ED visitNT-proBNP valuesAdult ED patientsProspective cohort studySerum NT-proBNPEmergency department patientsNet reclassification indexHeterogeneity of outcomesAdjudication of outcomesNoncardiac eventsED dispositionAdverse eventsCohort studyComposite outcomeDiagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Klompas M, Kyeremanteng K, Mehta S, English SW, Muscedere J, Cook DJ, Torres A, Ranzani OT, Fox-Robichaud AE, Alhazzani W, Munshi L, Guyatt GH, Rochwerg B. Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Medicine 2020, 46: 1170-1179. PMID: 32306086, PMCID: PMC7223448, DOI: 10.1007/s00134-020-06036-z.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaEndotracheal aspiratesChest radiographyDiagnosis of VAPBronchoscopic sampling methodsIll adult patientsPhysical examination findingsEnglish-language studiesUnnecessary antimicrobial useAdult patientsVAP diagnosisPurulent secretionsExamination findingsPhysical examinationClinical indicatorsAntibiotic treatmentHistopathological analysisStudy qualitySystematic reviewAntimicrobial usePooled sensitivityDiagnosisPneumoniaReference standardRadiographyCohort Study of Features Used by Experts to Diagnose Transient Ischemic Attack
Fitzpatrick T, Gocan S, Wang CQ, Bourgoin A, Taljaard M, Cheng W, Dowlatshahi D, Stotts G, Shamy M. Cohort Study of Features Used by Experts to Diagnose Transient Ischemic Attack. The Neurohospitalist 2020, 10: 245-249. PMID: 32983341, PMCID: PMC7495706, DOI: 10.1177/1941874420908485.Peer-Reviewed Original ResearchTransient ischemic attackTIA/strokeStroke prevention clinicFinal diagnosisIschemic attackSecondary stroke prevention therapyStroke prevention servicesStroke prevention therapyMonocular vision lossRetrospective chart reviewLogistic regression analysisMultinomial logistic regression analysisBackward eliminationPrevention clinicStroke neurologistsChart reviewCohort studyNeurological eventsPrevention therapyUnilateral weaknessHomonymous hemianopiaReferral characteristicsVision lossSudden onsetInclusion criteriaAccuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients with febrile neutropenia: A systematic review and meta-analysis
Zheng B, Toarta C, Cheng W, Taljaard M, Reaume N, Perry JJ. Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients with febrile neutropenia: A systematic review and meta-analysis. Critical Reviews In Oncology/Hematology 2020, 149: 102922. PMID: 32244162, DOI: 10.1016/j.critrevonc.2020.102922.Peer-Reviewed Original ResearchConceptsMultinational AssociationSupportive careSerious complicationsClinical indicesPooled sensitivitySystematic reviewFebrile neutropenia patientsCISNE scoreMASCC scoreFebrile neutropeniaAcute settingAdult patientsCochrane DatabaseNeutropenia patientsPatientsComplicationsScoresCancerCareAssociationSpecificityNeutropeniaMASCCEMBASEReviewImpact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation
Bhatt M, Cheng W, Roback MG, Johnson DW, Taljaard M, Canada T. Impact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation. Academic Emergency Medicine 2020, 27: 217-227. PMID: 31894606, DOI: 10.1111/acem.13913.Peer-Reviewed Original ResearchConceptsPositive pressure ventilationOxygen desaturationOpioid administrationAdverse eventsSedation-related adverse eventsCanadian pediatric EDsPrimary risk factorImpact of timingOpioid typeSedation medicationsRespiratory depressionProspective cohortPediatric EDPressure ventilationSedative agentsOriginal cohortProcedural sedationRisk factorsPainful proceduresProcedure typeSedation outcomesMultivariable regressionOpioidsHigh incidenceSedationPre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Vaillancourt C, Rowan KM, Harrison DA, Nolan JP, Kyeremanteng K, McIsaac DI, Guyatt GH, Perry JJ. Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis. The BMJ 2019, 367: l6373. PMID: 31801749, PMCID: PMC6891802, DOI: 10.1136/bmj.l6373.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestPrognostic factorsSystematic reviewReduced oddsPrimary analysisInitial shockable rhythmIntra-arrest factorsPre-arrest factorsHigh-certainty evidenceChronic kidney diseaseDuration of resuscitationRisk of biasEnglish-language studiesWeb of ScienceActive malignancyCertainty evidenceCohort studyGRADE approachOdds of survivalCochrane DatabaseMale sexKidney diseaseShockable rhythmRelevant confoundersAre all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia
