Featured Publications
Pharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis
Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Hutton B. Pharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis. PLOS ONE 2020, 15: e0237523. PMID: 32870918, PMCID: PMC7462264, DOI: 10.1371/journal.pone.0237523.Peer-Reviewed Original ResearchConceptsComplete vertigo controlEndolymphatic sac decompressionRandomized clinical trialsEndolymphatic duct blockageIT steroidsVertigo controlMeniere's diseaseIT gentamicinSurgical interventionSystematic reviewKey patient outcomesHigh cumulative dosageBest treatment optionSensorineural hearing lossEDB groupESD groupAural fullnessIntratympanic gentamicinSteroid injectionVertigo attacksHead trialsHearing preservationSurgical therapyCochrane LibraryCumulative dosage
2021
Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
Thabet P, Joshi A, MacDonald E, Hutton B, Cheng W, Stevens A, Kanji S. Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews. PLOS ONE 2021, 16: e0244966. PMID: 33481817, PMCID: PMC7822342, DOI: 10.1371/journal.pone.0244966.Peer-Reviewed Original ResearchConceptsBeta-lactam antimicrobialsClinical cureSystematic reviewProlonged infusionBeta-lactam infusionDefinitive systematic reviewLess sick patientsLength of stayCurrent systematic reviewOverview of reviewsEmergence of resistanceBeta-lactam antibioticsSubsequent systematic reviewsAdverse eventsMicrobiological cureHospitalized patientsIll patientsClinical outcomesIntermittent infusionTreatment failureDATA EXTRACTIONCochrane LibraryMethodologic qualityPROSPERO registryBias assessment
2019
Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis
Ahmadzai N, Cheng W, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Esmaeilisaraji L, Kilty S, Hutton B. Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis. Systematic Reviews 2019, 8: 341. PMID: 31888735, PMCID: PMC6937806, DOI: 10.1186/s13643-019-1195-1.Peer-Reviewed Original ResearchConceptsSensorineural hearing lossMeniere's diseaseQuality of lifeSystematic reviewHearing-related disabilitySeverity of vertigoAttacks of vertigoIntractable Meniere's diseaseKey clinical trialsIntensity of tinnitusPre-specified eligibility criteriaCause of disabilityClinical treatment strategiesPlanned systematic reviewElectronic search strategyOptimal clinical treatment strategiesMedical information specialistBackgroundHearing lossVertigo attacksCochrane riskSurgical therapyBias toolSurgical interventionCochrane LibraryFuture trialsDiagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review.
Carli AV, Abdelbary H, Ahmadzai N, Cheng W, Shea B, Hutton B, Sniderman J, Philip Sanders BS, Esmaeilisaraji L, Skidmore B, Gauthier-Kwan OY, Bunting AC, Gauthier P, Crnic A, Logishetty K, Moher D, Fergusson D, Beaulé PE. Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review. Journal Of Bone And Joint Surgery 2019, 101: 635-649. PMID: 30946198, DOI: 10.2106/jbjs.18.00632.Peer-Reviewed Original ResearchConceptsChronic periprosthetic joint infectionPeriprosthetic joint infectionHigh riskTissue-based testsJoint infectionKnee replacementSystematic reviewC-reactive protein levelsWhite blood cell countDiagnostic accuracyDiagnostic testsDiagnostic Accuracy Studies-2 toolShort-term mortalityBlood cell countPolymorphonuclear neutrophil percentageAlpha-defensin testLeukocyte esterase reagent stripsTotal joint replacementHierarchical summary receiverDiagnostic test resultsDevastating complicationPeer-reviewed journalsNeutrophil percentagePoor outcomeCochrane LibraryComparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioural therapy for the treatment and management of chronic pain: A systematic review and network meta-analysis
Khoo EL, Small R, Cheng W, Hatchard T, Glynn B, Rice DB, Skidmore B, Kenny S, Hutton B, Poulin PA. Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioural therapy for the treatment and management of chronic pain: A systematic review and network meta-analysis. BMJ Mental Health 2019, 22: 26. PMID: 30705039, PMCID: PMC10270397, DOI: 10.1136/ebmental-2018-300062.Peer-Reviewed Original ResearchConceptsMindfulness-based stress reductionCognitive behavioral therapyPain intensityChronic painPhysical functioningPrimary outcome measureSecondary outcomesCochrane LibrarySTUDY SELECTIONOvid MEDLINEOutcome measuresDepression symptomsSystematic reviewControl interventionsBehavioral therapyStress reductionCP managementHelpful interventionsPainEffects networkTherapyAdditional researchControl conditionInterventionReview