2015
The potential impact of coinfection on antimicrobial chemotherapy and drug resistance
Birger RB, Kouyos RD, Cohen T, Griffiths EC, Huijben S, Mina MJ, Volkova V, Grenfell B, Metcalf CJE. The potential impact of coinfection on antimicrobial chemotherapy and drug resistance. Trends In Microbiology 2015, 23: 537-544. PMID: 26028590, PMCID: PMC4835347, DOI: 10.1016/j.tim.2015.05.002.Peer-Reviewed Original ResearchOrigin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens
Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch M. Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens. Microbiology And Molecular Biology Reviews 2015, 79: 101-116. PMID: 25652543, PMCID: PMC4402963, DOI: 10.1128/mmbr.00039-14.Peer-Reviewed Original ResearchConceptsMDR infectionsPublic health threatMultiple drug resistanceHigh prevalenceMore effective interventionsDifferent underlying mechanismsMultidrug resistanceEffective interventionsHealth threatUnderlying mechanismInfectionBacterial pathogensMDRCommon mechanismDifferent pathogensProliferationPathogensPrevalenceHypothetical mechanism
2009
What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, Givon-Lavi N, Dagan R, Lipsitch M. What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae? Journal Of The Royal Society Interface 2009, 7: 905-919. PMID: 19940002, PMCID: PMC2871802, DOI: 10.1098/rsif.2009.0400.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsStreptococcus pneumoniaeInfectious diseasesDrug-susceptible strainsHigher reproduction numberCent prevalenceSubstantial prevalencePersistent coexistenceDrug resistanceMultiple infectionsAntimicrobial useResistant strainsBacterial spreadAntimicrobial resistancePrevalenceDiseasePneumoniaeOutcomesReproduction numberTreatmentHost interactionsPathogensCoinfection
2008
Too Little of a Good Thing
Cohen T, Lipsitch M. Too Little of a Good Thing. Epidemiology 2008, 19: 588-589. PMID: 18552592, PMCID: PMC2652751, DOI: 10.1097/ede.0b013e31817734ba.Peer-Reviewed Original Research
2003
The effect of drug resistance on the fitness of Mycobacterium tuberculosis
Cohen T, Sommers B, Murray M. The effect of drug resistance on the fitness of Mycobacterium tuberculosis. The Lancet Infectious Diseases 2003, 3: 13-21. PMID: 12505028, DOI: 10.1016/s1473-3099(03)00483-3.Peer-Reviewed Original Research