Augustine S, Cheng W, Avey MT, Chan ML, Lingappa SMC, Hutton B, Thébaud B. Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia. Stem Cells Translational Medicine 2019, 9: 158-168. PMID: 31746123, PMCID: PMC6988768, DOI: 10.1002/sctm.19-0193.Peer-Reviewed Original ResearchConceptsMesenchymal stromal cellsCell-based therapiesBronchopulmonary dysplasiaStem cell-based therapiesSystematic reviewDifferent cell-based therapiesExperimental neonatal lung injuryAvailable preclinical dataNeonatal lung injuryPreterm birth complicationsClinical translationPreclinical experimental designLung injuryUnclear riskBirth complicationsPreclinical dataEffective therapyPreclinical studiesRodent modelsSuccessful clinical translationHead comparisonTherapyStromal cellsSelect outcomesCell productsNumber needed to treat in indirect treatment comparison
Guyot P, Cheng W, Tremblay G, Copher R, Burnett H, Li X, Makin C. Number needed to treat in indirect treatment comparison. Journal Of Comparative Effectiveness Research 2018, 7: 259-269. PMID: 29537878, DOI: 10.2217/cer-2017-0023.Peer-Reviewed Original ResearchConceptsRR-DTC patientsIndirect treatment comparisonIndirect comparisonRadioiodine-refractory differentiated thyroid cancer patientsDifferentiated thyroid cancer patientsTreatment comparisonsThyroid cancer patientsCancer patientsDichotomous outcomesLenvatinibPatientsSorafenibTreatment effectsNNTSummary measuresPrognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta‐analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Thiruganasambandamoorthy V, Kyeremanteng K, Perry JJ. Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta‐analysis. Academic Emergency Medicine 2018, 26: 140-151. PMID: 30375097, DOI: 10.1111/acem.13649.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsPrediction of MACEAdverse cardiac eventsHEART scorePrediction of mortalityChest painMyocardial infarctionPrognostic accuracyCardiac eventsTIMI scoreLow-risk thresholdSystematic reviewPrediction of MIMyocardial Infarction (TIMI) scoreAdult ED patientsChest pain patientsShort-term incidenceClinical decision instrumentWeb of ScienceAdult patientsPain patientsED patientsRisk stratificationCochrane DatabasePatient populationNecrotizing Soft Tissue Infection
Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ. Necrotizing Soft Tissue Infection. Annals Of Surgery 2019, 269: 58-65. PMID: 29672405, DOI: 10.1097/sla.0000000000002774.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsTissue infectionsComputed tomographyPlain radiographyEarly surgical consultationPhysical examination signsLife-threatening diagnosisLaboratory Risk IndicatorNecrotizing Fasciitis (LRINEC) scorePhysical examination featuresPoor sensitivityEnglish-language studiesHierarchical summary receiverExamination signsFasciitis (LRINEC) scoreLRINEC scoreSurgical managementPhysical examinationSurgical consultationDefinitive diagnosisExamination featuresBACKGROUND DATANSTIExternal validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh
Murphy MS, Hawken S, Cheng W, Wilson LA, Lamoureux M, Henderson M, Pervin J, Chowdhury A, Gravett C, Lackritz E, Potter BK, Walker M, Little J, Rahman A, Chakraborty P, Wilson K. External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh. ELife 2019, 8: e42627. PMID: 30887951, PMCID: PMC6424558, DOI: 10.7554/elife.42627.Peer-Reviewed Original ResearchConceptsGestational ageGestational age estimationCord bloodNewborn metabolic profilesHeel prick samplesLow-resource settingsTerm infantsPreterm birthHeel prickPopulation-level estimatesPostnatal gestational age estimationBlood spotsMetabolic profileExternal validationInfantsScreening facilityAgeBloodFeasible optionMajority of samplesNewbornsPrickCordWeeksFISH Panel for Leukemic Cutaneous T-Cell Lymphoma: Extended Patient Cohort Correlation with Blood Involvement and Clinical Outcomes
Avery J, Kim R, Cheng W, Foss F, Girardi M. FISH Panel for Leukemic Cutaneous T-Cell Lymphoma: Extended Patient Cohort Correlation with Blood Involvement and Clinical Outcomes. JID Innovations 2023, 3: 100212. PMID: 37674691, PMCID: PMC10477749, DOI: 10.1016/j.xjidi.2023.100212.Peer-Reviewed Original ResearchSignal transducerGene copy number variationActivator of transcriptionCopy number variationsGene copy number alterationsGenomic basisCopy number alterationsRelevant genesGenomic sequencingNumber variationsFISH panelNumber alterationsDe novoCost-effective panelFISH resultsAbnormal FISH resultsActivatorGene panelTranscriptionLeukemic cutaneous T-cell lymphomaCutaneous T-cell lymphomaGenesSequencingT-cell lymphomaDeletion