2022
Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis
Yang C, Sobkowiak B, Naidu V, Codreanu A, Ciobanu N, Gunasekera KS, Chitwood MH, Alexandru S, Bivol S, Russi M, Havumaki J, Cudahy P, Fosburgh H, Allender CJ, Centner H, Engelthaler DM, Menzies NA, Warren JL, Crudu V, Colijn C, Cohen T. Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis. PLOS Medicine 2022, 19: e1003933. PMID: 35192619, PMCID: PMC8903246, DOI: 10.1371/journal.pmed.1003933.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisDrug-resistant M. tuberculosisM. tuberculosis strainsPutative transmission clustersM. tuberculosisTransmission clustersMultidrug-resistant M. tuberculosis strainsTuberculosis strainsMultiple M. tuberculosis strainsCulture-positive TB casesLocal transmissionMDR-TB epidemicDrug-susceptible tuberculosisDrug resistance mutationsDrug resistance profilesUrgency of interventionTB casesDemographic dataNew casesTuberculosisInadequate treatmentNatural historyResistance mutationsBeijing lineageMycobacterium tuberculosis
2021
Protective impacts of household-based tuberculosis contact tracing are robust across endemic incidence levels and community contact patterns
Havumaki J, Cohen T, Zhai C, Miller JC, Guikema SD, Eisenberg MC, Zelner J. Protective impacts of household-based tuberculosis contact tracing are robust across endemic incidence levels and community contact patterns. PLOS Computational Biology 2021, 17: e1008713. PMID: 33556077, PMCID: PMC7895355, DOI: 10.1371/journal.pcbi.1008713.Peer-Reviewed Original ResearchConceptsTuberculosis burdenCommunity transmissionGlobal tuberculosis control targetsSustained community transmissionHigh-incidence settingsHigh disease burdenTuberculosis contact tracingLow tuberculosis burdenHousehold contactsHousehold transmissionDisease burdenVaried incidenceContact patternsIncidence levelsProtective impactEpidemiological settingsInfected individualsNew casesProtective benefitsContact tracingCommunity contactsSuch interventionsInterventionBurdenProactive case
2018
Where is tuberculosis transmission happening? Insights from the literature, new tools to study transmission and implications for the elimination of tuberculosis
Auld SC, Shah NS, Cohen T, Martinson NA, Gandhi NR. Where is tuberculosis transmission happening? Insights from the literature, new tools to study transmission and implications for the elimination of tuberculosis. Respirology 2018, 23: 807-817. PMID: 29869818, PMCID: PMC6281783, DOI: 10.1111/resp.13333.Peer-Reviewed Original ResearchTB control activitiesEvidence-based public health interventionsElimination of tuberculosisBurden of tuberculosisInfection control programCommunity-based transmissionPublic health interventionsCommunity-based settingsUnderstanding of transmissionMiddle-income countriesContact investigationTB incidenceTB transmissionTB epidemicTB strainsTuberculosis transmissionPatterns of transmissionHealth interventionsMeaningful improvementsNew casesMolecular epidemiologyTuberculosisControl activitiesOngoing transmissionVentilation studies
2012
Multidrug Resistance Among New Tuberculosis Cases
Hedt BL, van Leth F, Zignol M, Cobelens F, van Gemert W, Nhung NV, Lyepshina S, Egwaga S, Cohen T. Multidrug Resistance Among New Tuberculosis Cases. Epidemiology 2012, 23: 293-300. PMID: 22249242, PMCID: PMC3276714, DOI: 10.1097/ede.0b013e3182459455.Peer-Reviewed Original Research
2008
Challenges in Estimating the Total Burden of Drug-resistant Tuberculosis
Cohen T, Colijn C, Wright A, Zignol M, Pym A, Murray M. Challenges in Estimating the Total Burden of Drug-resistant Tuberculosis. American Journal Of Respiratory And Critical Care Medicine 2008, 177: 1302-1306. PMID: 18369201, PMCID: PMC2720088, DOI: 10.1164/rccm.200801-175pp.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisDrug resistance surveillanceHIV/TB coinfectionAnti-Tuberculosis Drug Resistance SurveillanceResistance surveillanceSentinel site surveillanceBurden of tuberculosisMultidrug-resistant diseaseMultidrug-resistant tuberculosisTB control programsTB coinfectionTB casesHigh burdenMethodologic obstaclesSurveillance studyNew casesTotal burdenTuberculosisLaboratory capacityBurdenSurveillanceControl programsDiagnostic technologiesRecent recognitionTrue extent