The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis
Knight GM, Colijn C, Shrestha S, Fofana M, Cobelens F, White RG, Dowdy DW, Cohen T. The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis. Clinical Infectious Diseases 2015, 61: s147-s154. PMID: 26409276, PMCID: PMC4583567, DOI: 10.1093/cid/civ579.Peer-Reviewed Original ResearchFitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study
Salvatore PP, Becerra MC, Wiesch P, Hinkley T, Kaur D, Sloutsky A, Cohen T. Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study. The Journal Of Infectious Diseases 2015, 213: 149-155. PMID: 26092854, PMCID: PMC4676541, DOI: 10.1093/infdis/jiv347.Peer-Reviewed Original ResearchConceptsDrug resistance mutationsCase-control studyKatG Ser315Thr mutationMDR strainsMultiple case householdsResistance mutationsDrug resistance-associated mutationsMycobacterium tuberculosisMultidrug-resistant Mycobacterium tuberculosisSecondary household casesSer315Thr mutationMDR M. tuberculosisMultidrug-resistant tuberculosisMDR Mycobacterium tuberculosisResistance-associated polymorphismsLong-term prevalenceResistance-associated mutationsVivo fitness costsCase-control designEpidemiologic studiesHousehold casesTuberculosisExperimental modelM. tuberculosisMutations