Featured Publications
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled Trials
2020
Pharmacological prevention of fractures in patients undergoing glucocorticoid therapies: a systematic review and network meta-analysis
Deng J, Silver Z, Huang E, Zheng E, Kavanagh K, Wen A, Cheng W, Dobransky J, Sanger S, Grammatopoulos G. Pharmacological prevention of fractures in patients undergoing glucocorticoid therapies: a systematic review and network meta-analysis. Rheumatology 2020, 60: 649-657. PMID: 32572480, DOI: 10.1093/rheumatology/keaa228.Peer-Reviewed Original ResearchConceptsNon-vertebral fracturesDecreased oddsAdult patientsSystematic reviewNon-vertebral fracture incidenceAnti-fracture efficacyCochrane Central RegisterSystematic review registrationVitamin D metabolitesAllied Health LiteratureInternational Prospective RegisterWeb of ScienceGlucocorticoid therapyEligible patientsCentral RegisterControlled TrialsPharmacological preventionVertebral fracturesFracture incidenceReview registrationGC therapyVitamin D.D metabolitesProspective RegisterI2 statistic
2018
The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis
Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, Lavallée LT, Fergusson DA, Breau RH. The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis. Transfusion Medicine Reviews 2018, 32: 165-178. PMID: 29567052, DOI: 10.1016/j.tmrv.2018.02.003.Peer-Reviewed Original ResearchTopical tranexamic acidTranexamic acidBlood lossIntravenous administrationTransfusion requirementsTopical applicationIntravenous tranexamic acidNon-surgical trialsVenous thromboembolic complicationsMean blood lossCochrane Central RegisterFull-text selectionMajority of trialsEffective hemostatic agentIntravenous groupThromboembolic riskVenous thromboembolismAdult patientsCentral RegisterThromboembolic complicationsBlood transfusionControlled TrialsTransfusion riskSafety profileSystemic absorption