Featured Publications
Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Klompas M, Kyeremanteng K, Mehta S, English SW, Muscedere J, Cook DJ, Torres A, Ranzani OT, Fox-Robichaud AE, Alhazzani W, Munshi L, Guyatt GH, Rochwerg B. Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Medicine 2020, 46: 1170-1179. PMID: 32306086, PMCID: PMC7223448, DOI: 10.1007/s00134-020-06036-z.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaEndotracheal aspiratesChest radiographyDiagnosis of VAPBronchoscopic sampling methodsIll adult patientsPhysical examination findingsEnglish-language studiesUnnecessary antimicrobial useAdult patientsVAP diagnosisPurulent secretionsExamination findingsPhysical examinationClinical indicatorsAntibiotic treatmentHistopathological analysisStudy qualitySystematic reviewAntimicrobial usePooled sensitivityDiagnosisPneumoniaReference standardRadiographyNecrotizing Soft Tissue Infection
Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ. Necrotizing Soft Tissue Infection. Annals Of Surgery 2019, 269: 58-65. PMID: 29672405, DOI: 10.1097/sla.0000000000002774.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsTissue infectionsComputed tomographyPlain radiographyEarly surgical consultationPhysical examination signsLife-threatening diagnosisLaboratory Risk IndicatorNecrotizing Fasciitis (LRINEC) scorePhysical examination featuresPoor sensitivityEnglish-language studiesHierarchical summary receiverExamination signsFasciitis (LRINEC) scoreLRINEC scoreSurgical managementPhysical examinationSurgical consultationDefinitive diagnosisExamination featuresBACKGROUND DATANSTI
2022
Accuracy of presenting symptoms, physical examination, and imaging for diagnosis of ruptured abdominal aortic aneurysm: Systematic review and meta‐analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Strauss SA, Mutter E, McIsaac DI, Kyeremanteng K, Kubelik D, Jetty P, Nagpal SK, Thiruganasambandamoorthy V, Roberts DJ, Perry JJ. Accuracy of presenting symptoms, physical examination, and imaging for diagnosis of ruptured abdominal aortic aneurysm: Systematic review and meta‐analysis. Academic Emergency Medicine 2022, 29: 486-496. PMID: 35220634, DOI: 10.1111/acem.14475.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmAortic aneurysmRuptured abdominal aortic aneurysmPooled sensitivityCases of rAAADiagnosis of AAAPhysical examination signsEarly surgical interventionLife-threatening conditionClassic clinical symptomsReference standardExamination signsAbdominal painAbdominal massVascular centersBack painClinical symptomsSurgical interventionPhysical examinationIntraoperative diagnosisUrgent transferCare ultrasoundRAAACTA diagnosisSystematic review
2019
Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ. Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis. The BMJ 2019, 366: l4225. PMID: 31340932, PMCID: PMC6651068, DOI: 10.1136/bmj.l4225.Peer-Reviewed Original ResearchConceptsElevated intracranial pressureOptic nerve sheath diameterIntracranial pressureNon-invasive testsMidline shiftIll patientsPhysical examinationSystematic reviewPhysical examination signsDoppler pulsatility indexGlasgow Coma ScaleNerve sheath diameterInvasive ICP monitoringPhysical examination featuresPatient-level dataDiagnostic Accuracy Studies toolTranscranial Doppler pulsatility indexEnglish-language studiesHierarchical summary receiverExamination signsComa ScaleCT findingsIll adultsPulsatility indexBasal cisterns